Signaling Recognition Events with Fluorescent Sensors and Switches.

https://cyberleninka.org/article/n/933162.pdf

Hydrogels in drug delivery: progress and challenges

Molecular self-assembly is the spontaneous association of molecules under equilibrium conditions into stable, structurally well-defined aggregates joined by noncovalent bonds. Molecular self-assembly is ubiquitous in biological systems and underlies the formation of a wide variety of complex biological structures. Understanding self-assembly and the associated noncovalent interactions that connect complementary interacting molecular surfaces in biological aggregates is a central concern in structural biochemistry. Self-assembly is also emerging as a new strategy in chemical synthesis, with the potential of generating nonbiological structures with dimensions of 1 to 10(2) nanometers (with molecular weights of 10(4) to 10(10) daltons). Structures in the upper part of this range of sizes are presently inaccessible through chemical synthesis, and the ability to prepare them would open a route to structures comparable in size (and perhaps complementary in function) to those that can be prepared by microlithography and other techniques of microfabrication.

https://science.sciencemag.org/content/sci/254/5036/1312.full.pdf

Molecular self-assembly and nanochemistry: a chemical strategy for the synthesis of nanostructures.

Complexation Thermodynamics of Cyclodextrins.

Molecular self-assembly and nanochemistry: A chemical strategy for the synthesis of nanostructures

Stimulus-responsive hydrogels have previously been developed that display heat-, light-, pH- or redox-induced sol–gel transitions. Nakahata et al. develop a self-healing supramolecular hydrogel based on host–guest polymers in which redox potential can induce a reversible sol–gel phase transition.

/pdf/redox-responsive-self-healing-materials-formed-from-host-4hptt9jlep.pdf

Redox-responsive self-healing materials formed from host–guest polymers

THE importance of non-covalent interactions in biological systems motivates much of the current interest in supramolecular assemblies1. A classic example of a supermolecule is provided by the rotaxanes2–5, in which a molecular 'rotor' is threaded by a linear 'axle'. Previous examples have included cyclic crown ethers threaded by polymers6, paraquat–hydroquinone complexes7 and cyclodextrin complexes8,9. We found recently that α-cyclodextrin will form high yields of a crystalline complex with polyethylene glycol (PEG), and suggested that the PEG penetrates the 'beaker-like' tunnel of the cyclodextrin10,11. We report here the preparation of a compound in which several cyclodextrins are threaded on a single PEG chain and are trapped by capping the chain with bulky end groups. This brings a step closer the 'molecular abacus' proposed by Stoddart and coworkers7. We call this supramolecular assembly a 'molecular necklace'.

The molecular necklace: a rotaxane containing many threaded α-cyclodextrins

Cyclodextrins have been used as a cyclic component in the construction of supramolecular architectures. Recently they have been studied as a component in the construction of rotaxanes and catenanes. A cyclodextrin ring can translocate in some rotaxane and catenane structures. Therefore, much attention has been given to cyclodextrins as a component of molecular shuttles, motors, and machines. Attempts to design and synthesize molecular-level machines using cyclodextrins as a cyclic component are described.

Cyclodextrin-based molecular machines.

This chapter overviews molecular machines based on cyclodextrins (CDs). The categories of CD-based molecular machines, external stimuli for CD-based molecular machines, and typical examples of CD-based molecular machines are briefly described.

Cyclodextrin-based molecular machines

La cyclodextrine α forme avec des PEG de masses moleculaires variables des complexes cristallins stables jusqu'a 300°C dans lesquels 2 motifs ethylene oxyde sont lies a une cavite de la cyclodextrine α

Akira Harada

Papers

Redox-responsive self-healing materials formed from host–guest polymers

The molecular necklace: a rotaxane containing many threaded α-cyclodextrins

Cyclodextrin-based molecular machines.

Cyclodextrin-based molecular machines

Complex formation between poly(ethylene glycol) and α-cyclodextrin