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Alexander G. Goglia
Researcher at Princeton University
Publications - 21
Citations - 984
Alexander G. Goglia is an academic researcher from Princeton University. The author has contributed to research in topics: Medicine & MAPK/ERK pathway. The author has an hindex of 9, co-authored 15 publications receiving 659 citations. Previous affiliations of Alexander G. Goglia include Columbia University & Rutgers University.
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Journal ArticleDOI
Androgen receptor signaling regulates DNA repair in prostate cancers
William R. Polkinghorn,Joel S. Parker,Man Xia Lee,Elizabeth M. Kass,Daniel E. Spratt,Phillip J. Iaquinta,Vivek K. Arora,Wei-Feng Yen,Ling Cai,Deyou Zheng,Brett S. Carver,Yu Chen,Philip A. Watson,Neel Shah,Sho Fujisawa,Alexander G. Goglia,Anuradha Gopalan,Haley Hieronymus,John Wongvipat,Peter T. Scardino,Michael J. Zelefsky,Maria Jasin,Jayanta Chaudhuri,Simon N. Powell,Charles L. Sawyers +24 more
TL;DR: It is demonstrated that the androgen receptor (AR) regulates a transcriptional program of DNA repair genes that promotes prostate cancer radioresistance, providing a potential mechanism by which androgen deprivation therapy synergizes with ionizing radiation.
Journal ArticleDOI
Four Key Steps Control Glycolytic Flux in Mammalian Cells.
Lukas B. Tanner,Alexander G. Goglia,Monica H. Wei,Talen Sehgal,Lance Parsons,Junyoung O. Park,Eileen White,Jared E. Toettcher,Joshua D. Rabinowitz +8 more
TL;DR: Flux control in glycolysis is concentrated in four key enzymatic steps, specifically upregulated by the Ras oncogene: optogenetic Ras activation rapidly induces the transcription of isozymes catalyzing these four steps and enhances gly colysis.
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Optogenetic control of protein binding using light-switchable nanobodies.
Agnieszka A. Gil,César Carrasco-López,Liyuan Zhu,Evan M. Zhao,Pavithran T. Ravindran,Maxwell Z. Wilson,Alexander G. Goglia,José L. Avalos,Jared E. Toettcher +8 more
TL;DR: The development of opto-nanobodies (OptoNBs), a versatile class of chimeric photoswitchable proteins whose binding to proteins of interest can be enhanced or inhibited upon blue light illumination, represents a step towards programmable photos witchable regulation of a wide variety of target proteins.
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Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells
TL;DR: It is reported that mutagenic NHEJ repair is suppressed in growth-arrested and serum-deprived cells, suggesting that end-joining activity in proliferating cells is more likely to be Mutagenic.
Journal ArticleDOI
A bright future: optogenetics to dissect the spatiotemporal control of cell behavior.
TL;DR: This work outlines how a new generation of optogenetic tools capable of directly controlling the activity of individual signaling nodes over time and the assembly of protein complexes in space are being used in conjunction with engineering-influenced experimental design to address longstanding questions in signaling biology.