Author
Alexander N. Glazer
Other affiliations: Pasteur Institute, University of California, Los Angeles, Lawrence Berkeley National Laboratory ...read more
Bio: Alexander N. Glazer is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Phycobilisome & Phycocyanin. The author has an hindex of 71, co-authored 208 publications receiving 21068 citations. Previous affiliations of Alexander N. Glazer include Pasteur Institute & University of California, Los Angeles.
Papers published on a yearly basis
Papers
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TL;DR: After separation by agarose gel electrophoresis, bands of precomplexed dsDNA-dye restriction fragments containing 10 pg of ds DNA are readily detected with a laser-excited confocal-fluorescence gel scanner and no significant dye migration in mixtures of prelabeled standard and unknown fragments.
30 citations
TL;DR: The determination of the mode of linkage of each of the three bilins on C-phycocyanin; two are linked through ring A and one through ring D is the first documented report of a singly D-ring-linked bilin.
29 citations
01 Jan 1979
TL;DR: It is here suggested that the various pigments involved were originally called into existence in response to certain physical environmental forces or variables and that by far the most important of these external factors was illumination.
Abstract: Everyone who has observed and considered a field of marine algae on the seashore at low tide knows that there are four very conspicuous groups of plants in the ocean. They are the blue-green, red, brown, and green algae. The obvious question is, Why does the sea contain plants of such a variety of colors when the land supports only green vegetation?… It is here suggested that the various pigments involved were originally called into existence in response to certain physical environmental forces or variables and that by far the most important of these external factors was illumination, the quantity or quality of which was determined or modified by two different media, (a) the sea water in which the organisms lived and (b) the layer of atmosphere above it.
28 citations
TL;DR: The auramine O-alcohol dehydrogenase interaction offers an additional case to the general correlation that most dyes which bind tightly to enzymes interact at regions overlapping binding sites for the normal ligands.
27 citations
TL;DR: A bilin-containing fragment of the beta subunit of Porphyridium cruentum B-phycoerythrin produced by cleavage with thermolysin was shown by sequence analysis to have the following structure.
27 citations
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TL;DR: The results of an international collaboration to produce and make freely available a draft sequence of the human genome are reported and an initial analysis is presented, describing some of the insights that can be gleaned from the sequence.
Abstract: The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence.
22,269 citations
28 Jul 2005
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。
18,940 citations
01 Jan 1969
10,262 citations
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Abstract: Semiconductor nanocrystals were prepared for use as fluorescent probes in biological staining and diagnostics. Compared with conventional fluorophores, the nanocrystals have a narrow, tunable, symmetric emission spectrum and are photochemically stable. The advantages of the broad, continuous excitation spectrum were demonstrated in a dual-emission, single-excitation labeling experiment on mouse fibroblasts. These nanocrystal probes are thus complementary and in some cases may be superior to existing fluorophores.
8,542 citations
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Abstract: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection. In comparison with organic dyes such as rhodamine, this class of luminescent labels is 20 times as bright, 100 times as stable against photobleaching, and one-third as wide in spectral linewidth. These nanometer-sized conjugates are water-soluble and biocompatible. Quantum dots that were labeled with the protein transferrin underwent receptor-mediated endocytosis in cultured HeLa cells, and those dots that were labeled with immunomolecules recognized specific antibodies or antigens.
7,393 citations