A
Alejandro Sweet-Cordero
Researcher at Stanford University
Publications - 31
Citations - 12150
Alejandro Sweet-Cordero is an academic researcher from Stanford University. The author has contributed to research in topics: KRAS & Cancer. The author has an hindex of 16, co-authored 22 publications receiving 11450 citations. Previous affiliations of Alejandro Sweet-Cordero include Boston Children's Hospital & Massachusetts Institute of Technology.
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Journal ArticleDOI
MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more
TL;DR: A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
Journal ArticleDOI
Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data
Marina Sirota,Joel T. Dudley,Joel T. Dudley,Jeewon Kim,Annie P. Chiang,Annie P. Chiang,Alexander A. Morgan,Alexander A. Morgan,Alejandro Sweet-Cordero,Julien Sage,Atul J. Butte,Atul J. Butte +11 more
TL;DR: A systematic computational approach to predict novel therapeutic indications on the basis of comprehensive testing of molecular signatures in drug-disease pairs for repositioning established drugs to treat a wide range of human diseases.
Journal ArticleDOI
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon
Kevin M. Haigis,Krystle R. Kendall,Yufang Wang,Ann Cheung,Marcia C. Haigis,Jonathan N. Glickman,Michiko Niwa-Kawakita,Alejandro Sweet-Cordero,Judith S. Sebolt-Leopold,Kevin Shannon,Jeffrey Settleman,Marco Giovannini,Tyler Jacks +12 more
TL;DR: Clear phenotypic differences between mutant Kras and Nras are demonstrated, and it is suggested that the oncogenic phenotype of mutant K-Ras might be mediated by noncanonical signaling through Ras effector pathways.
Journal ArticleDOI
An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis
Alejandro Sweet-Cordero,Sayan Mukherjee,Sayan Mukherjee,Aravind Subramanian,Han You,Jeffrey J Roix,Christine Ladd-Acosta,Jill P. Mesirov,Todd R. Golub,Tyler Jacks +9 more
TL;DR: A method for comparing mouse models of cancer with human tumors using gene-expression profiling was applied to the analysis of a model of Kras2-mediated lung cancer and found a good relationship to human lung adenocarcinoma, thereby validating the model.
Journal ArticleDOI
Requirement for Rac1 in a K-ras induced lung cancer in the mouse.
Joseph L. Kissil,Marita J. Walmsley,Linda Hanlon,Kevin M. Haigis,Carla F. Kim,Alejandro Sweet-Cordero,Matthew S. Eckman,David A. Tuveson,Anthony J. Capobianco,Victor L. J. Tybulewicz,Tyler Jacks +10 more
TL;DR: A model of lung cancer in which an oncogenic allele of K-ras could be activated by Cre-mediated recombination in the presence or absence of conditional deletion of Rac1 shows that Rac1 function is required for tumorigenesis in this model.