Author
Aisulu Mussagaliyeva
Bio: Aisulu Mussagaliyeva is an academic researcher. The author has contributed to research in topics: Lipid modification & Internal medicine. The author has an hindex of 3, co-authored 3 publications receiving 1855 citations.
Topics: Lipid modification, Internal medicine, Medicine, QRS complex, Cardiology
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4,069 citations
Journal Article•
42 citations
TL;DR: In this paper , the impact of adherence to the Atrial fibrillation better care (ABC) pathway on major outcomes was analyzed through Cox-regression analyses and delay of event (DoE) analyses.
Abstract: Clinical complexity is increasingly prevalent among patients with atrial fibrillation (AF). The 'Atrial fibrillation Better Care' (ABC) pathway approach has been proposed to streamline a more holistic and integrated approach to AF care; however, there are limited data on its usefulness among clinically complex patients. We aim to determine the impact of ABC pathway in a contemporary cohort of clinically complex AF patients.From the ESC-EHRA EORP-AF General Long-Term Registry, we analysed clinically complex AF patients, defined as the presence of frailty, multimorbidity and/or polypharmacy. A K-medoids cluster analysis was performed to identify different groups of clinical complexity. The impact of an ABC-adherent approach on major outcomes was analysed through Cox-regression analyses and delay of event (DoE) analyses.Among 9966 AF patients included, 8289 (83.1%) were clinically complex. Adherence to the ABC pathway in the clinically complex group reduced the risk of all-cause death (adjusted HR [aHR]: 0.72, 95%CI 0.58-0.91), major adverse cardiovascular events (MACEs; aHR: 0.68, 95%CI 0.52-0.87) and composite outcome (aHR: 0.70, 95%CI: 0.58-0.85). Adherence to the ABC pathway was associated with a significant reduction in the risk of death (aHR: 0.74, 95%CI 0.56-0.98) and composite outcome (aHR: 0.76, 95%CI 0.60-0.96) also in the high-complexity cluster; similar trends were observed for MACEs. In DoE analyses, an ABC-adherent approach resulted in significant gains in event-free survival for all the outcomes investigated in clinically complex patients. Based on absolute risk reduction at 1 year of follow-up, the number needed to treat for ABC pathway adherence was 24 for all-cause death, 31 for MACEs and 20 for the composite outcome.An ABC-adherent approach reduces the risk of major outcomes in clinically complex AF patients. Ensuring adherence to the ABC pathway is essential to improve clinical outcomes among clinically complex AF patients.
13 citations
Geneva College1, University of Oxford2, University of Milan3, University of Bern4, University of Paris5, National Institutes of Health6, Ghent University7, Leiden University Medical Center8, University of Cambridge9, Trinity College, Dublin10, Charité11, Queen Mary University of London12, Oslo University Hospital13, Brigham and Women's Hospital14, University of Helsinki15, Hacettepe University16, University of Gothenburg17
13 citations
TL;DR: In this paper , the clinical and hemodynamic effects of cardiac resynchronization therapy in patients with congestive heart failure were evaluated and a significant increase in left ventricular ejection fraction (35.4±3.7%, p < 0.001, compared with baseline) and decrease in end-systolic volume of the left ventricle was observed.
Abstract: The aim of the study was to evaluate the clinical and hemodynamic effects of resynchronization therapy in patients with congestive heart failure. Materials and methods: Seventy-six consecutive patients underwent echocardiography, NYHA classification, 6-minute walk test and clinical assessment scale modified by Mareev, before and after cardiac resynchronization therapy. All had complete left bundle branch block, with a QRS complex duration ≥ 130 ms. and left ventricular ejection fraction ≤ 35%. Also, all patients had received optimal medical therapy for at least 3 months before inclusion to the study. Results: We observed significant increase in left ventricular ejection fraction (35.4±3.7%, p < 0.001, compared with baseline) and decrease in end-systolic volume of the left ventricle (20.2 ±3.0 %, p < 0.001 compared with baseline). Improvement in functional class of congestive heart failure by NYHA classification by > 1 was observed in 68.4% of individuals, in 26.3% of participants demonstrated no change and 5.3% of patients had worsening of CHF symptoms. Conclusions: The response of patients with congestive heart failure to cardiac resynchronization therapy is heterogeneous. The relationship between left ventricular reverse remodeling and the functional class of the congestive heart failure was not significant. Key words: congestive heart failure, cardiac resynchronizing therapy, optimal drug therapy.
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TL;DR: A correction has been published: European Heart Journal, ehaa895, https://doi.org/10.1093/eurheartj/ehaa-895.
Abstract: A correction has been published: European Heart Journal, ehaa895, https://doi.org/10.1093/eurheartj/ehaa895
2,361 citations
Maastricht University1, University of Bologna2, University of Melbourne3, University of Leicester4, Federation University Australia5, University of British Columbia6, Imperial College London7, University of London8, Public Health Foundation of India9, University of Western Australia10, Baker IDI Heart and Diabetes Institute11, National and Kapodistrian University of Athens12, Manchester Academic Health Science Centre13, University of Manchester14, Boston University15, University College London16, University of New South Wales17, The George Institute for Global Health18, North-West University19
TL;DR: Document reviewers: Hind Beheiry (Sudan), Irina Chazova (Russia), Albertino Damasceno (Mozambique), Anna Dominiczak (UK), Stephen Harrap (Australia), Hiroshi Itoh (Japan), Tazeen Jafar (Singapore), Marc Jaffe (USA), Patricio Jaramillo-Lopez (Colombia), Kazuomi Kario (Japan).
Abstract: Document reviewers: Hind Beheiry (Sudan), Irina Chazova (Russia), Albertino Damasceno (Mozambique), Anna Dominiczak (UK), Anastase Dzudie (Cameroon), Stephen Harrap (Australia), Hiroshi Itoh (Japan), Tazeen Jafar (Singapore), Marc Jaffe (USA), Patricio Jaramillo-Lopez (Colombia), Kazuomi Kario (Japan), Giuseppe Mancia (Italy), Ana Mocumbi (Mozambique), Sanjeevi N.Narasingan (India), Elijah Ogola (Kenya), Srinath Reddy (India), Ernesto Schiffrin (Canada), Ann Soenarta (Indonesia), Rhian Touyz (UK), Yudah Turana (Indonesia), Michael Weber (USA), Paul Whelton (USA), Xin Hua Zhang, (Australia), Yuqing Zhang (China).
1,657 citations
1,650 citations
1,300 citations
Sahlgrenska University Hospital1, University of Paris2, National Institutes of Health3, Children's Hospital Oakland Research Institute4, University of Glasgow5, Aarhus University6, Centro Nacional de Investigaciones Cardiovasculares7, Medical University of Vienna8, University of Amsterdam9, University of California, Los Angeles10, University of Western Ontario11, Monash University12, University of Copenhagen13, Royal Perth Hospital14, University of Western Australia15, French Institute of Health and Medical Research16, Oregon Health & Science University17, University of Cambridge18, University of Bristol19, Trinity College, Dublin20, University of Texas Southwestern Medical Center21, Charité22, Utrecht University23, University of the Witwatersrand24, Imperial College London25, Technische Universität München26, University of Helsinki27, University of Groningen28, Hacettepe University29, University of Milan30, Columbia University31
TL;DR: In this paper, the authors proposed a method to solve the problem of the problem: this paper ] of "uniformity" of the distribution of data points in the data set.
Abstract: Abstract
655 citations