Ajeeta B. Dash

TL;DR: It is demonstrated that bone-marrow-derived human mesenchymal stem cells, when mixed with otherwise weakly metastatic human breast carcinoma cells, cause the cancer cells to increase their metastatic potency greatly when this cell mixture is introduced into a subcutaneous site and allowed to form a tumour xenograft.

TL;DR: Functional similarity of the stem cell populations was observed, with each different cell population expressing the cell type-specific markers beta-tubulin, type II collagen, and desmin, and demonstrating endothelial tube formation when cultured under conditions favoring neural, cartilage, muscle, and endothelial cell differentiation, respectively.

TL;DR: Findings support MRD- status as a relevant endpoint during maintenance and confirm the increased progression risk in patients converting to MRD+ from MRd- status, because MRD dynamics over time substantially impact PFS risk.

TL;DR: In this article, methods and compositions for treating a subject afflicted with breast cancer using a CXCR4 antagonist and optionally in combination with a chemotherapeutic agent were described.