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Alessandra Sacco
Researcher at Discovery Institute
Publications - 45
Citations - 5361
Alessandra Sacco is an academic researcher from Discovery Institute. The author has contributed to research in topics: Skeletal muscle & Stem cell. The author has an hindex of 21, co-authored 42 publications receiving 4685 citations. Previous affiliations of Alessandra Sacco include Istituto Superiore di Sanità & Sanford-Burnham Institute for Medical Research.
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Journal ArticleDOI
Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture
Penney M. Gilbert,Karen Havenstrite,Klas E. G. Magnusson,Klas E. G. Magnusson,Alessandra Sacco,Nora Leonardi,Nora Leonardi,Peggy E. Kraft,N. K. Nguyen,Sebastian Thrun,Matthias P. Lutolf,Helen M. Blau +11 more
TL;DR: Using a bioengineered substrate to recapitulate key biophysical and biochemical niche features in conjunction with a highly automated single-cell tracking algorithm, it is shown that substrate elasticity is a potent regulator of MuSC fate in culture.
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Self-renewal and expansion of single transplanted muscle stem cells
Alessandra Sacco,Regis Doyonnas,Regis Doyonnas,Peggy E. Kraft,Stefan Vitorovic,Helen M. Blau +5 more
TL;DR: It is shown that the progeny of a single luciferase-expressing muscle stem cell can both self-renew and differentiate after transplantation in mice, providing new evidence at the clonal level that self-Renewal is an autonomous property of asingle adult muscle stem Cell.
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Reprogramming towards pluripotency requires AID-dependent DNA demethylation
Nidhi Bhutani,Jennifer J. Brady,Mara Damian,Alessandra Sacco,Stéphane Y. Corbel,Helen M. Blau +5 more
TL;DR: It is shown that reprogramming towards pluripotency in single heterokaryons is initiated without cell division or DNA replication, rapidly (1 day) and efficiently (70%) and new evidence is provided that mammalian AID is required for active DNA demethylation and initiation of nuclear reprograming towards pluripsetency in human somatic cells.
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Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice
Alessandra Sacco,Foteini Mourkioti,Rose Tran,Jinkuk Choi,Michael E. Llewellyn,Peggy E. Kraft,Marina Shkreli,Scott L. Delp,Jason H. Pomerantz,Steven E. Artandi,Helen M. Blau +10 more
TL;DR: Data show that DMD progression results, in part, from a cell-autonomous failure of MuSC to maintain the damage-repair cycle initiated by dystrophin deficiency, and the essential role of MuSC function has therapeutic implications for DMD.
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STAT3 signaling controls satellite cell expansion and skeletal muscle repair
Matthew T. Tierney,Tufan Aydogdu,David Sala,Barbora Malecova,Sole Gatto,Pier Lorenzo Puri,Lucia Latella,Alessandra Sacco +7 more
TL;DR: The results of this study indicate that pharmacological manipulation of STAT3 activity can be used to counteract the functional exhaustion of satellite cells in pathological conditions, thereby maintaining the endogenous regenerative response and ameliorating muscle-wasting diseases.