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Alan G. Porter
Researcher at National University of Singapore
Publications - 47
Citations - 8202
Alan G. Porter is an academic researcher from National University of Singapore. The author has contributed to research in topics: Apoptosis & Bacillus sphaericus. The author has an hindex of 29, co-authored 47 publications receiving 7674 citations.
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Journal ArticleDOI
Emerging roles of caspase-3 in apoptosis
Alan G. Porter,Reiner U. Jänicke +1 more
TL;DR: Caspase-3 is essential for certain processes associated with the dismantling of the cell and the formation of apoptotic bodies, but it may also function before or at the stage when commitment to loss of cell viability is made.
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Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis
TL;DR: Results indicate that although caspase-3 is not essential for TNF- or staurosporine-induced apoptosis, it is required for DNA fragmentation and some of the typical morphological changes of cells undergoing apoptosis.
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Caspase-3 Is Required for α-Fodrin Cleavage but Dispensable for Cleavage of Other Death Substrates in Apoptosis
TL;DR: It is suggested that caspase-3 is essential for cleavage of α-fodrin, but dispensable for the cleaved of PARP, Rb, PAK2, DNA-PKcs, gelsolin, and DFF-45 and imply that one or more caspases other than caspasing 2, 3, and 7 is activated and plays a crucial role in the cleaving of these substrates in MCF-7 cells.
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Mosquitocidal toxins of bacilli and their genetic manipulation for effective biological control of mosquitoes.
TL;DR: The results of cloning mosquitocidal toxins in heterologous microorganisms show the potential of expanding the range of susceptible mosquito species by combining several toxins of different host specificity in one cell, and the potential for increasing potency by persisting at the larval feeding zone.
Journal Article
Caspase-3 is essential for procaspase-9 processing and cisplatin-induced apoptosis of MCF-7 breast cancer cells.
Céline Blanc,Quinn Deveraux,Stanislaw Krajewski,Reiner U. Jänicke,Alan G. Porter,John C. Reed,Rolf Jaggi,Andreas Marti +7 more
TL;DR: It is shown that apoptosis of caspase-3-deficient MCF-7 breast cancer cells is defective in response to cisplatin treatment, as determined by chromatin condensation, nuclear fragmentation, DNA fragmentation, and release of cytochrome c from the mitochondria.