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Aimy Sebastian
Researcher at Lawrence Livermore National Laboratory
Publications - 48
Citations - 3885
Aimy Sebastian is an academic researcher from Lawrence Livermore National Laboratory. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 13, co-authored 31 publications receiving 3249 citations. Previous affiliations of Aimy Sebastian include University of California, Merced & University of California, Berkeley.
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Journal ArticleDOI
Human Protein Reference Database—2009 update
T. S. Keshava Prasad,Renu Goel,Kumaran Kandasamy,Kumaran Kandasamy,Shivakumar Keerthikumar,Sameer Kumar,Suresh Mathivanan,Deepthi Telikicherla,Rajesh Raju,Beema Shafreen,Abhilash K. Venugopal,Lavanya Balakrishnan,Arivusudar Marimuthu,Sutopa Banerjee,Devi S. Somanathan,Aimy Sebastian,Sandhya G. Rani,Somak Ray,C. J. Harrys Kishore,Sashi Kanth,Mukhtar Ahmed,Manoj Kumar Kashyap,Manoj Kumar Kashyap,Riaz Mohmood,Y. L. Ramachandra,Venkatarangaiah Krishna,B. Abdul Rahiman,Subburaman Mohan,Prathibha Ranganathan,Subhashri Ramabadran,Raghothama Chaerkady,Akhilesh Pandey +31 more
TL;DR: A number of new features in HPRD are added, including PhosphoMotif Finder, which allows users to find the presence of over 320 experimentally verified phosphorylation motifs in proteins of interest, and a protein distributed annotation system—Human Proteinpedia.
Journal ArticleDOI
Single-Cell Transcriptomic Analysis of Tumor-Derived Fibroblasts and Normal Tissue-Resident Fibroblasts Reveals Fibroblast Heterogeneity in Breast Cancer.
Aimy Sebastian,Nicholas R. Hum,Nicholas R. Hum,Kelly A. Martin,Sean F. Gilmore,Ivana Peran,Stephen W. Byers,Elizabeth K. Wheeler,Matthew A. Coleman,Gabriela G. Loots,Gabriela G. Loots,Gabriela G. Loots +11 more
TL;DR: Understanding of CAF heterogeneity in triple-negative breast cancer is enhanced, and specifically targeting these CAF subpopulations could be an effective therapeutic approach for treating highly aggressive TNBCs.
Journal ArticleDOI
Transcriptional control of Sost in bone.
TL;DR: The current understanding of the upstream molecular mechanisms that regulate Sost/SOST transcription, in bone is reviewed and may unveil new avenues for therapeutic approaches.
Journal ArticleDOI
Global molecular changes in a tibial compression induced ACL rupture model of post-traumatic osteoarthritis.
Jiun C. Chang,Aimy Sebastian,Deepa K. Murugesh,Sarah J. Hatsell,Aris N. Economides,Blaine A. Christiansen,Gabriela G. Loots +6 more
TL;DR: This study provides the first account of gene expression changes associated with PTOA development and progression in a TC model, and suggests that the TC model may be a more rapidly progressing model of PtoA.
Journal ArticleDOI
Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner
Nicole M. Collette,Cristal S. Yee,Cristal S. Yee,Deepa K. Murugesh,Aimy Sebastian,Aimy Sebastian,Leila Taher,Leila Taher,Nicholas W. Gale,Aris N. Economides,Richard M. Harland,Gabriela G. Loots,Gabriela G. Loots +12 more
TL;DR: It is shown that Sost and its paralog Sostdc1 emerged through ancestral genome duplication and their expression patterns have diverged to delineate non-overlapping domains in most organ systems including musculoskeletal, cardiovascular, nervous, digestive, reproductive and respiratory.