Author
Alberto Fernández
Other affiliations: Hospital Clínico San Carlos, Technical University of Madrid
Bio: Alberto Fernández is an academic researcher from Complutense University of Madrid. The author has contributed to research in topics: Magnetoencephalography & Dementia. The author has an hindex of 37, co-authored 130 publications receiving 3806 citations. Previous affiliations of Alberto Fernández include Hospital Clínico San Carlos & Technical University of Madrid.
Papers published on a yearly basis
Papers
More filters
TL;DR: It is shown that the prefrontal area is selectively activated in humans during the perception of objects qualified as "beautiful" by the participants, which means aesthetics can be hypothetically considered as an attribute perceived by means of a particular brain processing system, in which the prefrontal cortex seems to play a key role.
Abstract: Visual aesthetic perception (“aesthetics”) or the capacity to visually perceive a particular attribute added to other features of objects, such as form, color, and movement, was fixed during human evolutionary lineage as a trait not shared with any great ape. Although prefrontal brain expansion is mentioned as responsible for the appearance of such human trait, no current knowledge exists on the role of prefrontal areas in the aesthetic perception. The visual brain consists of “several parallel multistage processing systems, each specialized in a given task such as, color or motion” [Bartels, A. & Zeki, S. (1999) Proc. R. Soc. London Ser. B 265, 2327–2332]. Here we report the results of an experiment carried out with magnetoencephalography which shows that the prefrontal area is selectively activated in humans during the perception of objects qualified as “beautiful” by the participants. Therefore, aesthetics can be hypothetically considered as an attribute perceived by means of a particular brain processing system, in which the prefrontal cortex seems to play a key role.
281 citations
TL;DR: The results suggest that spontaneous MEG rhythms are less complex in AD patients than in healthy control subjects, hence indicating an abnormal type of dynamics in AD.
145 citations
TL;DR: The results support the predominant role of the temporoparietal areas in the diagnosis of Alzheimer's disease and Magnetoencephalography and the source analysis of focal slow activity in particular provide interesting and potentially clinically useful tools to assess functional modifications of patients' brain and to evaluate its relationship with the cognitive status.
129 citations
Journal Article•
TL;DR: Results support the predominant role of temporoparietal hypofunction as defined by DD and hippocampal structural deficits shown on MR images in patients with AD, and support a multidisciplinary perspective of different techniques.
Abstract: BACKGROUND AND PURPOSE: Patients with Alzheimer disease (AD) have more low-frequency activity on conventional EEG and increased focal magnetoencephalographic (MEG) dipole density (DD) in delta and theta bands. This activity concurs with atrophy and reduced metabolic and perfusion rates, particularly in temporoparietal structures. The relationship between functional and structural measures and their conjoined capability to improve the diagnosis of AD were assessed in this study. METHODS: Whole-head MEG recordings were obtained in 15 patients in whom the diagnosis of AD had been made and in 16 healthy control subjects during a resting condition. MR imaging volumetric data were also obtained; these included global cerebral, temporal lobe, and hippocampal volumes. RESULTS: DD in the delta and theta bands was enhanced in the AD group compared with the healthy control subjects. Slow-wave activity differed significantly between the groups in the temporoparietal regions of both hemispheres. Left hippocampal volume was correlated with left temporal and parietal delta DD and left temporal theta DD. A combination of left hippocampal volume and left temporal theta DD enabled correct classification in 87.1% of the patients with AD or control subjects. CONCLUSION: Results support the predominant role of temporoparietal hypofunction as defined by DD and hippocampal structural deficits shown on MR images in patients with AD. A multidisciplinary perspective of different techniques may improve our understanding of the disease and our diagnostic abilities.
123 citations
TL;DR: Results demonstrated that the approach adopted for the calculation of a mean frequency score seems to be adequate and sensitive to detect differences between normal aging, cognitive deterioration and AD.
109 citations
Cited by
More filters
TL;DR: The development of brown adipose tissue with its characteristic protein, uncoupling protein-1 (UCP1), was probably determinative for the evolutionary success of mammals, as its thermogenesis enhances neonatal survival and allows for active life even in cold surroundings.
Abstract: Cannon, Barbara, and Jan Nedergaard. Brown Adipose Tissue: Function and Physiological Significance. Physiol Rev 84: 277–359, 2004; 10.1152/physrev.00015.2003.—The function of brown adipose tissue i...
5,470 citations
TL;DR: This review examines four broad areas of research within social cognitive neuroscience: (a) understanding others, (b) understanding oneself, (c) controlling oneself, and the processes that occur at the interface of self and others, and highlights two core-processing distinctions that can be neurocognitively identified across all of these domains.
Abstract: Social cognitive neuroscience examines social phenomena and processes using cognitive neuroscience research tools such as neuroimaging and neuropsychology. This review examines four broad areas of research within social cognitive neuroscience: (a) understanding others, (b) understanding oneself, (c) controlling oneself, and (d ) the processes that occur at the interface of self and others. In addition, this review highlights two core-processing distinctions that can be neurocognitively identified across all of these domains. The distinction between automatic versus controlled processes has long been important to social psychological theory and can be dissociated in the neural regions contributing to social cognition. Alternatively, the differentiation between internally-focused processes that focus on one’s own or another’s mental interior and externally-focused processes that focus on one’s own or another’s visible features and actions is a new distinction. This latter distinction emerges from social cognitive neuroscience investigations rather than from existing psychological theories demonstrating that social cognitive neuroscience can both draw on and contribute to social psychological theory.
1,737 citations
TL;DR: Comparing the SOS, Heat Shock, and Adaptive Regulatory Systems and evidence suggesting that UV mutagenesis does not require the induction of genes other than those repressed by LexA, the role of SOS processing to the spontaneous mutation frequency is suggested.
1,674 citations
TL;DR: There are a number of ways in which a clinical diagnosis of dementia of the Alzheimer type can be made – the application of clinical criteria is the commonest but ancillary techniques such as neuroima are also used.
Abstract: There are a number of ways in which a clinical diagnosis of dementia of the Alzheimer type can be made – the application of clinical criteria is the commonest but ancillary techniques such as neuroima
1,514 citations