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Ahmed Mohamed Abdelhakim

Other affiliations: Assiut University
Bio: Ahmed Mohamed Abdelhakim is an academic researcher from Cairo University. The author has contributed to research in topics: Randomized controlled trial & Cochrane Library. The author has an hindex of 5, co-authored 26 publications receiving 80 citations. Previous affiliations of Ahmed Mohamed Abdelhakim include Assiut University.

Papers
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TL;DR: In this paper, the authors compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality.

94 citations

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TL;DR: Inhalation aromatherapy administration especially with lavender can significantly reduce anxiety, pain, and heart rate in patients performed cardiac surgery, however, it is not associated with significant differences in systolic and diastolic blood pressure.

25 citations

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TL;DR: Women who received antenatal perineal massage had significantly lower incidence of episiotomies and perineals tears and better wound healing and less perineAL pain were evident in the antenatal each group.
Abstract: Most vaginal births are associated with trauma to the perineum. The morbidity associated with perineal trauma can be significant, especially when it leads to third- and fourth-degree perineal tears. We hypothesized that antenatal perineal massage could decrease the incidence of perineal trauma, particularly severe perineal tears and other postpartum complications. We searched four different databases from inception until August 2019 for the available trials. We included randomized controlled trials (RCTs) which assessed the effect of antenatal perineal massage (intervention group) versus control group (no antenatal perineal massage) in perineal trauma patients. Data were extracted from eligible studies and meta-analyzed using RevMan software. Primary outcomes were the risk of episiotomies and perineal tears. Secondary outcomes were perineal pain, second stage of labor duration, wound healing, anal incontinence, and Apgar scores at 1 and 5 min. Eleven RCTs with 3467 patients were analyzed. Women who received antenatal perineal massage had significantly lower incidence of episiotomies (RR = 0.79, 95% CI [0.72, 0.87], p < 0.001) and perineal tears (RR = 0.79, 95% CI [0.67, 0.94], p = 0.007), particularly the risk of third- and fourth-degree perineal tears (p = 0.03). Better wound healing and less perineal pain were evident in the antenatal perineal massage group. Antenatal perineal massage reduced the second stage of labor duration (p = 0.005) and anal incontinence (p = 0.003) with significant improvement in Apgar scores at 1 and 5 min (p = 0.01 and p = 0.02). Antenatal perineal massage is associated with a lower risk of severe perineal trauma and postpartum complications.

20 citations

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TL;DR: Vaginal progesterone can be used an alternative method for luteal phase support instead of IMP in ART and is significantly associated with more satisfaction compared to IMP.
Abstract: We aimed to compare the efficacy of vaginal progesterone versus intramuscular progesterone (IMP) for luteal phase support in assisted reproductive techniques (ART). A comprehensive electronic searc...

20 citations

Journal ArticleDOI
TL;DR: Music therapy had no positive effect in reducing anxiety, pain and satisfaction levels during colposcopy, and was found to have no effect on anxiety levels when compared with the control group.
Abstract: Background Music therapy has been used greatly in various medical procedures to reduce associated anxiety and pain. Objective to evaluate the evidence from published randomized clinical trials (RCTs) about the effect of music intervention in reducing patient's anxiety during the colposcopy. Search strategy Electronic databases included PubMed, Cochrane Library, Scopus and Web of Science were searched using the relevant MeSH terms. Selection criteria All RCTs assessing the effect of music therapy versus no music in reducing anxiety during colposcopy were considered. Eighty-five studies were identified of which five studies deemed eligible for this review. Data extraction The extracted outcomes were; anxiety, pain during and after the procedure, and satisfaction levels. They were pooled as mean difference in a fixed-effects model, using Review Manager 5.3 software for windows. Main results We found no effect of music therapy in reducing the anxiety levels when compared with the control group (SMD= -0.11, 95% CI [-0.36, 0.14], p = 0.4). No difference between music and control groups regarding pain during and after the procedure respectively (SMD= -0.20, 95% CI [-0.58, -0.18], p = 0.31) and (SMD=-0.10, 95% CI [-0.30, -0.10], p = 0.33). Conclusions Music therapy had no positive effect in reducing anxiety, pain and satisfaction levels during colposcopy.

14 citations


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TL;DR: In this paper, the authors compared the delivery of elective cancer surgery during the COVID-19 pandemic in periods of lockdown versus light restriction, and found that light restrictions were associated with a 0·6% non-operation rate (26 of 4521), moderate lockdowns with a 5·5% rate (201 of 3646); adjusted hazard ratio [HR] 0·81, 95% CI 0·77-0·84.
Abstract: Background Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during the COVID-19 pandemic in periods of lockdown versus light restriction. Methods This international, prospective, cohort study enrolled 20 006 adult (≥18 years) patients from 466 hospitals in 61 countries with 15 cancer types, who had a decision for curative surgery during the COVID-19 pandemic and were followed up until the point of surgery or cessation of follow-up (Aug 31, 2020). Average national Oxford COVID-19 Stringency Index scores were calculated to define the government response to COVID-19 for each patient for the period they awaited surgery, and classified into light restrictions (index 60). The primary outcome was the non-operation rate (defined as the proportion of patients who did not undergo planned surgery). Cox proportional-hazards regression models were used to explore the associations between lockdowns and non-operation. Intervals from diagnosis to surgery were compared across COVID-19 government response index groups. This study was registered at ClinicalTrials.gov, NCT04384926. Findings Of eligible patients awaiting surgery, 2003 (10·0%) of 20 006 did not receive surgery after a median follow-up of 23 weeks (IQR 16-30), all of whom had a COVID-19-related reason given for non-operation. Light restrictions were associated with a 0·6% non-operation rate (26 of 4521), moderate lockdowns with a 5·5% rate (201 of 3646; adjusted hazard ratio [HR] 0·81, 95% CI 0·77-0·84; p Interpretation Cancer surgery systems worldwide were fragile to lockdowns, with one in seven patients who were in regions with full lockdowns not undergoing planned surgery and experiencing longer preoperative delays. Although short-term oncological outcomes were not compromised in those selected for surgery, delays and non-operations might lead to long-term reductions in survival. During current and future periods of societal restriction, the resilience of elective surgery systems requires strengthening, which might include protected elective surgical pathways and long-term investment in surge capacity for acute care during public health emergencies to protect elective staff and services. Funding National Institute for Health Research Global Health Research Unit, Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, Medtronic, Sarcoma UK, The Urology Foundation, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research.

146 citations

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TL;DR: A recent review as discussed by the authors presented an update on recent advances and breakthroughs in cancer therapies, including stem cell therapy, targeted therapy, ablation therapy, nanoparticles, natural antioxidants, radionics, chemodynamic therapy, sonodynamic therapy and ferroptosis-based therapy.
Abstract: Cancer is a global health problem responsible for one in six deaths worldwide. Treating cancer has been a highly complex process. Conventional treatment approaches, such as surgery, chemotherapy, and radiotherapy, have been in use, while significant advances are being made in recent times, including stem cell therapy, targeted therapy, ablation therapy, nanoparticles, natural antioxidants, radionics, chemodynamic therapy, sonodynamic therapy, and ferroptosis-based therapy. Current methods in oncology focus on the development of safe and efficient cancer nanomedicines. Stem cell therapy has brought promising efficacy in regenerating and repairing diseased or damaged tissues by targeting both primary and metastatic cancer foci, and nanoparticles brought new diagnostic and therapeutic options. Targeted therapy possessed breakthrough potential inhibiting the growth and spread of specific cancer cells, causing less damage to healthy cells. Ablation therapy has emerged as a minimally invasive procedure that burns or freezes cancers without the need for open surgery. Natural antioxidants demonstrated potential tracking down free radicals and neutralizing their harmful effects thereby treating or preventing cancer. Several new technologies are currently under research in clinical trials, and some of them have already been approved. This review presented an update on recent advances and breakthroughs in cancer therapies.

122 citations

Journal ArticleDOI
Pingping Guo1, Ping Li1, Xuehui Zhang1, Na Liu1, Jie Wang1, Shu Yang1, Lin Yu1, Wei Zhang1 
TL;DR: Aromatherapy is an effective intervention for reducing preoperative anxiety in adults and short-length aromatherapy inhalation seems to be more worthy of being recommended in clinical settings.

40 citations

Journal ArticleDOI
F. Jasmijn Smits, A.C. Henry, Marc G. Besselink, Olivier R. Busch, Casper H.J. van Eijck, Mark J. Arntz, Thomas L. Bollen, Otto M. van Delden, Daniel A. F. van den Heuvel, Christiaan van der Leij, Krijn P. van Lienden, Adriaan Moelker, Bert A. Bonsing, Inne H.M. Borel Rinkes, Koop Bosscha, Ronald M. van Dam, Wouter J. M. Derksen, Marcel den Dulk, Sebastiaan Festen, Bas Groot Koerkamp, Robbert J. de Haas, Jeroen Hagendoorn, E. Van der Harst, Ignace H. J. T. de Hingh, Geert Kazemier, M. M. Van Der Kolk, M. S. L. Liem, Daniel J. Lips, Misha D. P. Luyer, Vincent E de Meijer, J. Sven D. Mieog, Vincent B. Nieuwenhuijs, Gijs A. Patijn, Wouter W. te Riele, Daphne Roos, Jennifer M.J. Schreinemakers, Martijn W J Stommel, F. Wit, B.M. Zonderhuis, Lois A. Daamen, Cornelis H. van Werkhoven, I. Quintus Molenaar, Hjalmar C. van Santvoort, J. G. A. M. Blomjous, MT de Boer, Peter B. van den Boezem, Stefan A.W. Bouwense, Rutger C G Bruijnen, Ciairín de Buis, Marco Del Chiaro, P. P. L. O. Coene, Marielle M.E. Coolsen, Freek Daams, Kees Dejong, Werner A. Draaisma, HH Eker, AH Elsen, M. Gerhards, Hermien Hartog, FJ Hoogwater, Fadilah Nur Imani, Sjoerd F. M. Jenniskens, K. de Jong, TM Karsten, Jm Klaase, Rhj de Kleine, Cjhm van Laarhoven, H. V. D. Lelij, Eric R. Manusama, Mark Meerdink, Martijn R. Meijerink, Joost Nederend, MW Nijkamp, CL Nota, Rj. Porte, John Reef, Philip R. de Reuver, C. S. P. Van Rijswijk, T. Romkens, Coen G. Rupert, G. van der Schelling, JP Serafino, LD Vos, M. R. Vriens, E. Beers-Vural, JM Wagtenberg, J. Wijsman, RF de Wilde, Clemens Wolfgang, HJ Zeh 
TL;DR: The algorithm for the early recognition and minimally invasive management of complications after pancreatic resection considerably improved clinical outcomes compared with usual care.

36 citations

Journal ArticleDOI
TL;DR: In this article , an open-label, nationwide, stepped-wedge cluster-randomised trial that included all patients having pancreatic resection during a 22-month period in the Netherlands was conducted.

34 citations