A
Alain Prochiantz
Researcher at Collège de France
Publications - 241
Citations - 23196
Alain Prochiantz is an academic researcher from Collège de France. The author has contributed to research in topics: Dopaminergic & engrailed. The author has an hindex of 69, co-authored 238 publications receiving 22194 citations. Previous affiliations of Alain Prochiantz include French Institute of Health and Medical Research & Chinese Academy of Sciences.
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Magnesium gates glutamate-activated channels in mouse central neurones
TL;DR: The voltage dependence of the NMDA receptor-linked conductance appears to be a consequence of the voltage dependenceof the Mg2+ block and its interpretation does not require the implication of an intramembrane voltage-dependent ‘gate’.
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The third helix of the Antennapedia homeodomain translocates through biological membranes
TL;DR: It is reported here that a polypeptide of 16 amino acids in length corresponding to the third helix of the homeodomain deleted of its N-terminal glutamate is still capable of translocating through the membrane, suggesting an energy-independent mechanism of translocation not involving classical endocytosis.
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Cell Internalization of the Third Helix of the Antennapedia Homeodomain Is Receptor-independent
Daniele Derossi,Sophie Calvet,Alain Trembleau,Alié Brunissen,Gérard Chassaing,Alain Prochiantz +5 more
TL;DR: The present demonstration, that a reverse helix and a helix composed of D-enantiomers still translocate across biological membranes at 4 and 37°C strongly suggests that the third helix of the homeodomain is internalized by a receptor-independent mechanism.
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Trojan peptides: the penetratin system for intracellular delivery
TL;DR: The unexpected properties of penetratins, a class of peptides with translocating properties and capable of carrying hydrophilic compounds across the plasma membrane, are summarized, allowing direct targeting of oligopeptides and oligonucleotides to the cytoplasm and nucleus.
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Antennapedia homeobox peptide regulates neural morphogenesis
TL;DR: The results demonstrate that neurons possess an efficient uptake system for the antennapedia homeobox peptide and suggest that binding of pAntp to consensus motifs present in nerve cell nuclei influences neuronal morphogenetic programs.