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Alexander G. Bick
Researcher at Vanderbilt University Medical Center
Publications - 146
Citations - 9050
Alexander G. Bick is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 30, co-authored 87 publications receiving 5363 citations. Previous affiliations of Alexander G. Bick include Brigham and Women's Hospital & University of California, San Francisco.
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Journal ArticleDOI
Clonal Hematopoiesis and risk of atherosclerotic cardiovascular disease
Siddhartha Jaiswal,Pradeep Natarajan,Pradeep Natarajan,Alexander J. Silver,Christopher J. Gibson,Alexander G. Bick,Eugenia Shvartz,Marie McConkey,Namrata Gupta,Stacey Gabriel,Diego Ardissino,Usman Baber,Roxana Mehran,Valentin Fuster,Valentin Fuster,John Danesh,Philippe M. Frossard,Danish Saleheen,Olle Melander,Olle Melander,Galina K. Sukhova,Donna Neuberg,Peter Libby,Sekar Kathiresan,Benjamin L. Ebert +24 more
TL;DR: The presence of CHIP in peripheral‐blood cells was associated with nearly a doubling in the risk of coronary heart disease in humans and with accelerated atherosclerosis in mice.
Journal ArticleDOI
Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease
Amit Khera,Connor A. Emdin,Isabel Drake,Pradeep Natarajan,Alexander G. Bick,Nancy R. Cook,Daniel I. Chasman,Usman Baber,Roxana Mehran,Daniel J. Rader,Valentin Fuster,Eric Boerwinkle,Olle Melander,Marju Orho-Melander,Paul M. Ridker,Sekar Kathiresan +15 more
TL;DR: Among participants at high genetic risk, a favorable lifestyle was associated with a nearly 50% lower relative risk of coronary artery disease than was an unfavorable lifestyle, and across four studies involving 55,685 participants, genetic and lifestyle factors were independently associated with susceptibility to coronary arteries disease.
Journal ArticleDOI
Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia
Amit Khera,Amit Khera,Hong-Hee Won,Gina M. Peloso,Gina M. Peloso,Kim Lawson,Traci M. Bartz,Xuan Deng,Elisabeth M. van Leeuwen,Pradeep Natarajan,Pradeep Natarajan,Connor A. Emdin,Alexander G. Bick,Alanna C. Morrison,Jennifer A. Brody,Namrata Gupta,Akihiro Nomura,Akihiro Nomura,Thorsten Kessler,Stefano Duga,Joshua C. Bis,Cornelia M. van Duijn,L. Adrienne Cupples,Bruce M. Psaty,Daniel J. Rader,John Danesh,Heribert Schunkert,Ruth McPherson,Martin Farrall,Hugh Watkins,Eric S. Lander,James G. Wilson,Adolfo Correa,Eric Boerwinkle,Piera Angelica Merlini,Diego Ardissino,Danish Saleheen,Stacey Gabriel,Sekar Kathiresan,Sekar Kathiresan +39 more
TL;DR: In an analysis of participants with serial lipid measurements over many years, FH mutation carriers had higher cumulative exposure to LDL cholesterol than noncarriers and within any stratum of observed LDL cholesterol, risk of CAD was higher among FH mutations carriers than non carriers.
Journal ArticleDOI
Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood
Amit Khera,Mark Chaffin,Kaitlin H Wade,Sohail Zahid,Joseph Brancale,Rui Xia,Marina T. DiStefano,Ozlem Senol-Cosar,Ozlem Senol-Cosar,Ozlem Senol-Cosar,Mary E. Haas,Alexander G. Bick,Krishna G. Aragam,Eric S. Lander,George Davey Smith,Heather Mason-Suares,Heather Mason-Suares,Heather Mason-Suares,Myriam Fornage,Matthew S. Lebo,Matthew S. Lebo,Matthew S. Lebo,Nicholas J. Timpson,Lee M. Kaplan,Sekar Kathiresan +24 more
TL;DR: A new polygenic predictor comprised of 2.1 million common variants to quantify inherited susceptibility to obesity is derived and validated and test this predictor in more than 300,000 individuals ranging from middle age to birth.
Journal ArticleDOI
Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease
Angharad M. Roberts,Angharad M. Roberts,James S. Ware,Daniel S. Herman,Daniel S. Herman,Daniel S. Herman,Sebastian Schafer,John Baksi,Alexander G. Bick,Alexander G. Bick,Rachel Buchan,Roddy Walsh,Shibu John,S Wilkinson,Francesco Mazzarotto,Francesco Mazzarotto,Leanne E. Felkin,Leanne E. Felkin,Sungsam Gong,Jacqueline A. L. MacArthur,Fiona Cunningham,Jason Flannick,Jason Flannick,Stacey Gabriel,David Altshuler,David Altshuler,Peter S. Macdonald,Peter S. Macdonald,Peter S. Macdonald,Matthias Heinig,Anne Keogh,Anne Keogh,Anne Keogh,Christopher S. Hayward,Christopher S. Hayward,Christopher S. Hayward,Nicholas R. Banner,Nicholas R. Banner,Dudley J. Pennell,Dudley J. Pennell,Declan P. O'Regan,Tan Ru San,Antonio de Marvao,Timothy J W Dawes,Ankur Gulati,Emma J. Birks,Emma J. Birks,Magdi H. Yacoub,Michael H. Radke,Michael Gotthardt,James G. Wilson,Christopher J. O'Donnell,Sanjay K Prasad,Paul J.R. Barton,Paul J.R. Barton,Diane Fatkin,Diane Fatkin,Diane Fatkin,Norbert Hubner,Norbert Hubner,Jonathan G. Seidman,Christine E. Seidman,Stuart A. Cook +62 more
TL;DR: It is shown that TTNtv is the most common genetic cause of DCM in ambulant patients in the community, identify clinically important manifestations ofTTNtv-positive DCM, and define the penetrance and outcomes of TTNTV in the general population.