A
Akihide Takeuchi
Researcher at Kyoto University
Publications - 27
Citations - 1305
Akihide Takeuchi is an academic researcher from Kyoto University. The author has contributed to research in topics: Gene & Alternative splicing. The author has an hindex of 17, co-authored 25 publications receiving 1179 citations. Previous affiliations of Akihide Takeuchi include Salk Institute for Biological Studies & Tokyo Medical and Dental University.
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Journal ArticleDOI
The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice
Eiji Kojima,Akihide Takeuchi,Masataka Haneda,Ayako Yagi,Tadao Hasegawa,Kenichi Yamaki,Kiyoshi Takeda,Shizuo Akira,Kaoru Shimokata,Ken-ichi Isobe +9 more
TL;DR: Results indicate that GADD34 works as a sensor of ER stress stimuli and recovers cells from shutoff of protein synthesis and up‐regulates Bip and CHOP in MEF of wild‐type mice.
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Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly
Takayuki Ohnishi,Takayuki Ohnishi,Masako Yanazawa,Tomoya Sasahara,Tomoya Sasahara,Yasuki Kitamura,Hidekazu Hiroaki,Yugo Fukazawa,Isao Kii,Takashi Nishiyama,Takashi Nishiyama,Akiyoshi Kakita,Hiroyuki Takeda,Akihide Takeuchi,Yoshie Arai,Yoshie Arai,Akane Ito,Hitomi Komura,Hitomi Komura,Hajime Hirao,Kaori Satomura,Kaori Satomura,Masafumi Inoue,Masafumi Inoue,Shin-ichi Muramatsu,Ko Matsui,Mari Tada,Michio Sato,Eri Saijo,Eri Saijo,Yoshiki Shigemitsu,Satoko Sakai,Satoko Sakai,Yoshitaka Umetsu,Natsuko Goda,Naomi Takino,Hitoshi Takahashi,Masatoshi Hagiwara,Tatsuya Sawasaki,Genji Iwasaki,Yu Nakamura,Yo-ichi Nabeshima,David B. Teplow,Minako Hoshi,Minako Hoshi,Minako Hoshi +45 more
TL;DR: A new neurotoxic mechanism that involves the interaction between patient-derived Aβ assemblies, termed amylospheroids, and the neuron-specific Na+/K+-ATPase α3 subunit (NAKα3) is revealed, which causes neurodegeneration through pre-synaptic calcium overload, which explains earlier observations that such neuronal hyperactivation is an early indicator of AD-related neurodegenersation.
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Heterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesis.
TL;DR: Results indicate that two functional alleles of Zfp148 are required for the normal development of fetal germ cells, and that p53 may be required for regulating p53 in the development of germ cells.
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Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia
Mayumi Yoshida,Naoyuki Kataoka,Kenjyo Miyauchi,Kenji Ohe,Kei Iida,Suguru Yoshida,Takayuki Nojima,Yukiko Okuno,Hiroshi Onogi,Tomomi Usui,Akihide Takeuchi,Takamitsu Hosoya,Tsutomu Suzuki,Masatoshi Hagiwara +13 more
TL;DR: It is found that the levels of modified uridine at the wobble position in cytoplasmic tRNAs are reduced in cells from patients with FD and that treatment with RECTAS increases the expression of IKAP and recovers the tRNA modifications.
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Cloning and Characterization of a Transcription Factor That Binds to the Proximal Promoters of the Two Mouse Type I Collagen Genes
TL;DR: DNA transfection experiments using fusion polypeptides with the yeast GAL4 DNA-binding segment indicated that the C-terminal part of BFCOL1 contained a potential transcriptional activation domain, and it is speculated that BFCol1 participates in the transcriptional control of the two type I collagen genes.