Alessandra Scamporrino

TL;DR: It is demonstrated for the first time that atorvastatin but not pravastatin affected insulin release and mitochondrial metabolism due to the suppression of antioxidant defense system and induction of ROS production in pancreatic β-cell models, and mitochondrial oxidative stress is a key element in the pathogenesis of statin-related diabetes.

TL;DR: This work aimed to identify differentially expressed mRNAs and non‐coding RNAs in serum samples of biopsy‐diagnosed mild and severe NAFLD patients with respect to controls and to each other.

TL;DR: Through computational analysis, it is observed that targets of both intracellular and extracellular DE miRNAs were involved in processes associated with the onset and progression of NAFLD and NASH, such as fatty acid metabolism, apoptosis and inflammation.

TL;DR: Subjects with NGT are not a homogeneous population, and they present different cardiovascular and glycometabolic risks.

TL;DR: The data support the hypothesis that lipotoxicity might contribute to L-cell deregulation, and indicate that a state of insulin resistance could be responsible for secretory alterations in L-cells through the impairment of insulin-signaling pathways.