A
Alexander L. Greninger
Researcher at University of Washington
Publications - 391
Citations - 16596
Alexander L. Greninger is an academic researcher from University of Washington. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 51, co-authored 298 publications receiving 11259 citations. Previous affiliations of Alexander L. Greninger include Seattle Children's & Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
Covid-19 in Critically Ill Patients in the Seattle Region - Case Series.
Pavan K. Bhatraju,Bijan J Ghassemieh,Michelle Nichols,Richard Kim,Keith R. Jerome,Arun K. Nalla,Alexander L. Greninger,Sudhakar Pipavath,Mark M Wurfel,Laura Evans,Patricia M Kritek,T. Eoin West,Andrew M Luks,Anthony Gerbino,Christopher R. Dale,Jason D Goldman,D. Shane O’Mahony,Carmen Mikacenic +17 more
TL;DR: During the first 3 weeks of the Covid-19 outbreak in the Seattle area, the most common reasons for admission to the ICU were hypoxemic respiratory failure leading to mechanical ventilation, hypotension requiring vasopressor treatment, or both.
Journal ArticleDOI
Performance Characteristics of the Abbott Architect SARS-CoV-2 IgG Assay and Seroprevalence in Boise, Idaho.
Andrew Bryan,Gregory Pepper,Mark H. Wener,Susan L. Fink,Chihiro Morishima,Anu Chaudhary,Keith R. Jerome,Keith R. Jerome,Patrick C. Mathias,Alexander L. Greninger,Alexander L. Greninger +10 more
TL;DR: It is expected that the availability of high-quality serological testing will be a key tool in the fight against SARS-CoV-2 as the limited circulation of the virus in the western United States.
Journal ArticleDOI
Neutralizing Antibodies Correlate with Protection from SARS-CoV-2 in Humans during a Fishery Vessel Outbreak with a High Attack Rate.
Amin Addetia,Katharine H.D. Crawford,Katharine H.D. Crawford,Adam S. Dingens,Haiying Zhu,Pavitra Roychoudhury,Pavitra Roychoudhury,Meei Li Huang,Meei Li Huang,Keith R. Jerome,Keith R. Jerome,Jesse D. Bloom,Jesse D. Bloom,Jesse D. Bloom,Alexander L. Greninger,Alexander L. Greninger +15 more
TL;DR: The development of vaccines against SARS-CoV-2 would be greatly facilitated by the identification of immunological correlates of protection in humans, as the presence of neutralizing antibodies from prior infection was significantly associated with protection against reinfection.
Journal ArticleDOI
Rapid metagenomic identification of viral pathogens in clinical samples by real-time nanopore sequencing analysis
Alexander L. Greninger,Samia N. Naccache,Scot Federman,Guixia Yu,Placide Mbala,Vanessa Brès,Doug Stryke,Jerome Bouquet,Sneha Somasekar,Jeffrey M. Linnen,Roger Y. Dodd,Prime Mulembakani,Bradley S. Schneider,Jean-Jacques Muyembe-Tamfum,Susan L. Stramer,Charles Y. Chiu +15 more
TL;DR: Using nanopore sequencing, metagenomic detection of viral pathogens directly from clinical samples was performed within an unprecedented <6 hr sample-to-answer turnaround time, and in a timeframe amenable to actionable clinical and public health diagnostics.
Journal ArticleDOI
Detection of SARS-CoV-2 with SHERLOCK One-Pot Testing.
Julia Joung,Alim Ladha,Makoto Saito,Nam-Gyun Kim,Ann E. Woolley,Michael Segel,Robert P.J. Barretto,Amardeep Ranu,Rhiannon K. Macrae,Guilhem Faure,Eleonora I. Ioannidi,Rohan N. Krajeski,Robert Bruneau,Meei Li W. Huang,Xu G. Yu,Jonathan Z. Li,Bruce D. Walker,Deborah T. Hung,Alexander L. Greninger,Keith R. Jerome,Jonathan S. Gootenberg,Omar O. Abudayyeh,Feng Zhang +22 more
TL;DR: A new method for the detection of SARS-CoV-2 combines simplified extraction of RNA with isothermal amplification and CRISPR (clustered regularly int…) with a CRISpr-Based Test.