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Alexander E Volk
Researcher at University of Hamburg
Publications - 76
Citations - 3868
Alexander E Volk is an academic researcher from University of Hamburg. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Frontotemporal dementia. The author has an hindex of 29, co-authored 67 publications receiving 2874 citations. Previous affiliations of Alexander E Volk include University of Ulm & University of Cologne.
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Journal ArticleDOI
Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia
Axel Freischmidt,Thomas Wieland,Benjamin Richter,Wolfgang Ruf,Veronique Schaeffer,Kathrin Muller,Nicolai Marroquin,Frida Nordin,Annemarie Hübers,Patrick Weydt,Susana Pinto,Rayomond Press,Stéphanie Millecamps,Nicolas Molko,Emilien Bernard,Claude Desnuelle,Marie-Hélène Soriani,Johannes Dorst,Elisabeth Graf,Ulrika Nordström,Marisa S. Feiler,Stefan Putz,Tobias M. Boeckers,Thomas F. Meyer,Andrea Sylvia Winkler,Juliane Winkelman,Mamede de Carvalho,Dietmar Rudolf Thal,Markus Otto,Thomas Brännström,Alexander E Volk,Petri Kursula,Karin M Danzer,Peter Lichtner,Ivan Dikic,Thomas Meitinger,Albert C. Ludolph,Tim M. Strom,Peter M Andersen,Jochen H. Weishaupt +39 more
TL;DR: It is concluded that haploinsufficiency of TBK1 causes ALS and fronto-temporal dementia.
Journal ArticleDOI
Neurofilaments in the diagnosis of motoneuron diseases: a prospective study on 455 patients
Petra Steinacker,Emily Feneberg,Jochen H. Weishaupt,Johannes Brettschneider,Hayrettin Tumani,Peter M. Andersen,Christine A. F. von Arnim,Sarah Böhm,Jan Kassubek,Christian Kubisch,Christian Kubisch,Dorothée Lulé,Hans-Peter Müller,Rainer Muche,Elmar H. Pinkhardt,Patrick Oeckl,Angela Rosenbohm,Sarah Anderl-Straub,Alexander E Volk,Alexander E Volk,Patrick Weydt,Albert C. Ludolph,Markus Otto +22 more
TL;DR: Neurofilaments in CSF have a high relevance for the differential diagnosis of MNDs and should be included in the diagnostic work-up of patients and their value as prognostic markers should be investigated further.
Journal ArticleDOI
Neurofilament levels as biomarkers in asymptomatic and symptomatic familial amyotrophic lateral sclerosis
Patrick Weydt,Patrick Oeckl,André Huss,Kathrin Muller,Alexander E Volk,Alexander E Volk,Jens Kuhle,Antje Knehr,Peter M. Andersen,Peter M. Andersen,Johannes Prudlo,Petra Steinacker,Jochen H. Weishaupt,Albert C. Ludolph,Markus Otto +14 more
TL;DR: In this article, the authors found that neurofilaments are elevated in cerebrospinal fluid (CSF) and serum of amyotrophic lateral sclerosis (ALS) patients.
Journal ArticleDOI
Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study.
Katrina M. Moore,Jennifer M. Nicholas,Murray Grossman,Corey T. McMillan,David J. Irwin,Lauren Massimo,Vivianna M. Van Deerlin,Jason D. Warren,Nick C. Fox,Martin N. Rossor,Simon Mead,Martina Bocchetta,Bradley F. Boeve,David S. Knopman,Neill Graff-Radford,Leah K. Forsberg,Rosa Rademakers,Zbigniew K. Wszolek,John C. van Swieten,Lize C. Jiskoot,Lieke H.H. Meeter,Elise G.P. Dopper,Janne M. Papma,Julie S. Snowden,Jennifer A. Saxon,Matthew Jones,Stuart Pickering-Brown,Isabelle Le Ber,Agnès Camuzat,Alexis Brice,Paola Caroppo,Roberta Ghidoni,Michela Pievani,Luisa Benussi,Giuliano Binetti,Bradford C. Dickerson,Diane Lucente,Samantha Krivensky,Caroline Graff,Linn Öijerstedt,Marie Fallström,Håkan Thonberg,Nupur Ghoshal,John C. Morris,Barbara Borroni,Alberto Benussi,Alessandro Padovani,Daniela Galimberti,Elio Scarpini,Giorgio G. Fumagalli,Giorgio G. Fumagalli,Ian R. Mackenzie,Ging-Yuek Robin Hsiung,Pheth Sengdy,Adam L. Boxer,Howie Rosen,Joanne Taylor,Matthis Synofzik,Matthis Synofzik,Carlo Wilke,Carlo Wilke,Patricia Sulzer,Patricia Sulzer,John R. Hodges,Glenda M. Halliday,John B.J. Kwok,Raquel Sánchez-Valle,Albert Lladó,Sergi Borrego-Écija,Isabel Santana,Maria Rosário Almeida,Miguel Tábuas-Pereira,Fermin Moreno,Myriam Barandiaran,Begoña Indakoetxea,Johannes Levin,Johannes Levin,Adrian Danek,James B. Rowe,Thomas E. Cope,Markus Otto,Sarah Anderl-Straub,Alexandre de Mendonça,Carolina Maruta,Mario Masellis,Sandra E. Black,Philippe Couratier,Géraldine Lautrette,Edward D. Huey,Sandro Sorbi,Benedetta Nacmias,Robert Laforce,Marie Pier L. Tremblay,Rik Vandenberghe,Philip Van Damme,Philip Van Damme,Emily Rogalski,Sandra Weintraub,Alexander Gerhard,Alexander Gerhard,Chiadi U. Onyike,Simon Ducharme,Sokratis G. Papageorgiou,Adeline Su Lyn Ng,Amy Brodtmann,Elizabeth Finger,Rita Guerreiro,Jose Bras,Jonathan D. Rohrer,Carolin Heller,Rhian S Convery,Ione O.C. Woollacott,Rachelle Shafei,Jonathan Graff-Radford,David T.W. Jones,Christina Dheel,Rodolfo Savica,Maria I. Lapid,Matt Baker,Julie A. Fields,Ralitza H. Gavrilova,Kimiko Domoto-Reilly,Jackie M. Poos,Emma L. van der Ende,Jessica L. Panman,Laura Donker Kaat,Harro Seelaar,Anna Richardson,Giovanni B. Frisoni,Anna Mega,Silvia Fostinelli,Huei Hsin Chiang,Antonella Alberici,Andrea Arighi,Chiara Fenoglio,Hilary W. Heuer,Bruce L. Miller,Anna Karydas,Jamie Fong,Maria João Leitão,Beatriz Santiago,Diana Duro,Carlos Ferreira,Alazne Gabilondo,Maria de Arriba,Mikel Tainta,Miren Zulaica,Catarina S. Ferreira,Elisa Semler,Albert C. Ludolph,Bernhard Landwehrmeyer,Alexander E Volk,Gabriel Miltenberger,Ana Verdelho,Sónia Afonso,Maria Carmela Tartaglia,Morris Freedman,Ekaterina Rogaeva,Camilla Ferrari,Irene Piaceri,Valentina Bessi,Gemma Lombardi,Frédéric St-Onge,Marie Claire Doré,Rose Bruffaerts,Mathieu Vandenbulcke,Jan Van den Stock,M.-Marsel Mesulam,Eileen H. Bigio,Christos Koros,John Papatriantafyllou,Christos Kroupis,Leonidas Stefanis,Christien Shoesmith,Erik Robertson,Giovanni Coppola,Eliana Marisa Ramos,Daniel H. Geschwind +177 more
TL;DR: An international study of age at symptom onset, age at death, and disease duration in individuals with mutations in GRN, MAPT, and C9orf72 to investigate the extent to which variability in age at onset and at death could be accounted for by family membership and the specific mutation carried.
Journal ArticleDOI
Neurofilament light chain in serum for the diagnosis of amyotrophic lateral sclerosis
Federico Verde,Petra Steinacker,Jochen H. Weishaupt,Jan Kassubek,Patrick Oeckl,Steffen Halbgebauer,Hayrettin Tumani,Christine A. F. von Arnim,Johannes Dorst,Emily Feneberg,Benjamin Mayer,Hans-Peter Müller,Martin Gorges,Angela Rosenbohm,Alexander E Volk,Vincenzo Silani,Albert C. Ludolph,Markus Otto +17 more
TL;DR: Serum NFL is increased in ALS in comparison to other conditions and can serve as diagnostic and prognostic biomarker and establish a cut-off level for the diagnosis of ALS.