Author
Alemayehu Gashaw Woldegiorgis
Bio: Alemayehu Gashaw Woldegiorgis is an academic researcher from Zhejiang University. The author has contributed to research in topics: Enantioselective synthesis & Catalysis. The author has an hindex of 1, co-authored 2 publications receiving 2 citations.
Papers
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TL;DR: This protocol provides facile and efficient access to asymmetric construction of a broad range of axially chiral allene-derived naphthalenones bearing quaternary stereocenters in good yields with high diastereoselectivity and enantioselectivities.
19 citations
TL;DR: In this paper , an asymmetric Friedel-Crafts alkylation/transamidation tandem reaction was developed for the enantio- and diastereoselective synthesis of pyrazolo[3,4-b]pyridin-6-ones bearing a CF3 unit via synergistic chiral phosphoric acid and MgSO4 catalysis.
9 citations
8 citations
TL;DR: This asymmetric organocatalysis protocol enables efficient synthesis of unnatural α-amino acid derivatives with a tetrasubstituted stereogenic center and an alkyne moiety with up to 99% yield and 98% ee, resulting in operationally simple conditions, short reaction time, and broad substrate scope.
3 citations
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TL;DR: In this article , a review of the recent progress in the field of organocatalytic enantioselective synthesis of allenes (2000-2022) is presented.
Abstract: Axially chiral allenes occur on a wide range of natural products and synthetic molecules with significant biological activity. Furthermore, they are versatile building blocks in organic synthesis because of their inherent chemical properties. Accordingly, catalytic enantioselective synthesis of axially chiral allenes has been paid much attention. Benefited from the development of asymmetric organocatalysis, many simple and efficient methods in terms of different catalytic systems as well as reaction partners have been developed. This review will focus on the recent progress in the field of organocatalytic enantioselective synthesis of allenes (2000–2022), which is organized according to types of allenes and the catalyst system used.
21 citations
TL;DR: An asymmetric organocatalytic remote 1,10-addition of alkynyl indole imine methides generated in situ from α-(6-indolyl) propargylic alcohols with thiazolones has been developed for the first time, affording axially chiral tetrasubstituted allenes featuring vicinal sulfur-containing quaternary carbon stereocenters in high yields with excellent stereoselectivities.
12 citations
TL;DR: In this article, the authors summarize the recent development of chiral phosphoric acid-catalyzed synthesis of a wide range of axially chiral biaryls, heterobiaryls, vinylarenes, N-arylamines, spiranes, and allenes with high efficiency and excellent stereoselectivity.
Abstract: In recent years, the synthesis of axially chiral compounds has received considerable attention due to their extensive application as biologically active compounds in medicinal chemistry and as chiral ligands in asymmetric catalysis. Chiral phosphoric acids are recognized as efficient organocatalysts for a variety of enantioselective transformations. In this review, we summarize the recent development of chiral phosphoric acid-catalyzed synthesis of a wide range of axially chiral biaryls, heterobiaryls, vinylarenes, N-arylamines, spiranes, and allenes with high efficiency and excellent stereoselectivity.
12 citations
TL;DR: In this paper , an asymmetric Friedel-Crafts alkylation/transamidation tandem reaction was developed for the enantio- and diastereoselective synthesis of pyrazolo[3,4-b]pyridin-6-ones bearing a CF3 unit via synergistic chiral phosphoric acid and MgSO4 catalysis.
9 citations
8 citations