Akira Inoue

Bio: Akira Inoue is an academic researcher from Okayama University. The author has contributed to research in topics: Control theory & Model predictive control. The author has an hindex of 21, co-authored 210 publications receiving 1745 citations.

Operator-based nonlinear feedback control design using robust right coprime factorization

Abstract: In this note, robust stabilization and tracking performance of operator based nonlinear feedback control systems are studied by using robust right coprime factorization. Specifically, a new condition of robust right coprime factorization of nonlinear systems with unknown bounded perturbations is derived. Using the new condition, a broader class of nonlinear plants can be controlled robustly. When the spaces of the nonlinear plant output and the reference input are different, a space change filter is designed, and in this case this note considers tracking controller design using the exponential iteration theorem.

Three-Year Follow-Up of an Alectinib Phase I/II Study in ALK-Positive Non-Small-Cell Lung Cancer: AF-001JP.

Abstract: Purpose Alectinib is an anaplastic lymphoma kinase (ALK) -specific kinase inhibitor that seems to be effective against non-small-cell lung cancer (NSCLC) with a variety of ALK mutations. The primary analysis of AF-001JP reported a promising overall response rate. To assess progression-free survival (PFS) and overall survival (OS), patients from the phase II part of AF-001JP were followed up for approximately 3 years. Patients and Methods Oral alectinib 300 mg was administered twice per day to patients with ALK inhibitor-naive, ALK-positive NSCLC who had progressed after one or more regimens of previous chemotherapy. In this long-term follow-up, efficacy (PFS, OS), correlation between tumor shrinkage and PFS, safety of alectinib, and relief of cancer symptoms were evaluated. Results At the updated data cutoff (September 10, 2015; first patient in August 30, 2011, last patient in April 18, 2012), 25 of 46 phase II patients were still receiving alectinib. Disease progression was confirmed in 18 patients (39%); median PFS was not reached (3-year PFS rate, 62%; 95% CI, 45 to 75). Fourteen patients had brain metastases at baseline; of these, 6 remained in the study without CNS and systemic progression. Tumor shrinkage and PFS showed no correlation. The 3-year OS rate was 78% (13 events). The most common treatment-related adverse event (all grades) was increased blood bilirubin (36.2%). Most cancer symptoms were relieved early, and medication for symptoms was dramatically decreased during alectinib therapy. Conclusion Alectinib was effective in this 3-year follow-up with a favorable safety profile over a long administration period in ALK-positive NSCLC without previous ALK inhibitor treatment.

Acute Korsakoff syndrome following mammillothalamic tract infarction.

Abstract: There are limited case reports of structural lesions causing Korsakoff syndrome. This report describes acute Korsakoff syndrome following localized, bilateral infarction of the mammillothalamic tracts (MTTs). Axial T2-weighted imaging revealed the lesions at the lateral wall level of the third ventricle and diffusion-weighted imaging confirmed that the left lesion was new and the right old. Korsakoff syndrome persisted 6 months after the onset. This case suggests that bilateral MTT dysfunction can lead to Korsakoff syndrome.

Networked non-linear control for an aluminum plate thermal process with time-delays

Abstract: This article considers networked non-linear control for an aluminum plate thermal process. This is done by using operator-based robust right coprime factorisation approach and Bezout identity to guarantee robust stable networked control system, as well as an operator-based tracking controller to ensure the controlled process output tracking the desired reference input. An experimental result is given for the case of temperature control of the aluminum plate thermal process.

Operator-based robust control for nonlinear systems with Prandtl-Ishlinskii hysteresis

Abstract: This article presents an operator-based robust control method for nonlinear systems with Prandtl-Ishlinskii (PI) hysteresis On the existence of the hysteresis, the system usually exhibits undesirable oscillations and even instability While addressing the hysteresis, PI model is adopted to describe it Especially, the PI model is decomposed into two terms: an invertible part and a disturbance part In this way, the invertible part could be considered as a part of the nonlinear system Based on the concept of Lipschitz's operator and the robust right coprime factorisation condition, a robust control design scheme is given to guarantee the bounded input bounded output stability of the obtained system Further, a tracking operator design method is given to ensure the control system output-tracking performance under the existence of the disturbance part Numerical simulation results are presented to validate the effectiveness of the proposed method

I and i

Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

A Survey of Fault Diagnosis and Fault-Tolerant Techniques—Part I: Fault Diagnosis With Model-Based and Signal-Based Approaches

Abstract: With the continuous increase in complexity and expense of industrial systems, there is less tolerance for performance degradation, productivity decrease, and safety hazards, which greatly necessitates to detect and identify any kinds of potential abnormalities and faults as early as possible and implement real-time fault-tolerant operation for minimizing performance degradation and avoiding dangerous situations. During the last four decades, fruitful results have been reported about fault diagnosis and fault-tolerant control methods and their applications in a variety of engineering systems. The three-part survey paper aims to give a comprehensive review of real-time fault diagnosis and fault-tolerant control, with particular attention on the results reported in the last decade. In this paper, fault diagnosis approaches and their applications are comprehensively reviewed from model- and signal-based perspectives, respectively.

Operations research at container terminals: a literature update

Abstract: The current decade sees a considerable growth in worldwide container transportation and with it an indispensable need for optimization. Also the interest in and availability of academic literatures as well as case reports are almost exploding. With this paper an earlier survey which proved to be of utmost importance for the community is updated and extended to provide the current state of the art in container terminal operations and operations research.

Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: case report

Abstract: This is a report of a 7-year-old girl suffering from widespread calvarial defects after severe head injury with multifragment calvarial fractures, decompressive craniectomy for refractory intracranial hypertension and replantation of cryopreserved skull fragments. Chronic infection resulted in an unstable skull with marked bony defects. Two years after the initial injury the calvarial defects were repaired. Due to the limited amount of autologous cancellous bone available from the iliac crest, autologous adipose derived stem cells were processed simultaneously and applied to the calvarial defects in a single operative procedure. The stem cells were kept in place using autologous fibrin glue. Mechanical fixation was achieved by two large, resorbable macroporous sheets acting as a soft tissue barrier at the same time. The postoperative course was uneventful and CT-scans showed new bone formation and near complete calvarial continuity three months after the reconstruction.

Modeling and Control of Piezo-Actuated Nanopositioning Stages: A Survey

Abstract: Piezo-actuated stages have become more and more promising in nanopositioning applications due to the excellent advantages of the fast response time, large mechanical force, and extremely fine resolution. Modeling and control are critical to achieve objectives for high-precision motion. However, piezo-actuated stages themselves suffer from the inherent drawbacks produced by the inherent creep and hysteresis nonlinearities and vibration caused by the lightly damped resonant dynamics, which make modeling and control of such systems challenging. To address these challenges, various techniques have been reported in the literature. This paper surveys and discusses the progresses of different modeling and control approaches for piezo-actuated nanopositioning stages and highlights new opportunities for the extended studies.