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Author

Ai-Bao Xia

Other affiliations: Zhejiang University
Bio: Ai-Bao Xia is an academic researcher from Zhejiang University of Technology. The author has contributed to research in topics: Enantioselective synthesis & Michael reaction. The author has an hindex of 14, co-authored 65 publications receiving 838 citations. Previous affiliations of Ai-Bao Xia include Zhejiang University.


Papers
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Journal ArticleDOI
TL;DR: The first highly enantioselective organocatalytic Michael addition of 4-hydroxycoumarins was reported in this paper, where the authors used 4-Houmarin as an enantioregressive additive.
Abstract: The first highly enantioselective organocatalytic Michael addition of 4-hydroxycoumarins is reported.

126 citations

Journal ArticleDOI
TL;DR: Deep-sea Diels-Alder reaction of cyclohexenones with aromatic nitrooleolefins can be carried out in seawater and brine by an in situ enamine activation involving a one-step concerted addition pathway.
Abstract: Tiefsee-Diels-Alder-Reaktion: Die asymmetrische organokatalytische Diels-Alder-Reaktion zwischen Cyclohexenonen und aromatischen Nitroolefinen gelingt in Meerwasser und gesattigter Kochsalzlosung. Die Reaktion verlauft als saurekatalysierte Enaminaktivierung uber eine einstufige konzertierte Addition (siehe Schema).

105 citations

Journal ArticleDOI
TL;DR: A novel Pd(OAc)2-NFSI-TFA system was developed for the highly selective ortho-monofluorination directed by diverse aryl-N-heterocyclic directing groups e.g., quinoxaline, pyrazole, benzo[d]oxazole, and pyrazine derivatives.

87 citations

Journal ArticleDOI
TL;DR: A novel and effective organocatalytic system consisting of pyrrolidinyl-thioimidazole and a chiral thioureido acid efficiently catalyzed the asymmetric Michael addition reactions of ketones to nitroolefins to afford the adducts with high diastereoselectivity and excellent enantioselectivities.
Abstract: A novel and effective organocatalytic system consisting of pyrrolidinyl-thioimidazole and a chiral thioureido acid efficiently catalyzed the asymmetric Michael addition reactions of ketones to nitroolefins to afford the adducts with high diastereoselectivities (up to 99 : 1) and excellent enantioselectivities (up to 99% ee).

63 citations


Cited by
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Journal ArticleDOI
10 Mar 1970

8,159 citations

01 Dec 2007

1,121 citations

Journal ArticleDOI
TL;DR: This perspective aims to highlight the benefits of synergistic catalysis using many of the successful examples of synergism catalysis found in the literature.
Abstract: Synergistic catalysis is a synthetic strategy wherein both the nucleophile and the electrophile are simultaneously activated by two separate and distinct catalysts to afford a single chemical transformation. This powerful catalysis strategy leads to several benefits, specifically synergistic catalysis can (i) introduce new, previously unattainable chemical transformations, (ii) improve the efficiency of existing transformations, and (iii) create or improve catalytic enantioselectivity where stereocontrol was previously absent or challenging. This perspective aims to highlight these benefits using many of the successful examples of synergistic catalysis found in the literature.

896 citations

Journal ArticleDOI
23 May 2016
TL;DR: A review of general purpose solvent selection guides can be found in this paper, highlighting their similarities and differences and how they can be used to enhance the greenness of chemical processes, particularly in laboratory organic synthesis and the pharmaceutical industry.
Abstract: Driven by legislation and evolving attitudes towards environmental issues, establishing green solvents for extractions, separations, formulations and reaction chemistry has become an increasingly important area of research Several general purpose solvent selection guides have now been published with the aim to reduce use of the most hazardous solvents This review serves the purpose of explaining the role of these guides, highlighting their similarities and differences How they can be used most effectively to enhance the greenness of chemical processes, particularly in laboratory organic synthesis and the pharmaceutical industry, is addressed in detail

756 citations