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Alexander Grünberger

Researcher at Bielefeld University

Publications -  114
Citations -  2976

Alexander Grünberger is an academic researcher from Bielefeld University. The author has contributed to research in topics: Corynebacterium glutamicum & Population. The author has an hindex of 26, co-authored 99 publications receiving 2243 citations. Previous affiliations of Alexander Grünberger include Forschungszentrum Jülich & University of Delaware.

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Journal ArticleDOI

The development and application of a single-cell biosensor for the detection of l-methionine and branched-chain amino acids.

Nurije Mustafi, +4 more
- 01 Jul 2012 - 
TL;DR: A biosensor based on the transcriptional regulator Lrp that detects intracellular l-methionine and branched-chain amino acids in Corynebacterium glutamicum was developed and successfully used in a high-throughput (HT) FACS screen for the isolation of amino acid-producing mutants after random mutagenesis of a non-producing wild type strain.
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Single-cell microfluidics: opportunity for bioprocess development

Alexander Grünberger, +2 more
- 01 Oct 2014 - 
TL;DR: In well-defined perfusion experiments, central questions in biotechnology regarding, for example, growth, productivity, and heterogeneity on the single-cell level have been addressed for the first time and microfluidics will take its place as a single- cell analytical technique in biotechnological process and strain characterization.
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Construction of a Prophage-Free Variant of Corynebacterium glutamicum ATCC 13032 for Use as a Platform Strain for Basic Research and Industrial Biotechnology

Meike Baumgart, +8 more
- 01 Oct 2013 - 
TL;DR: The deletion of the prophages without any negative effect results in a novel platform strain for metabolic engineering and represents a useful step toward the construction of a C. glutamicum chassis genome of strain ATCC 13032 for biotechnological applications and synthetic biology.
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Taking control over control: use of product sensing in single cells to remove flux control at key enzymes in biosynthesis pathways.

Georg Schendzielorz, +9 more
- 17 Jan 2014 - 
TL;DR: In vivo screening of enzyme libraries by using metabolite sensors is extremely well suited to identify high-performance muteins required for overproduction, thus enabling ultrahigh-throughput screens by FACS.
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A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level.

Alexander Grünberger, +7 more
- 08 May 2012 - 
TL;DR: Design, fabrication and operation of a disposable picolitre cultivation system is described, in which environmental conditions can be well controlled on a short time scale and bacterial microcolony growth experiments can be observed by time-lapse microscopy.