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Alexander Tomasz
Researcher at Rockefeller University
Publications - 291
Citations - 36341
Alexander Tomasz is an academic researcher from Rockefeller University. The author has contributed to research in topics: Streptococcus pneumoniae & Penicillin. The author has an hindex of 86, co-authored 289 publications receiving 35048 citations. Previous affiliations of Alexander Tomasz include University Hospital of Lausanne.
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Journal ArticleDOI
Genome sequencing in microfabricated high-density picolitre reactors
Marcel Margulies,Michael Egholm,William E. Altman,Said Attiya,Joel S. Bader,Lisa A. Bemben,Jan Berka,Michael S. Braverman,Yi-Ju Chen,Zhoutao Chen,Scott Dewell,Lei Du,J. M. Fierro,Xavier V. Gomes,Brian C. Godwin,Wen He,Scott Edward Helgesen,Chun Heen Ho,Gerard P. Irzyk,Szilveszter C. Jando,Maria L. I. Alenquer,Thomas P. Jarvie,Kshama B. Jirage,Jong-Bum Kim,James R. Knight,Janna R. Lanza,John H. Leamon,Steven Lefkowitz,Ming Lei,Jing Li,Kenton Lohman,Hong Lu,Vinod Makhijani,Keith Mcdade,Michael P. McKenna,Eugene W. Myers,Elizabeth Nickerson,John Nobile,Ramona Plant,Bernard P. Puc,Michael T. Ronan,George T. Roth,Gary J. Sarkis,Jan Fredrik Simons,John Simpson,Maithreyan Srinivasan,Karrie R. Tartaro,Alexander Tomasz,Kari A. Vogt,Greg A. Volkmer,Shally H. Wang,Yong Wang,Michael P. Weiner,Pengguang Yu,Richard F. Begley,Jonathan M. Rothberg +55 more
TL;DR: A scalable, highly parallel sequencing system with raw throughput significantly greater than that of state-of-the-art capillary electrophoresis instruments with 96% coverage at 99.96% accuracy in one run of the machine is described.
Journal ArticleDOI
Tackling antibiotic resistance
Karen Bush,Patrice Courvalin,Gautam Dantas,Julian Davies,Barry I. Eisenstein,Pentti Huovinen,George A. Jacoby,Roy Kishony,Barry N. Kreiswirth,Elizabeth Kutter,Stephen A. Lerner,Stuart B. Levy,Kim Lewis,Olga Lomovskaya,Jeffrey H Miller,Shahriar Mobashery,Laura J. V. Piddock,Steven J. Projan,Christopher M. Thomas,Alexander Tomasz,Paul M. Tulkens,Timothy R. Walsh,James D. Watson,Jan A. Witkowski,Wolfgang Witte,Gerry Wright,Pamela J. Yeh,Helen I. Zgurskaya +27 more
TL;DR: To explore how the problem of antibiotic resistance might best be addressed, a group of 30 scientists from academia and industry gathered at the Banbury Conference Centre in Cold Spring Harbor, New York, USA, from 16 to 18 May 2011.
Journal ArticleDOI
Rapid Pneumococcal Evolution in Response to Clinical Interventions
Nicholas J. Croucher,Simon R. Harris,Christophe Fraser,Michael A. Quail,John Burton,Mark van der Linden,Lesley McGee,Anne von Gottberg,Jae-Hoon Song,Kwan Soo Ko,Bruno Pichon,Stephen Baker,Christopher M. Parry,Lotte Lambertsen,Dea Shahinas,Dylan R. Pillai,Timothy J. Mitchell,Gordon Dougan,Alexander Tomasz,Keith P. Klugman,Keith P. Klugman,Keith P. Klugman,Julian Parkhill,William P. Hanage,William P. Hanage,Stephen D. Bentley +25 more
TL;DR: How genomic plasticity within lineages of recombinogenic bacteria can permit adaptation to clinical interventions over remarkably short time scales is detailed.
Journal ArticleDOI
Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus.
TL;DR: A high-molecular-weight PBP (PBP-2a; approximate size, 78,000 daltons) was detected that was only present in the resistant bacteria but not in the isogenic sensitive strain, and in cultures grown at pH 5.2, the extra PBP was not detectable.
Journal ArticleDOI
CD14 is a pattern recognition receptor.
Jérôme Pugin,I D Heumann,Alexander Tomasz,Vladimir V. Kravchenko,Y Akamatsu,M Nishijima,M. P. Glauser,Peter S. Tobias,Richard J. Ulevitch +8 more
TL;DR: It is proposed that CD14 is a receptor used by mammalian cells to recognize and signal responses to a diverse array of bacterial constituents, which defines the molecular basis for innate microbial immunity.