A
Aisling Kennedy
Researcher at University College Dublin
Publications - 10
Citations - 906
Aisling Kennedy is an academic researcher from University College Dublin. The author has contributed to research in topics: Tumor necrosis factor alpha & Inflammatory arthritis. The author has an hindex of 9, co-authored 10 publications receiving 772 citations.
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Journal ArticleDOI
Synovial tissue hypoxia and inflammation in vivo
Chin Teck Ng,Monika Biniecka,Aisling Kennedy,J. McCormick,Oliver FitzGerald,Barry Bresnihan,Donal J. Buggy,Cormac T. Taylor,Jacintha O'Sullivan,Ursula Fearon,Douglas J. Veale +10 more
TL;DR: This is the first study to show a direct in vivo correlation between synovial tPO2, inflammation and cell migration, thus it is proposed that hypoxia is a possible primary driver of inflammatory processes in the arthritic joint.
Journal ArticleDOI
Macrophages in synovial inflammation.
TL;DR: The current understanding of macrophages and macrophage polarization in RA as well as the elements implicated in controlling polarization, such as cytokines and transcription factors like NFκB, IRFs and NR4A, and pro-resolving factors, and other lipid mediators which may promote a non-inflammatory, pro- Resolving phenotype, and may represent a novel therapeutic paradigm are reviewed.
Journal ArticleDOI
Angiogenesis and blood vessel stability in inflammatory arthritis.
Aisling Kennedy,Chin Teck Ng,Monika Biniecka,Tajvur P Saber,Cormac T. Taylor,Jacintha O'Sullivan,Douglas J. Veale,Ursula Fearon +7 more
TL;DR: The findings indicate the presence of unstable vessels in inflamed joints associated with hypoxia, incomplete EC-pericyte interactions, and increased DNA damage to further drive this unstable microenvironment.
Journal ArticleDOI
Oxidative damage in synovial tissue is associated with in vivo hypoxic status in the arthritic joint
Monika Biniecka,Aisling Kennedy,Ursula Fearon,Chin Teck Ng,Douglas J. Veale,Jacintha O'Sullivan +5 more
TL;DR: Low oxygen tension in vivo, disease activity and angiogenic marker expression in inflammatory arthritis is associated with low lipid peroxidation in synovial fluid and tissue.
Journal ArticleDOI
Acute-phase serum amyloid A regulates tumor necrosis factor α and matrix turnover and predicts disease progression in patients with inflammatory arthritis before and after biologic therapy.
Mary Connolly,Ronan H Mullan,J. McCormick,Clare Matthews,Owen Sullivan,Aisling Kennedy,Oliver FitzGerald,A. Robin Poole,Barry Bresnihan,Douglas J. Veale,Ursula Fearon +10 more
TL;DR: The ability of A-SAA to regulate TNFα suggests that A- SAA signaling pathways may provide new therapeutic strategies for the treatment of inflammatory arthritis.