A
Alejandra C. Ventura
Researcher at University of Buenos Aires
Publications - 41
Citations - 1122
Alejandra C. Ventura is an academic researcher from University of Buenos Aires. The author has contributed to research in topics: Cancer & Ultrasensitivity. The author has an hindex of 17, co-authored 40 publications receiving 1024 citations. Previous affiliations of Alejandra C. Ventura include Los Alamos National Laboratory & University of Michigan.
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Journal ArticleDOI
Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1.
Maria E. Gonzalez,Xin Li,Kathy A. Toy,Matthew L. DuPrie,Alejandra C. Ventura,Mousumi Banerjee,Mats Ljungman,Sofia D. Merajver,Celina G. Kleer +8 more
TL;DR: It is shown that EZH2 is important in ER-negative breast cancer growth in vivo and in vitro, and that BRCA1 is required for the proliferative effects of EZF2 and that blockade of EH2 may provide a prime target to prevent and/or halt ER- negative breast cancer progression.
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A Hidden Feedback in Signaling Cascades Is Revealed
TL;DR: A key feature of the new model is that a negative feedback emerges naturally, exerted between each cycle and its predecessor, and the system displays damped temporal oscillations under constant stimulation and propagates perturbations both forwards and backwards.
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Histone Methyltransferase EZH2 Induces Akt-Dependent Genomic Instability and BRCA1 Inhibition in Breast Cancer
Maria E. Gonzalez,Matthew L. DuPrie,Heather Krueger,Sofia D. Merajver,Alejandra C. Ventura,Kathy A. Toy,Celina G. Kleer +6 more
TL;DR: The results enable us to pinpoint one mechanism by which EZH2 regulates BRCA1 expression and genomic stability mediated by the PI3K/Akt-1 pathway.
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Signaling properties of a covalent modification cycle are altered by a downstream target.
Alejandra C. Ventura,Peng Jiang,Lauren D. Van Wassenhove,Domitilla Del Vecchio,Sofia D. Merajver,Alexander J. Ninfa +5 more
TL;DR: Examining the effects of a downstream target for one or both forms of the substrate of the covalent modification cycle affected the steady-state output of the system, the sensitivity of the response to the stimulus, and the concentration of the stimulus required to provide the half-maximal response (S50).
Journal ArticleDOI
Load-Induced Modulation of Signal Transduction Networks
Peng Jiang,Alejandra C. Ventura,Eduardo D. Sontag,Sofia D. Merajver,Alexander J. Ninfa,Domitilla Del Vecchio +5 more
TL;DR: The bandwidth, the range of frequency in which the system can process information, decreased in the presence of load, suggesting that downstream targets participate in establishing a balance between noise-filtering capabilities and a circuit’s ability to process high-frequency stimulation.