Akihisa Abe

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Simultaneously targeting two major intracellular protein degradation systems such as the ubiquitin-proteasome system by BZ and the autophagy-lysosomes system by a macrolide antibiotic enhances ER stress-mediated apoptosis in MM cells.

TL;DR: Upregulation of cdk4/cyclin D1 may be a primary and critical factor in induction of apoptosis in human lung carcinomas in vivo and inactivation of Rb protein renders cells more prone to apoptosis by abnormal expression of any cell‐cycle protein.