Author
Alan N. McLean
Other affiliations: NHS Greater Glasgow and Clyde, Monklands Hospital, University of Glasgow ...read more
Bio: Alan N. McLean is an academic researcher from Southern General Hospital. The author has contributed to research in topics: Functional electrical stimulation & Spinal cord injury. The author has an hindex of 17, co-authored 42 publications receiving 816 citations. Previous affiliations of Alan N. McLean include NHS Greater Glasgow and Clyde & Monklands Hospital.
Papers
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TL;DR: The suggestion that demographic profiles in SCI are subject to change is supported, in this population, of particular concern is the increasing number of older patients and those with high level tetraplegia, due to their increased care needs.
Abstract: Changing demographics of spinal cord injury over a 20-year period: a longitudinal population-based study in Scotland
99 citations
TL;DR: The Olympus LTF semiflexible fiberoptic thoracoscope combines features of both instruments, having a solid body and a flexible terminal section, and was evaluated for ease of use and compared diagnostic yield with closed needle biopsy.
77 citations
TL;DR: Oxygen cost and stimulation cost measures both allow discrimination between the efficacy of different muscle activation patterns during constant-power FES-cycling, and may find utility in the adjustment of stimulation patterns for achievement of optimal cycling performance.
53 citations
TL;DR: High resolution computed tomography has an established role in the investigation of diffuse parenchymal lung disease and bronchiectasis and the main disadvantages in the application of HRCT scanning in humans are radiation dose, the complexity of HR CT data analysis for the more complex edge finding algorithms, and technical problems over selection of phantoms.
Abstract: The plain chest radiograph, although useful in the assessment of acute asthma, mainly to exclude unsuspected pneumothorax, collapse or consolidation,1 2 is unable to demonstrate more subtle changes within the lungs of asthmatic patients. The ability of high resolution computed tomography (HRCT), with a theoretical resolution of 100 μm, to examine small structures within the chest is now being exploited in the investigation of asthma. Recent studies have focused on the visualisation of acute airway responses to bronchoconstrictor and bronchodilator stimuli as well as airway and lung parenchymal changes in chronic asthma.
High resolution computed tomography has evolved from a combination of improvements in scanner hardware and the software used to reconstruct the images. The single most important feature in improving the spatial resolution is the slice thickness or collimation. In practice this is usually 1–1.5 mm. The second important feature of HRCT is to reconstruct the image using a high spatial frequency algorithm. This decreases contrast resolution and increases the visibility of image noise, but it significantly improves spatial resolution.3 Other features of HRCT are quick scan times to reduce motion artefact, and the use of targeted reconstruction when necessary. These techniques allow selected areas of the lungs to be viewed at close to the inherent maximal spatial resolution of the scan system. The data are manipulated in digital form by sophisticated software to produce the final image. Lung slices can then be examined for evidence of airway and parenchymal lung disease according to recognised criteria. HRCT scanning now has an established role in the investigation of diffuse parenchymal lung disease and bronchiectasis.4 The main disadvantages in the application of HRCT scanning in humans are radiation dose, the complexity of HRCT data analysis for the more complex edge finding algorithms,5 and technical problems over selection of phantoms …
51 citations
TL;DR: This study demonstrates the variety of techniques and also the levels of histocytological yield and patient satisfaction that can be achieved and it is hoped that centres will adopt the methods that are shown to achieve the highest standards.
46 citations
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TL;DR: This article discusses the prevention of venous thromboembolism (VTE) and is part of the Antithrombotic and Thrombolytic Therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).
3,944 citations
TL;DR: This article discusses the prevention of venous thromboembolism (VTE) and is part of the Seventh American College of Chest Physicians Conference on Antithrombotic and Thrombolytic Therapy: Evidence-Based Guidelines.
3,064 citations
TL;DR: This work has shown that chronic inflammation in the different forms of Asthma can affect both the severity and duration of the symptoms of the disease and the treatment options for these conditions vary greatly.
Abstract: Introduction Acute Inflammation and Brief Symptoms Mechanisms: Experimentally Induced Allergic Reactions Clinical Consequences and Treatment Chronic Inflammation Site of the Inflammation in Asthma Cell Survival in Airway Tissues Characteristics of Chronic Inflammation Chronic Inflammation in the Different Forms of Asthma Clinic Consequences Treatment of Exacerbations Onset and Duration of Treatment Remodeling of the Airways Characteristics of Airways Remodeling in Asthma Clinical Consequences Radiographic Findings Treatment and Prevention of Airways Remodeling Conclusions
1,787 citations
TL;DR: The sensitivity of bronchoscopy is high for endobronchial disease and poor for peripheral lesions, while TTNA is associated with a higher rate of pneumothorax compared with bronchoscopic procedures and R-EBUS and EMN are emerging technologies for the diagnosis of peripheral lung cancer.
838 citations
687 citations