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Alexander Hemprich
Researcher at Leipzig University
Publications - 126
Citations - 3690
Alexander Hemprich is an academic researcher from Leipzig University. The author has contributed to research in topics: Rhinoplasty & Distraction osteogenesis. The author has an hindex of 28, co-authored 126 publications receiving 3321 citations.
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Journal ArticleDOI
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24
Stefanie Birnbaum,Stefanie Birnbaum,Kerstin U. Ludwig,Heiko Reutter,Stefan Herms,Michael Steffens,Michele Rubini,Carlotta Baluardo,Melissa Ferrian,Nilma Almeida de Assis,Margrieta A. Alblas,Sandra Barth,Jan Freudenberg,Carola Lauster,Gül Schmidt,Martin Scheer,Bert Braumann,Stefaan J. Bergé,Rudolf H. Reich,Franziska Schiefke,Alexander Hemprich,Simone Pötzsch,Régine P.M. Steegers-Theunissen,Bernd Pötzsch,Susanne Moebus,Bernhard Horsthemke,Franz-Josef Kramer,Thomas F. Wienker,Peter A. Mossey,Peter Propping,Sven Cichon,Per Hoffmann,Michael Knapp,Markus M. Nöthen,Elisabeth Mangold +34 more
TL;DR: A 640-kb region at chromosome 8q24.21 was found to contain multiple markers with highly significant evidence for association with the cleft phenotype, including three markers that reached genome-wide significance.
Journal ArticleDOI
Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate
Elisabeth Mangold,Kerstin U. Ludwig,Stefanie Birnbaum,Carlotta Baluardo,Melissa Ferrian,Stefan Herms,Heiko Reutter,Nilma Almeida de Assis,Taofik Al Chawa,Manuel Mattheisen,Michael Steffens,Sandra Barth,Nadine Kluck,Anna Paul,Jessica Becker,Carola Lauster,Gül Schmidt,Bert Braumann,Martin Scheer,Rudolf H. Reich,Alexander Hemprich,Simone Pötzsch,Bettina Blaumeiser,Susanne Moebus,Michael Krawczak,Stefan Schreiber,Thomas Meitinger,Hans Erich Wichmann,Régine P.M. Steegers-Theunissen,Franz Josef Kramer,Sven Cichon,Peter Propping,Thomas F. Wienker,Michael Knapp,Michele Rubini,Peter A. Mossey,Per Hoffmann,Markus M. Nöthen +37 more
TL;DR: A genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an independent sample of 793 NSCL/ P triads is conducted.
Journal ArticleDOI
Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci
Kerstin U. Ludwig,Elisabeth Mangold,Stefan Herms,Stefanie Nowak,Stefanie Nowak,Heiko Reutter,Heiko Reutter,Anna Paul,Jessica Becker,Ruth Herberz,Taofik AlChawa,Entessar Nasser,Anne C. Böhmer,Manuel Mattheisen,Manuel Mattheisen,Margrieta A. Alblas,Sandra Barth,Nadine Kluck,Carola Lauster,Bert Braumann,Rudolf H. Reich,Alexander Hemprich,Simone Pötzsch,Bettina Blaumeiser,Nikolaos Daratsianos,Thomas Kreusch,Jeffrey C. Murray,Mary L. Marazita,Ingo Ruczinski,Alan F. Scott,Terri H. Beaty,Franz Josef Kramer,Thomas F. Wienker,Régine P.M. Steegers-Theunissen,Michele Rubini,Peter A. Mossey,Per Hoffmann,Christoph Lange,Christoph Lange,Sven Cichon,Peter Propping,Michael Knapp,Markus M. Nöthen +42 more
TL;DR: The first meta-analyses for nonsyndromic cleft lip with or without cleft palate (NSCL/P) using data from the two largest genome-wide association studies published to date identified the first specific genetic risk factor for NSCLP.
Journal ArticleDOI
The role of HPV RNA transcription, immune response-related gene expression and disruptive TP53 mutations in diagnostic and prognostic profiling of head and neck cancer.
Gunnar Wichmann,Maciej Rosolowski,Knut Krohn,Markus Kreuz,Andreas Boehm,Anett Reiche,Ulrike Scharrer,Dirk Halama,Julia Bertolini,Ulrike Bauer,Dana Holzinger,Michael Pawlita,Jochen Hess,Christoph Engel,Dirk Hasenclever,Markus Scholz,Peter Ahnert,Holger Kirsten,Alexander Hemprich,Christian Wittekind,Olf Herbarth,Friedemann Horn,Andreas Dietz,Markus Loeffler +23 more
TL;DR: It is found that tumors with transcriptionally inactive HPV16 (DNA+ RNA‐) are similar to HPV‐negative (DNA‐) tumors regarding gene expression and frequency of TP53 mutations and that an immune response‐related gene expression cluster is associated with lymph node metastasis, independent of HPV16 status.
Journal ArticleDOI
The role of surgical therapy in the management of intravenous bisphosphonates-related osteonecrosis of the jaw.
Frank Wilde,Marcus Heufelder,Karsten Winter,Jörg Hendricks,Bernhard Frerich,Alexander Schramm,Alexander Hemprich +6 more
TL;DR: It seems that patients with BRONJ may benefit from using a surgical concept characterized by resection of the necrotic bone followed by sufficient wound closure, because of the high success rate of this surgical technique.