A
Alexander Tarakhovsky
Researcher at Rockefeller University
Publications - 88
Citations - 16217
Alexander Tarakhovsky is an academic researcher from Rockefeller University. The author has contributed to research in topics: Regulation of gene expression & Cellular differentiation. The author has an hindex of 55, co-authored 86 publications receiving 14871 citations. Previous affiliations of Alexander Tarakhovsky include University of Cologne.
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Journal ArticleDOI
Suppression of inflammation by a synthetic histone mimic
Edwige Nicodeme,Kate L. Jeffrey,Uwe Schaefer,Soren Beinke,Scott Dewell,Chun-wa Chung,Rohit Chandwani,Ivan Marazzi,Paul A. Wilson,Hervé Coste,Julia H. White,Jorge Kirilovsky,Charles M. Rice,Jose M. Lora,Rab K. Prinjha,Kevin Lee,Alexander Tarakhovsky +16 more
TL;DR: A synthetic compound (I-BET) is described that by ‘mimicking’ acetylated histones disrupts chromatin complexes responsible for the expression of key inflammatory genes in activated macrophages, and confers protection against lipopolysaccharide-induced endotoxic shock and bacteria-induced sepsis.
Journal ArticleDOI
Blimp1 is a critical determinant of the germ cell lineage in mice
Yasuhide Ohinata,Bernhard Payer,Dónal O'Carroll,Katia Ancelin,Yukiko Ono,Mitsue Sano,Sheila C. Barton,Tetyana V. Obukhanych,Michel C. Nussenzweig,Alexander Tarakhovsky,Mitinori Saitou,M. Azim Surani +11 more
TL;DR: It is shown that Blimp1 (also known as Prdm1), a known transcriptional repressor, has a critical role in the foundation of the mouse germ cell lineage, as its disruption causes a block early in the process of primordial germ cell formation.
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Essential Role of the Histone Methyltransferase G9a in Cocaine-induced Plasticity
Ian Maze,Herbert E. Covington,David M. Dietz,Quincey LaPlant,Quincey LaPlant,William Renthal,Scott J. Russo,Max Mechanic,Ezekiell Mouzon,Rachael L. Neve,Stephen J. Haggarty,Stephen J. Haggarty,Yanhua Ren,Srihari C. Sampath,Yasmin L. Hurd,Paul Greengard,Alexander Tarakhovsky,Anne Schaefer,Eric J. Nestler +18 more
TL;DR: Using conditional mutagenesis and viral-mediated gene transfer, it is found that G9a down-regulation increased the dendritic spine plasticity of nucleus accumbens neurons and enhanced the preference for cocaine, thereby establishing a crucial role for histone methylation in the long-term actions of cocaine.
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Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement
I-hsin Su,Ashwin Basavaraj,Andrew N. Krutchinsky,Oliver Hobert,Axel Ullrich,Brian T. Chait,Alexander Tarakhovsky +6 more
TL;DR: Ezh2-dependent histone H3 methylation as a novel regulatory mechanism controlling Igh rearrangement during early murine B cell development and rearrangements of the immunoglobulin heavy chain gene (Igh) are suggested.
Journal ArticleDOI
Maternal microRNAs are essential for mouse zygotic development
Fuchou Tang,Masahiro Kaneda,Dónal O'Carroll,Petra Hajkova,Sheila C. Barton,Y. Andrew Sun,Caroline Lee,Alexander Tarakhovsky,Kaiqin Lao,M. Azim Surani +9 more
TL;DR: The effects of the loss of maternal inheritance of miRNAs following specific deletion of Dicer from growing oocytes are shown, which demonstrates that the maternal mi RNAs are essential for the earliest stages of mouse embryonic development.