A
Alessandro Fatica
Researcher at Sapienza University of Rome
Publications - 75
Citations - 8914
Alessandro Fatica is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Small nucleolar RNA & RNA. The author has an hindex of 34, co-authored 68 publications receiving 7424 citations. Previous affiliations of Alessandro Fatica include Wellcome Trust & University of Edinburgh.
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Journal ArticleDOI
Long non-coding RNAs: new players in cell differentiation and development
Alessandro Fatica,Irene Bozzoni +1 more
TL;DR: The function of lncRNAs in developmental processes, such as in dosage compensation, genomic imprinting, cell differentiation and organogenesis, with a particular emphasis on mammalian development are described.
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Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis
Ivano Legnini,Gaia Di Timoteo,Francesca Rossi,Mariangela Morlando,Francesca Briganti,Olga Sthandier,Alessandro Fatica,Tiziana Santini,Adrian Andronache,Mark Wade,Pietro Laneve,Nikolaus Rajewsky,Irene Bozzoni,Irene Bozzoni +13 more
TL;DR: One of them, circ-ZNF609, resulted in specifically controlling myoblast proliferation and is associated with heavy polysomes, providing an example of a protein-coding circRNA in eukaryotes.
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A Minicircuitry Comprised of MicroRNA-223 and Transcription Factors NFI-A and C/EBPα Regulates Human Granulopoiesis
Francesco Fazi,Alessandro Rosa,Alessandro Fatica,Vania Gelmetti,Maria Laura De Marchis,Clara Nervi,Irene Bozzoni +6 more
TL;DR: The data indicate that miR-223 plays a crucial role during granulopoiesis and point to the NFI-A repression as an important molecular pathway mediating gene reprogramming in this cell lineage.
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The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte/macrophage differentiation.
Alessandro Rosa,Monica Ballarino,Antonio Sorrentino,Olga Sthandier,F. De Angelis,Marcella Marchioni,B. Masella,Anna Guarini,Alessandro Fatica,Cesare Peschle,Irene Bozzoni +10 more
TL;DR: The interplay among these three components was demonstrated in myeloid cell lines as well as in human CD34+ differentiation, and data point to the important role of miR-424 and NFI-A in controlling the monocyte/macrophage differentiation program.
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Isolation and characterization of CD146+ multipotent mesenchymal stromal cells.
Antonio Sorrentino,Manuela Ferracin,Germana Castelli,Mauro Biffoni,Giada Tomaselli,Marta Baiocchi,Alessandro Fatica,Massimo Negrini,Cesare Peschle,Mauro Valtieri +9 more
TL;DR: CD146(+) MSCs may represent a tool to explore the MSC-HSC cross-talk in an in vitro surrogate model for HSC "niches," and for regenerative therapy studies.