A
Ailsa Hart
Researcher at Imperial College London
Publications - 348
Citations - 20417
Ailsa Hart is an academic researcher from Imperial College London. The author has contributed to research in topics: Inflammatory bowel disease & Medicine. The author has an hindex of 56, co-authored 279 publications receiving 15796 citations. Previous affiliations of Ailsa Hart include London North West Healthcare NHS Trust & The Chinese University of Hong Kong.
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Journal ArticleDOI
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Luke Jostins,Stephan Ripke,Rinse K. Weersma,Richard H. Duerr,Dermot P.B. McGovern,Ken Y. Hui,James Lee,L. Philip Schumm,Yashoda Sharma,Carl A. Anderson,Jonah Essers,Mitja Mitrovic,Kaida Ning,Isabelle Cleynen,Emilie Theatre,Sarah L. Spain,Soumya Raychaudhuri,Philippe Goyette,Zhi Wei,Clara Abraham,Jean-Paul Achkar,Tariq Ahmad,Leila Amininejad,Ashwin N. Ananthakrishnan,Vibeke Andersen,Jane M. Andrews,Leonard Baidoo,Tobias Balschun,Peter A. Bampton,Alain Bitton,Gabrielle Boucher,Stephan Brand,Carsten Büning,Ariella Cohain,Sven Cichon,Mauro D'Amato,Dirk De Jong,Kathy L Devaney,Marla Dubinsky,Cathryn Edwards,David Ellinghaus,Lynnette R. Ferguson,Denis Franchimont,Karin Fransen,Richard B. Gearry,Michel Georges,Christian Gieger,Jürgen Glas,Talin Haritunians,Ailsa Hart,Christopher J. Hawkey,Matija Hedl,Xinli Hu,Tom H. Karlsen,Limas Kupčinskas,Subra Kugathasan,Anna Latiano,Debby Laukens,Ian C. Lawrance,Charlie W. Lees,Edouard Louis,Gillian Mahy,John C. Mansfield,Angharad R. Morgan,Craig Mowat,William G. Newman,Orazio Palmieri,Cyriel Y. Ponsioen,Uroš Potočnik,Natalie J. Prescott,Miguel Regueiro,Jerome I. Rotter,Richard K Russell,Jeremy D. Sanderson,Miquel Sans,Jack Satsangi,Stefan Schreiber,Lisa A. Simms,Jurgita Sventoraityte,Stephan R. Targan,Kent D. Taylor,Mark Tremelling,Hein W. Verspaget,Martine De Vos,Cisca Wijmenga,David C. Wilson,Juliane Winkelmann,Ramnik J. Xavier,Sebastian Zeissig,Bin Zhang,Clarence K. Zhang,Hongyu Zhao,Mark S. Silverberg,Vito Annese,Hakon Hakonarson,Steven R. Brant,Graham L. Radford-Smith,Christopher G. Mathew,John D. Rioux,Eric E. Schadt,Mark J. Daly,Andre Franke,Miles Parkes,Severine Vermeire,Jeffrey C. Barrett,Judy H. Cho +105 more
TL;DR: A meta-analysis of Crohn’s disease and ulcerative colitis genome-wide association scans is undertaken, followed by extensive validation of significant findings, with a combined total of more than 75,000 cases and controls.
Journal ArticleDOI
The gut microbiota and host health: a new clinical frontier
Julian R. Marchesi,David H. Adams,Francesca Fava,Gerben D. A. Hermes,Gideon M. Hirschfield,Georgina L. Hold,Mohammed Nabil Quraishi,James Kinross,Hauke Smidt,Kieran Tuohy,Linda V. Thomas,Erwin G. Zoetendal,Ailsa Hart +12 more
TL;DR: The potential of manipulating the gut microbiota in these disorders is assessed, with an examination of the latest and most relevant evidence relating to antibiotics, probiotics, prebiotics, polyphenols and faecal microbiota transplantation.
Journal ArticleDOI
Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders.
Fernando Magro,Paolo Gionchetti,Rami Eliakim,Sandro Ardizzone,Alessandro Armuzzi,Manuel Barreiro-de Acosta,Johan Burisch,Krisztina Gecse,Ailsa Hart,Pieter Hindryckx,Cord Langner,Jimmy K. Limdi,Gianluca Pellino,Edyta Zagórowicz,Tim Raine,Marcus Harbord,Florian Rieder +16 more
TL;DR: This research presents a meta-analyses of Gastroenterology and Hepatology at the cellular and molecular level, which shows clear trends in the development of immune-oncology-metabolical pathways towards “clinically checkpoints”.
Journal ArticleDOI
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease
Katrina M. de Lange,Loukas Moutsianas,James Lee,Christopher A. Lamb,Yang Luo,Yang Luo,Yang Luo,Nicholas A. Kennedy,Luke Jostins,Luke Jostins,Daniel L. Rice,Javier Gutierrez-Achury,Sun-Gou Ji,Graham A. Heap,Elaine R. Nimmo,Cathryn Edwards,Paul Henderson,Paul Henderson,Craig Mowat,Jeremy D. Sanderson,Jack Satsangi,Alison Simmons,Alison Simmons,David C. Wilson,David C. Wilson,Mark Tremelling,Ailsa Hart,Christopher G. Mathew,Christopher G. Mathew,William G. Newman,William G. Newman,Miles Parkes,Charlie W. Lees,Holm H. Uhlig,Christopher J. Hawkey,Natalie J. Prescott,Tariq Ahmad,John C. Mansfield,Carl A. Anderson,Jeffrey C. Barrett +39 more
TL;DR: This work identified 25 new susceptibility loci, 3 of which contain integrin genes that encode proteins in pathways that have been identified as important therapeutic targets in inflammatory bowel disease and identified 3 associated variants that are correlated with expression changes in response to immune stimulus at two of these genes.
Journal ArticleDOI
European consensus conference on faecal microbiota transplantation in clinical practice
Giovanni Cammarota,Gianluca Ianiro,Herbert Tilg,Mirjana Rajilić-Stojanović,Patrizia Kump,Reetta Satokari,Harry Sokol,Perttu Arkkila,Cristina Pintus,Ailsa Hart,Jonathan Segal,Marina Aloi,Luca Masucci,Antonio Molinaro,Franco Scaldaferri,Giovanni Gasbarrini,Antonio López-Sanromán,Alexander Link,Pieter F. de Groot,Willem M. de Vos,Willem M. de Vos,Christoph Högenauer,Peter Malfertheiner,Eero Mattila,Tomica Milosavljevic,Max Nieuwdorp,Max Nieuwdorp,Maurizio Sanguinetti,Magnus Simren,Antonio Gasbarrini +29 more
TL;DR: This consensus report strongly recommends the implementation of FMT centres for the treatment of C. difficile infection as well as traces the guidelines of technicality, regulatory, administrative and laboratory requirements.