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Alexander F. Schaapherder
Researcher at Leiden University Medical Center
Publications - 89
Citations - 5723
Alexander F. Schaapherder is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Transplantation & Kidney transplantation. The author has an hindex of 29, co-authored 83 publications receiving 4801 citations. Previous affiliations of Alexander F. Schaapherder include Loyola University Medical Center.
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Journal ArticleDOI
Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial
Marc G. Besselink,Hjalmar C. van Santvoort,Erik Buskens,Erik Buskens,Marja A. Boermeester,Harry van Goor,Harro M. Timmerman,Vincent B. Nieuwenhuijs,Thomas L. Bollen,Bert van Ramshorst,Ben J.M. Witteman,Camiel Rosman,Rutger J. Ploeg,Menno A. Brink,Alexander F. Schaapherder,Cornelis H. C. Dejong,Peter J. Wahab,Cees J. H. M. van Laarhoven,Erwin van der Harst,Casper H.J. van Eijck,Miguel A. Cuesta,Louis M. A. Akkermans,Hein G. Gooszen +22 more
TL;DR: In patients with predicted severe acute pancreatitis, probiotic prophylaxis with this combination of probiotic strains did not reduce the risk of infectious complications and was associated with an increased risk of mortality.
Journal Article
Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Commentary
Juhani Sand,Isto Nordback,Marc G. Besselink,Hjalmar C. van Santvoort,Erik Buskens,Marja A. Boermeester,Harry van Goor,Harro M. Timmerman,Vincent B. Nieuwenhuijs,Thomas L. Bollen,Bert van Ramshorst,Ben J.M. Witteman,Camiel Rosman,Rutger J. Ploeg,Menno A. Blink,Alexander F. Schaapherder,Cornelis H. C. Dejong,Peter J. Wahab,Ceesj H. M. Van Laarhoven,Erwin van der Harst,Casper H.J. van Eijck,Miguel A. Cuesta,Louis M. A. Akkermans,Hein G. Gooszen +23 more
TL;DR: In this article, the effects of probiotic prophylaxis in patients with predicted severe acute pancreatitis were evaluated in a multicentre randomised, double-blind, placebo-controlled trial.
Journal ArticleDOI
A conservative and minimally invasive approach to necrotizing pancreatitis improves outcome.
Hjalmar C. van Santvoort,Olaf J. Bakker,Thomas L. Bollen,Marc G. Besselink,Usama Ahmed Ali,A. Marjolein Schrijver,Marja A. Boermeester,Harry van Goor,Cornelis H. C. Dejong,Casper H.J. van Eijck,Bert van Ramshorst,Alexander F. Schaapherder,Erwin van der Harst,Sijbrand Hofker,Vincent B. Nieuwenhuijs,Menno A. Brink,Philip M Kruyt,Eric R. Manusama,George P. van der Schelling,Tom M. Karsten,Eric J. Hesselink,Cornelis J. H. M. van Laarhoven,Camiel Rosman,Koop Bosscha,Ralph J. de Wit,Alexander P. Houdijk,Miguel A. Cuesta,Peter J. Wahab,Hein G. Gooszen +28 more
TL;DR: Almost 62% of patients with necrotizing pancreatitis can be treated without an intervention and with low mortality, and in patients with infected necrosis, delayed intervention and catheter drainage as first treatment improves outcome.
Journal ArticleDOI
Endoscopic or surgical step-up approach for infected necrotising pancreatitis : A multicentre randomised trial
Sandra van Brunschot,Janneke van Grinsven,Hjalmar C. van Santvoort,Olaf J. Bakker,Marc G. Besselink,Marja A. Boermeester,Thomas L. Bollen,Koop Bosscha,Stefan A.W. Bouwense,Marco J. Bruno,Vincent C. Cappendijk,Esther C. J. Consten,Cornelis H. C. Dejong,Casper H.J. van Eijck,Willemien G. Erkelens,Harry van Goor,Wilhelmina M U van Grevenstein,Jan Willem Haveman,Sijbrand Hofker,Jeroen M. Jansen,Johan S. Laméris,Krijn P. van Lienden,Maarten Meijssen,Chris J. J. Mulder,Vincent B. Nieuwenhuijs,Jan-Werner Poley,Rutger Quispel,Rogier de Ridder,Tessa E H Römkens,Joris J. Scheepers,Nicolien J. Schepers,Matthijs P. Schwartz,Tom C.J. Seerden,B W Marcel Spanier,Jan Willem A Straathof,Marin Strijker,Robin Timmer,Niels G. Venneman,Frank P. Vleggaar,Rogier P. Voermans,Ben J.M. Witteman,Hein G. Gooszen,Marcel G. W. Dijkgraaf,Paul Fockens,Eric R. Manusama,Mohammed Hadithi,Camiel Rosman,Alexander F. Schaapherder,Erik J. Schoon +48 more
TL;DR: In patients with infected necrotising pancreatitis, the endoscopic step-up approach was not superior to the surgical step- up approach in reducing major complications or death, and the rate of pancreatic fistulas and length of hospital stay were lower in the endoscopy group.
Journal ArticleDOI
Autologous Bone Marrow-Derived Mesenchymal Stromal Cells for the Treatment of Allograft Rejection After Renal Transplantation: Results of a Phase I Study
Marlies E.J. Reinders,Johan W. de Fijter,Helene Roelofs,Ingeborg M. Bajema,Dorottya K. de Vries,Alexander F. Schaapherder,Frans H.J. Claas,Paula P.M.C. van Miert,Dave L. Roelen,Cees van Kooten,Willem E. Fibbe,Ton J. Rabelink +11 more
TL;DR: Autologous BM MSC treatment in transplant recipients with subclinical rejection and IF/TA is clinically feasible and safe, and the findings are suggestive of systemic immunosuppression.