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Author

Akio Nakao

Bio: Akio Nakao is an academic researcher. The author has contributed to research in topics: Phenyl group & Glycidic acid. The author has an hindex of 1, co-authored 2 publications receiving 14 citations.
Topics: Phenyl group, Glycidic acid, Substituent, Alkyl

Papers
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Patent
13 Sep 1990
TL;DR: In this paper, a process for preparing optically active 3-phenylglycidic acid ester compound is described, which comprises permitting a culture broth, cells or treated cells of a microorganism having the ability of stereoselectively hydrolyzing a (2R, 3S)-3-PNE compound to act on a racemic 3-PNEster compound which may also have a substituent on the phenyl group.
Abstract: There is disclosed a process for preparing optically active 3-phenylglycidic acid ester compound, which comprises permitting a culture broth, cells or treated cells of a microorganism having an ability of stereoselectively hydrolyzing a (2R, 3S)-3-phenylglycidic acid ester compound to act on a racemic 3-phenylglycidic acid ester compound which may also have a substituent on the phenyl group, thereby hydrolyzing the (2R, 3S) optically active isomer and separating and collecting the (2S, 3R) antipode from the reaction mixture.

13 citations

Patent
31 Jul 1991
TL;DR: In this article, a racemic trans-3-phenyl glycidic acid of formula I (the ring A is phenyl capable of being substituted) including the compound having one or more substituents on the phenyl group is reacted with an alkanol (preferably a 2-8C alcohol such as methanol) in the presence of a hydrolase (e.g. a lipase originated from Candida cylindracea) to esterify either of a (2S,3R) isomer and a ( 2R
Abstract: PURPOSE:To obtain the subject compound as highly pure crystals useful as an intermediate for optically active benzothiazepines by a single process comprising reacting racemic trans-phenylglycidic acid with an alkanol in the presence of a hydrolase. CONSTITUTION:A racemic trans-3-phenylglycidic acid of formula I (the ring A is phenyl capable of being substituted) including the compound having one or more substituents on the phenyl group is reacted with an alkanol (preferably a 2-8C alcohol such as methanol) in the presence of a hydrolase (e.g. a lipase originated from Candida cylindracea) to esterify either of a (2S,3R) isomer and a (2R,3S) isomer, and the produced optically active ester of formula II (R is alkyl) is separated and collected. The esterification reaction is preferably performed in toluene, carbon tetrachlorocarbon, etc., as a solvent under an anhydrous condition at 30-40 deg.C. The racemic compound as the raw material is preferably racemic trans-3-(4-methylphenyl)glycidic acid.

1 citations


Cited by
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Patent
15 Dec 1998
TL;DR: In this paper, a method of separating edible oil from biological material is disclosed, where a biomass slurry containing microbial material in an aqueous suspension is collected, typically placed in a centrifuge and then in a homogenizer.
Abstract: A method of separating edible oil from biological material is disclosed. A biomass slurry containing microbial material in an aqueous suspension is collected. The slurry is typically placed in a centrifuge and then in a homogenizer. The resulting slurry is fed into a contacting device, such as a packed column, and mixed with a solvent that is essentially immiscible in water, for example hexane. The solvent extracts the oil from the biomass slurry and then separates from the slurry. Edible oil is recovered from the solvent and further processed.

173 citations

Patent
02 Feb 1994
TL;DR: In this article, a new 1-aryltriazolin(ethi)ones of the general formula (I) are described, where R 1 represents nitro or represents a radical, R 2 represents hydrogen, amino or cyano, or represents one of the radicals.
Abstract: The invention relates to new 1-aryltriazolin(ethi)ones of the general formula (I) ##STR1## in which R 1 represents nitro or represents a radical --NR 8 R 9 , R 2 represents hydrogen, amino or cyano, or represents one of the radicals --R 10 , --O--R 10 , --S--R 10 , --NR 10 R 11 , --N(R 11 )--CO--R 10 or --N═CR 10 R 11 , R 3 , R 6 and R 7 independently of one another each represent hydrogen, halogen or nitro, R 4 represents hydrogen, halogen, cyano or nitro, or represents one of the radicals --R 12 , --O--R 12 , --S--R 12 , --S(O)--R 12 , --SO 2 --R 12 , --SO--OR 12 , --SO--NR 11 R 12 , --CO--OR 12 , --CO--NR 11 R 12 , --O--SO 2 --R 12 , --N(R 11 )--SO 2 --R 12 , --NR 11 R 12 , --NH--P(O)(R 11 )(OR 12 ) or --NH--P(O)(OR 11 )(OR 12 ), R 5 represents nitro, cyano, halogen or halogenoalkyl, and X represents oxygen or sulphur, where R 8 and R 9 independently of one another each represent hydrogen or represent in each case optionally substituted alkyl, alkenyl, alkinyl, alkoxy, cycloalkyl, aryl or heterocyclyl, or represent, together with the nitrogen atom to which they are attached, an optionally substituted heterocycle, R 10 represents in each case optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aryl, arylalkyl or heterocyclyl, R 11 represents hydrogen or represents in each case optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, arylalkyl or aryl, and R 12 represents hydrogen or represents in each case optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aryl or heterocyclyl, to a number of processes for their preparation, to a number of new intermediates, and to their use as herbicides.

20 citations

Patent
10 Mar 2000
TL;DR: In this paper, a III-V compound semiconductor having a layer formed from a first III-v compound semiconductors expressed by the general formula InuGavAlwN (where u+v+w=1) was described, where the full width at half maximum of the (0004) reflection X-ray rocking curve of the second III-vectors was 700 seconds or less regardless of the direction of X-rays incidence.
Abstract: Provided is a III-V compound semiconductor having a layer formed from a first III-V compound semiconductor expressed by the general formula InuGavAlwN (where 0≦u≦1, 0≦v≦1, 0≦w≦1, u+v+w=1), a pattern formed on the layer from a material different not only from the first III-V compound semiconductor but also from a second III-V compound semiconductor hereinafter described, and a layer formed on the first III-V compound semiconductor and the pattern from the second III-V compound semiconductor expressed by the general formula InxGayAlzN (where 0≦x≦1, 0≦y≦1, 0≦x≦1, x+y+z=1), wherein the full width at half maximum of the (0004) reflection X-ray rocking curve of the second III-V compound semiconductor is 700 seconds or less regardless of the direction of X-ray incidence. In the III-V compound semiconductor, which is a high quality semiconductor, the occurrence of low angle grain boundaries is suppressed.

13 citations

Patent
04 Jun 2004
TL;DR: In this paper, the present invention generally relates to at least one precursor compound and derivatives thereof, a process for preparing a taxane, and a baccatin derivative, and is related to the present paper.
Abstract: The present invention generally relates to at least one precursor compound and derivatives thereof, a process for preparing a taxane, and a baccatin derivative.

11 citations

Patent
27 Feb 1998
TL;DR: In this article, a process for preparing an optically active trans-3-substituted glycidic acid ester compound of the formula (I) is described.
Abstract: A process for preparing an optically active trans-3-substituted glycidic acid ester compound of the formula (I): ##STR1## wherein ring A is a substituted or unsubstituted benzene ring, and R1 is an ester residue, which comprises: preparing a solution of one optical isomer (A) and the other optical isomer (B) of the ester compound (I), both of which are the optical isomers due to the asymmetric carbons at 2- and 3-positions, and an ester compound (B') which is different from the isomer (B) only in the ester residue R1, crystallizing the optical isomer (A) from the solution up to the extent that the optical isomer (A) is crystallized without the precipitation of the optical isomer (B) due to the presence of the ester compound (B') though the optical isomer (B) would precipitate if the ester compound (B') were not present, and isolating the crystals of the optical isomer (A), whereby a desired optical isomer (A) can be obtained in high purity and in a high yield such that the desired isomer can be crystallized until the concentration of the desired isomer in the mother liquor becomes very low as compared with conventional processes.

7 citations