A
Alessandro Padovani
Researcher at University of Brescia
Publications - 799
Citations - 31274
Alessandro Padovani is an academic researcher from University of Brescia. The author has contributed to research in topics: Dementia & Frontotemporal dementia. The author has an hindex of 77, co-authored 712 publications receiving 24844 citations. Previous affiliations of Alessandro Padovani include Sapienza University of Rome & University of Pavia.
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Journal ArticleDOI
Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly
Annamaria Cattaneo,Nadia Cattane,Samantha Galluzzi,Stefania Provasi,Nicola Lopizzo,Cristina Festari,Clarissa Ferrari,Ugo Paolo Guerra,Barbara Paghera,Cristina Muscio,Angelo Bianchetti,Giorgio Dalla Volta,Marinella Turla,Maria Cotelli,Michele Gennuso,Alessandro Prelle,Orazio Zanetti,Giulia Lussignoli,Dario Mirabile,Daniele Bellandi,Simona Gentile,Gloria Belotti,Daniele Villani,Taoufiq Harach,Tristan Bolmont,Alessandro Padovani,Marina Boccardi,Giovanni B. Frisoni +27 more
TL;DR: The data indicate that an increase in the abundance of a pro-inflammatory GMB taxon, Escherichia/Shigella, and a reduction in the abundances of an anti-inflammatoryTaxon, E. rectale, are possibly associated with a peripheral inflammatory state in patients with cognitive impairment and brain amyloidosis.
Journal ArticleDOI
Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study
Ian G. McKeith,John T. O'Brien,Zuzana Walker,Klaus Tatsch,Jan Booij,Jacques Darcourt,Alessandro Padovani,Raffaele Giubbini,Ubaldo Bonuccelli,Duccio Volterrani,Clive Holmes,Paul Kemp,Naji Tabet,Ines Meyer,Cornelia Reininger +14 more
TL;DR: The findings confirm the high correlation between abnormal (low binding) DAT activity measured with (123)I-FP-CIT SPECT and a clinical diagnosis of probable DLB and the diagnostic accuracy is sufficiently high for this technique to be clinically useful in distinguishing DLB from Alzheimer's disease.
Journal ArticleDOI
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy
Günter U. Höglinger,Nadine M. Melhem,Dennis W. Dickson,Patrick M. A. Sleiman,Li-San Wang,Lambertus Klei,Rosa Rademakers,Rohan de Silva,Irene Litvan,David E. Riley,John C. van Swieten,Peter Heutink,Zbigniew K. Wszolek,Ryan J. Uitti,Jana Vandrovcova,Howard I. Hurtig,Rachel G. Gross,Walter Maetzler,Stefano Goldwurm,Eduardo Tolosa,Barbara Borroni,Pau Pastor,Laura B. Cantwell,Mi Ryung Han,Allissa Dillman,Marcel P. van der Brug,J. Raphael Gibbs,J. Raphael Gibbs,Mark R. Cookson,Dena G. Hernandez,Dena G. Hernandez,Andrew B. Singleton,Matthew J. Farrer,Chang En Yu,Lawrence I. Golbe,Tamas Revesz,John Hardy,Andrew J. Lees,Bernie Devlin,Hakon Hakonarson,Ulrich Müller,Gerard D. Schellenberg,Roger L. Albin,Elena Alonso,Angelo Antonini,Manuela Apfelbacher,Steven E. Arnold,Jesús Avila,Thomas G. Beach,Sherry Beecher,Daniela Berg,Thomas D. Bird,Nenad Bogdanovic,Agnita J.W. Boon,Yvette Bordelon,Alexis Brice,Alexis Brice,Herbert Budka,Margherita Canesi,Wang Zheng Chiu,Roberto Cilia,Carlo Colosimo,Peter Paul De Deyn,Justo Garcãa De Yebenes,Laura Donker Kaat,Ranjan Duara,Alexandra Durr,Alexandra Durr,Sebastiaan Engelborghs,Giovanni Fabbrini,Nicole A. Finch,Robyn Flook,Matthew P. Frosch,Carles Gaig,Douglas Galasko,Thomas Gasser,Marla Gearing,Evan T. Geller,Bernardino Ghetti,Neill R. Graff-Radford,Murray Grossman,Deborah A. Hall,Lili-Naz Hazrati,Matthias Höllerhage,Joseph Jankovic,Jorge L. Juncos,Anna Karydas,Hans A. Kretzschmar,Isabelle Leber,Isabelle Leber,Virginia M.-Y. Lee,Andrew P. Lieberman,Kelly E. Lyons,Claudio Mariani,Eliezer Masliah,Luke A. Massey,Catriona McLean,Nicoletta Meucci,Bruce L. Miller,Brit Mollenhauer,Jens Carsten Möller,Huw R. Morris,Christopher Morris,Sean S. O'Sullivan,Wolfgang H. Oertel,Donatella Ottaviani,Alessandro Padovani,Rajesh Pahwa,Gianni Pezzoli,Stuart Pickering-Brown,Werner Poewe,Alberto Rábano,Alex Rajput,Stephen G. Reich,Gesine Respondek,Sigrun Roeber,Jonathan D. Rohrer,Owen A. Ross,Martin N. Rossor,Giorgio Sacilotto,William W. Seeley,Klaus Seppi,Laura Silveira-Moriyama,Salvatore Spina,Karin Srulijes,Peter St George-Hyslop,Maria Stamelou,David G. Standaert,Silvana Tesei,Wallace W. Tourtellotte,Claudia Trenkwalder,Claire Troakes,John Q. Trojanowski,Juan C. Troncoso,Vivianna M. Van Deerlin,Jean Paul G. Vonsattel,Gregor K. Wenning,Charles L. White,Pia Winter,Chris Zarow,Anna Zecchinelli +140 more
TL;DR: Two independent variants in MAPT affecting risk for PSP are confirmed, one of which influences MAPT brain expression and the genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface and for a myelin structural component.
Journal ArticleDOI
Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis
Wouter van Rheenen,Aleksey Shatunov,Annelot M. Dekker,Russell L. McLaughlin,Frank P. Diekstra,Sara L. Pulit,Rick A.A. van der Spek,Urmo Võsa,Simone de Jong,Simone de Jong,Matthew R. Robinson,Jian Yang,Isabella Fogh,Isabella Fogh,Perry T.C. van Doormaal,Gijs H.P. Tazelaar,Max Koppers,Anna M. Blokhuis,William Sproviero,Ashley R. Jones,Kevin P. Kenna,Kristel R. van Eijk,Oliver Harschnitz,Raymond D. Schellevis,William J. Brands,Jelena Medic,Androniki Menelaou,Alice Vajda,Alice Vajda,Nicola Ticozzi,Kuang Lin,Boris Rogelj,Katarina Vrabec,Metka Ravnik-Glavač,Blaž Koritnik,Janez Zidar,Lea Leonardis,Leja Dolenc Grošelj,Stéphanie Millecamps,François Salachas,Vincent Meininger,Mamede de Carvalho,Susana Pinto,Jesus S. Mora,Ricardo Rojas-García,Meraida Polak,Siddharthan Chandran,Shuna Colville,Robert Swingler,Karen E. Morrison,Pamela J. Shaw,John Hardy,Richard W. Orrell,Alan M. Pittman,Katie Sidle,Pietro Fratta,Andrea Malaspina,Simon Topp,Susanne Petri,Susanne Abdulla,Carsten Drepper,Michael Sendtner,Thomas F. Meyer,Roel A. Ophoff,Roel A. Ophoff,Roel A. Ophoff,Kim A. Staats,Martina Wiedau-Pazos,Catherine Lomen-Hoerth,Vivianna M. Van Deerlin,John Q. Trojanowski,Lauren Elman,Leo McCluskey,A. Nazli Basak,Ceren Tunca,Hamid Hamzeiy,Yesim Parman,Thomas Meitinger,Peter Lichtner,Milena Radivojkov-Blagojevic,Christian R. Andres,Cindy Maurel,Gilbert Bensimon,Bernhard Landwehrmeyer,Alexis Brice,Christine Payan,Safaa Saker-Delye,Alexandra Durr,Nicholas W. Wood,Lukas Tittmann,Wolfgang Lieb,Andre Franke,Marcella Rietschel,Sven Cichon,Markus M. Nöthen,Philippe Amouyel,Christophe Tzourio,Jean-François Dartigues,André G. Uitterlinden,Fernando Rivadeneira,Karol Estrada,Albert Hofman,Albert Hofman,Charles Curtis,Charles Curtis,Hylke M. Blauw,Anneke J. van der Kooi,Marianne de Visser,An Goris,Markus Weber,Christopher Shaw,Bradley N. Smith,Orietta Pansarasa,Cristina Cereda,Roberto Del Bo,Giacomo P. Comi,Sandra D'Alfonso,Cinzia Bertolin,Gianni Sorarù,Letizia Mazzini,Viviana Pensato,Cinzia Gellera,Cinzia Tiloca,Antonia Ratti,Andrea Calvo,Cristina Moglia,Maura Brunetti,Simona Arcuti,Rosa Capozzo,Chiara Zecca,Christian Lunetta,Silvana Penco,Nilo Riva,Alessandro Padovani,Massimiliano Filosto,Bernard Muller,Robbert Jan Stuit,Ian P. Blair,Katharine Y. Zhang,Emily P. McCann,Jennifer A. Fifita,Garth A. Nicholson,Garth A. Nicholson,Dominic B. Rowe,Roger Pamphlett,Matthew C. Kiernan,Julian Grosskreutz,Otto W. Witte,Thomas M. Ringer,Tino Prell,Beatrice Stubendorff,Ingo Kurth,Christian A. Hübner,P. Nigel Leigh,Federico Casale,Adriano Chiò,Ettore Beghi,Elisabetta Pupillo,Rosanna Tortelli,Giancarlo Logroscino,John Powell,Albert C. Ludolph,Jochen H. Weishaupt,Wim Robberecht,Philip Van Damme,Lude Franke,Tune H. Pers,Robert H. Brown,Jonathan D. Glass,John Landers,Orla Hardiman,Orla Hardiman,Peter M. Andersen,Peter M. Andersen,Philippe Corcia,Patrick Vourc'h,Vincenzo Silani,Naomi R. Wray,Peter M. Visscher,Paul I.W. de Bakker,Michael A. van Es,R. Jeroen Pasterkamp,Cathryn M. Lewis,Gerome Breen,Gerome Breen,Ammar Al-Chalabi,Leonard H. van den Berg,Jan H. Veldink +187 more
TL;DR: Evidence of ALS being a complex genetic trait with a polygenic architecture is established and the SNP-based heritability is estimated at 8.5%, with a distinct and important role for low-frequency variants (frequency 1–10%).
Journal ArticleDOI
Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis
Jonathan D. Rohrer,Jennifer M. Nicholas,Jennifer M. Nicholas,David M. Cash,John C. van Swieten,Elise G.P. Dopper,Lize C. Jiskoot,Rick van Minkelen,Serge A.R.B. Rombouts,M. Jorge Cardoso,Shona Clegg,Miklos Espak,Simon Mead,David L. Thomas,Enrico De Vita,Mario Masellis,Sandra E. Black,Morris Freedman,Ron Keren,Bradley J. MacIntosh,Ekaterina Rogaeva,David F. Tang-Wai,Maria Carmela Tartaglia,Robert Laforce,Fabrizio Tagliavini,Pietro Tiraboschi,Veronica Redaelli,Sara Prioni,Marina Grisoli,Barbara Borroni,Alessandro Padovani,Daniela Galimberti,Elio Scarpini,Andrea Arighi,Giorgio G. Fumagalli,James B. Rowe,Ian Coyle-Gilchrist,Caroline Graff,Caroline Graff,Marie Fallström,Vesna Jelic,Vesna Jelic,Anne Kinhult Ståhlbom,Anne Kinhult Ståhlbom,Christin Andersson,Christin Andersson,Håkan Thonberg,Håkan Thonberg,Lena Lilius,Giovanni B. Frisoni,Giuliano Binetti,Michela Pievani,Martina Bocchetta,Luisa Benussi,Roberta Ghidoni,Elizabeth Finger,Sandro Sorbi,Benedetta Nacmias,Gemma Lombardi,Cristina Polito,Jason D. Warren,Sebastien Ourselin,Nick C. Fox,Martin N. Rossor +63 more
TL;DR: Structural imaging and cognitive changes can be identified 5-10 years before expected onset of symptoms in asymptomatic adults at risk of genetic frontotemporal dementia, which could help to define biomarkers that can stage presymPTomatic disease and track disease progression.