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Akhmad Irhas Robby

Bio: Akhmad Irhas Robby is an academic researcher from Korea National University of Transportation. The author has contributed to research in topics: Photothermal therapy & Biosensor. The author has an hindex of 9, co-authored 12 publications receiving 149 citations.

Papers
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Journal ArticleDOI
TL;DR: A system to utilize poly(vinylpyrrolidone) and catechol chemistry (PVP@Ag:FCD) in order to avoid the fluorescence quenching of the FCD-AgNP combination due to Forster Resonance Energy Transfer (FRET).

38 citations

Journal ArticleDOI
TL;DR: PTX was selectively released from PD-TPP in cancer cells, reducing cell viability and causing enhanced apoptosis of cancer cells compared to normal cells, and this approach could be a potential strategy to enhance therapeutic efficacy of cancer drugs and minimize the side effects on normal cells.

37 citations

Journal ArticleDOI
TL;DR: In this paper, the authors describe the design of a wireless electrochemical and luminescent sensor for bacteria detection using surface-coatable electrochemically generated fluorescent carbon dots (FCDs), which were synthesized from a cationic polymer.

35 citations

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TL;DR: In this article, a self-healing hydrogel with pH-dependent controllable properties was designed by employing the pH-driven "blooming-bridged" phenomenon between polydopamine (PDA) and the zwitterionic fluorescent carbon dot (ZFCD).
Abstract: Near infrared (NIR)-induced reversible self-healing hydrogel electronics with pH-dependent controllable properties was designed by employing the pH-driven “blooming-bridged” phenomenon between polydopamine (PDA) and the zwitterionic fluorescent carbon dot (ZFCD). This self-healing hydrogel (PDA@ZFCD-PNIPAAm) was synthesized by incorporating an NIR-responsive PDA-loaded zwitterionic fluorescent carbon dot (PDA@ZFCD) into a thermo-responsive PNIPAAm hydrogel, and further combined with wireless device to monitor self-healing and electronic property of hydrogel. The change in PDA@ZFCD-PNIPAAm hydrogel properties depended on the “blooming-bridged” effect of PDA@ZFCD, which controlled the photothermal release and intermolecular hydrogen bonding of PDA under different pH conditions. At the acidic and basic conditions (blooming-bridged state), PDA@ZFCD-PNIPAAm hydrogel displayed a self-healing behavior under NIR irradiation, which did not occur at a neutral pH (bloomless state) owing to different activation of photothermal heat under NIR irradiation with different hydrogel pore size. This hydrogel also demonstrated different thermal and electronic properties in different pH owing to the “bridged” phenomenon of PDA nanoparticles. Moreover, PDA@ZFCD-PNIPAAm hydrogel indicated reversible fluorescence on/off, self-healing, and electronic properties as the pH conditions changed. In addition, the self-healing phenomenon of hydrogel and the change of its electronic property can be easily monitored in a smartphone as a real-time information via wireless sensor. Therefore, this approach offers new insight on the development of self-healing hydrogels with simple, rapid and real-time monitoring on self-healing behavior, which can be used for future applications of hydrogels.

30 citations

Journal ArticleDOI
TL;DR: The expression of alkaline phosphatase (ALP) from bacteria is utilized to design fluorescence ON/OFF system for bacteria detection, also using metal oxide nanoparticle for obtaining antibacterial activity and recyclability.

26 citations


Cited by
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Journal ArticleDOI
02 Dec 2019-Sensors
TL;DR: The latest advancements reviewed in this paper hold tremendous potential for the application of nanomaterials in the early screening of diseases and point-of-care testing.
Abstract: In recent years, an increasing number of nanomaterials have been explored for their applications in biomedical diagnostics, making their applications in healthcare biosensing a rapidly evolving field. Nanomaterials introduce versatility to the sensing platforms and may even allow mobility between different detection mechanisms. The prospect of a combination of different nanomaterials allows an exploitation of their synergistic additive and novel properties for sensor development. This paper covers more than 290 research works since 2015, elaborating the diverse roles played by various nanomaterials in the biosensing field. Hence, we provide a comprehensive review of the healthcare sensing applications of nanomaterials, covering carbon allotrope-based, inorganic, and organic nanomaterials. These sensing systems are able to detect a wide variety of clinically relevant molecules, like nucleic acids, viruses, bacteria, cancer antigens, pharmaceuticals and narcotic drugs, toxins, contaminants, as well as entire cells in various sensing media, ranging from buffers to more complex environments such as urine, blood or sputum. Thus, the latest advancements reviewed in this paper hold tremendous potential for the application of nanomaterials in the early screening of diseases and point-of-care testing.

129 citations

Journal ArticleDOI
TL;DR: Optical biosensors are rapid, real-time, and portable, have a low detection limit and a high sensitivity, and have a great potential for diagnosing various types of cancer as discussed by the authors.

107 citations

Journal ArticleDOI
TL;DR: In this paper , a review of recent advances in optical biosensors for early detection of cancer is presented, focusing on the design of various optical sensors using resonance, scattering, chemiluminescence, luminecence, interference, fluorescence, absorbance or reflectance and various fiber types.

107 citations

Journal ArticleDOI
TL;DR: Luminogens with aggregation-induced emission and their derived supramolecular systems with unique optical properties have been developed as fluorescent probes for turn-on sensing of pathogens with high sensitivity and specificity, offering great potential for not only light-up diagnosis of pathogen, but also image-guided PDI therapy for pathogenic infection.
Abstract: Pathogenic bacteria, fungi and viruses pose serious threats to the human health under appropriate conditions. There are many rapid and sensitive approaches have been developed for identification and quantification of specific pathogens, but many challenges still exist. Culture/colony counting and polymerase chain reaction are the classical methods used for pathogen detection, but their operations are time-consuming and laborious. On the other hand, the emergence and rapid spread of multidrug-resistant pathogens is another global threat. It is thus of utmost urgency to develop new therapeutic agents or strategies. Luminogens with aggregation-induced emission (AIEgens) and their derived supramolecular systems with unique optical properties have been developed as fluorescent probes for turn-on sensing of pathogens with high sensitivity and specificity. In addition, AIE-based supramolecular nanostructures exhibit excellent photodynamic inactivation (PDI) activity in aggregate, offering great potential for not only light-up diagnosis of pathogen, but also image-guided PDI therapy for pathogenic infection.

99 citations

Journal ArticleDOI
TL;DR: In this paper, the authors focus on the recent progress of the fabrication of a variety of transition metal-based materials integrated with carbon matrices for hydrogen evolution reaction (HER) and oxygen evolution reaction(OER) and overall water splitting.
Abstract: The development of highly efficient, low-cost and robust electrocatalysts for water splitting is urgently necessary to approach the energy crisis and environmental problems. In recent years, transition metal-based materials are commonly used as outstanding electrode materials for the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) due to their tunable electrocatalytic activity and earth-abundance. However, they are restrained from the disadvantages of low conductivity, easy agglomeration and poor stability. Therefore, it is a good choice to integrate transition metal compounds with carbon materials to address the aforementioned issues. In this review, we focus on the recent progress of the fabrication of a variety of transition metal-based materials integrated with carbon matrices for HER, OER and overall water splitting. First, the fundamentals of the water splitting process and the introduction of parameters to determine the water splitting performance are given. Then, the advantages of the integration of transition metals and compounds with carbon for electrolytic water splitting as well as the influence of the architecture, composition, electronic structure and interface engineering of the hybrid materials on their electrocatalytic activities are discussed. The experimental and theoretical simulation are complementary to investigate the mechanism of the enhanced HER, OER and overall water splitting processes. Finally, challenges, perspectives and opportunities for developing new transition metals and carbon-based electrocatalysts in water splitting are featured.

96 citations