Aldo H. Romero

Bio: Aldo H. Romero is an academic researcher. The author has contributed to research in topics: Nanotube & Magnetization. The author has an hindex of 1, co-authored 1 publications receiving 9 citations.

Uniaxial Magnetic Anisotropy Energy of Fe Wires Embedded in Carbon

Abstract: In this work, we analyze the magnetic anisotropy energy (MAE) of Fe cylinders embedded within zigzagcarbonnanotubes,bymeansofabinitiocalculations.Toseetheinfluenceoftheconfinement,wefixtheFe cylinder diameter and we follow the changes of the MAE as a function of the diameter of the nanotube, which contains the Fe cylinder. Wefind that the easy axis changes from parallel to perpendicular, with respect to the cylinder axis. The orientation change depends quite strongly on the confinement, which indicates a nontrivial dependence of the magnetization direction as function of the nanotube diameter. We alsofind that the MAE is affected by where the Fe cylinder sits with respect to the carbon nanotube, and the coupling between these two structures could also dominate the magnetic response. We analyze the thermal stability of the magnetization orientation of the Fe cylinder close to room temperature.

A nanogel based oral gene delivery system targeting SUMOylation machinery to combat gut inflammation

Abstract: Poor success rates and challenges associated with the current therapeutic strategies of inflammatory bowel disease (IBD) have accelerated the emergence of gene therapy as an alternative treatment option with great promise. However, oral delivery of nucleic acids (NAs) to an inflamed colon is challenged by multiple barriers presented by the gastrointestinal, extracellular and intracellular compartments. Therefore, we screened a series of polyaspartic acid-derived amphiphilic cationic polymers with varied hydrophobicity for their ability to deliver NAs into mammalian cells. Using the most effective TAC6 polymer, we then engineered biocompatible and stable nanogels composed of polyplexes (TAC6, NA) and an anionic polymer, sodium polyaspartate, that were able to deliver the NAs across mammalian cells using caveolae-mediated cellular uptake. We then utilized these nanogels for oral delivery of PIAS1 (protein inhibitor of activated STAT1), a SUMO 3 ligase, encoding plasmid DNA since PIAS1 is a key nodal therapeutic target for IBD due to its ability to control NF-κB-mediated inflammatory signaling. We show that plasmid delivery using TAC6-derived nanogels diminished gut inflammation in a murine colitis model. Therefore, our study presents engineering of orally deliverable nanogels that can target SUMOylation machinery to combat gut inflammation with very high efficacy.

Finite size effects on the magnetocrystalline anisotropy energy in Fe magnetic nanowires from first principles

Abstract: The geometric and the electronic structures, the magnetic moments, and the magnetocrystalline anisotropy energy of bcc-Fe nanowires with z-axis along the (110) direction are calculated in the framework of ab initio theories. In particular, we report a systematic study of free standing nanowires with geometries and sizes ranging from diatomic to 1 nm wide with 31 atoms per unit cell. We found that for nanowires with less than 14 atoms per unit cell, the ground-state structure is body-centered tetragonal. We also calculated the contributions of the dipolar magnetic energy to the magnetic anisotropy energy and found that in some cases, this contribution overcomes the magnetocrystalline part, determining thereby the easy axis direction. These results emphasize the importance and competition between both contributions in low dimensional systems.

Stability of magnetic nanoparticles inside ferromagnetic nanotubes

Abstract: During the last years great attention has been given to the encapsulation of magnetic nanoparticles. In this work we investigated the stability of small magnetic particles inside magnetic nanotubes. Multisegmented nanotubes were tested in order to optimize the stability of the particle inside the nanotubes. Our results evidenced that multisegmented nanotubes are more efficient to entrap the particles at temperatures up to hundreds of kelvins.

Confinement of magnetic nanoparticles inside multisegmented nanotubes by means of magnetic field gradients

Abstract: The possibility of confining magnetic nanoparticles inside multisegmented nanotubes by using strong field gradients is considered by means of Monte Carlo simulations. The problem is reduced to the random walk performed by the nanoparticle on the energy landscape produced by the tube’s magnetic field. The role of tube material, number of segments, and spacer thickness in the amount of time spent by the particle inside the tube is examined, concluding that it is possible to control the encapsulation time by using different architectures.

Impact of surface strain on the spin dynamics of deposited Co nanowires

Abstract: Tailoring the magnetic properties at atomic-scale is essential in the engineering of modern spintronics devices. One of the main concerns in the novel nanostructured materials design is the decrease of the paid energy in the way of functioning, but allowing to switch between different magnetic states with a relative low-cost energy at the same time. Magnetic anisotropy (MA) energy defines the stability of a spin in the preferred direction and is a fundamental variable in magnetization switching processes. Transition-metal wires are known to develop large, stable spin and orbital magnetic moments together with MA energies that are orders of magnitude larger than in the corresponding solids. Different ways of controlling the MA have been exploited such as alloying, surface charging, and external electrical fields. Here we investigate from a first-principle approach together with dynamic calculations, the surface strain driven mechanism to tune the magnetic properties of deposited nanowires. We consider as a...