Albert Wettstein

Bio: Albert Wettstein is an academic researcher from Ciba Specialty Chemicals. The author has contributed to research in topics: Aldosterone & Yield (chemistry). The author has an hindex of 34, co-authored 141 publications receiving 3837 citations. Previous affiliations of Albert Wettstein include University of Basel.

Isolation from the adrenals of a new crystalline hormone with especially high effectiveness on mineral metabolism

Abstract: A new crystalline compound has been isolated from beef adrenal extracts. In three different assay methods using epinephrectomised rats or dogs it was found to be from 30 to 100 times as potent as cortexone (11-deoxy-corticosterone) or its acetate.

[Constitution of aldosterone, a new mineralocorticoid].

Abstract: Chemical degradation of the new crystalline mineralocorticoid provisionally called electrocortin has shown that this compound is 11β, 21-dihydroxy-3, 20-diketo-4-pregnen-18-al. In solution this reacts mainly as the 11-hemiacetal. We suggest aldosterone as a definitive name for the compound.

Über Steroide. 107. Mitteilung. Farbreaktionen mit Steroiden, insbesondere Corticosteroiden, im Papierchromatogramm

Abstract: Zum Nachweis von Steroiden, insbesondere Corticosteroiden auf Papierchromatogrammen, wird eine neue, sehr empfindliche Farbreaktion mit verdunnter Phosphorsaure beschrieben. Die sich ergebenden charakteristischen, verschiedenfarbigen UV.-Fluoreszenzen bedeuten, neben der Stellung der Steroide im Chromatogramm und ihrem Reduktionsvermogen, einen ausserst wertvollen Hinweis auf ihre Natur. In gewissen Fallen haben sich uns zu diesem Zweck auch die Reaktionen mit Antimon-trichlorid oder Anisaldehyd-Schwefelsaure gut bewahrt, die meist im weissen und UV.-Licht sichtbare Farben ergeben.

Aldosteron. Isolierung und Eigenschaften. Über Bestandteile der Nebennierenrinde und verwandte Stoffe. 91. Mitteilung

Abstract: Die Bestimmung von Aldosteron, seine Isolierung in Kristallen und seine Eigenschaften werden beschrieben.

Stoffwechselprodukte von Actinomyceten. 27. Mitteilung. Über die Konstitution von Ferrioxamin B

Abstract: Ferrioxamine B, the main sideramine type growth factor isolated from cultures of Streptomyces pilosus ETTLINGERet al., is a racemic trihydroxamate-iron(III) complex of the compound IV. The possible configurations for the iron(III) complex are Va–e.

Overview of Steroidogenic Enzymes in the Pathway from Cholesterol to Active Steroid Hormones

Abstract: Significant advances have taken place in our knowledge of the enzymes involved in steroid hormone biosynthesis since the last comprehensive review in 1988. Major developments include the cloning, identification, and characterization of multiple isoforms of 3β-hydroxysteroid dehydrogenase, which play a critical role in the biosynthesis of all steroid hormones and 17β-hydroxysteroid dehydrogenase where specific isoforms are essential for the final step in active steroid hormone biosynthesis. Advances have taken place in our understanding of the unique manner that determines tissue-specific expression of P450aromatase through the utilization of alternative promoters. In recent years, evidence has been obtained for the expression of steroidogenic enzymes in the nervous system and in cardiac tissue, indicating that these tissues may be involved in the biosynthesis of steroid hormones acting in an autocrine or paracrine manner. This review presents a detailed description of the enzymes involved in the biosynthe...

Siderophore-Based Iron Acquisition and Pathogen Control

Abstract: Summary: High-affinity iron acquisition is mediated by siderophore-dependent pathways in the majority of pathogenic and nonpathogenic bacteria and fungi. Considerable progress has been made in characterizing and understanding mechanisms of siderophore synthesis, secretion, iron scavenging, and siderophore-delivered iron uptake and its release. The regulation of siderophore pathways reveals multilayer networks at the transcriptional and posttranscriptional levels. Due to the key role of many siderophores during virulence, coevolution led to sophisticated strategies of siderophore neutralization by mammals and (re)utilization by bacterial pathogens. Surprisingly, hosts also developed essential siderophore-based iron delivery and cell conversion pathways, which are of interest for diagnostic and therapeutic studies. In the last decades, natural and synthetic compounds have gained attention as potential therapeutics for iron-dependent treatment of infections and further diseases. Promising results for pathogen inhibition were obtained with various siderophore-antibiotic conjugates acting as “Trojan horse” toxins and siderophore pathway inhibitors. In this article, general aspects of siderophore-mediated iron acquisition, recent findings regarding iron-related pathogen-host interactions, and current strategies for iron-dependent pathogen control will be reviewed. Further concepts including the inhibition of novel siderophore pathway targets are discussed.