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Alexandra Abramsson
Researcher at University of Gothenburg
Publications - 32
Citations - 9765
Alexandra Abramsson is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Zebrafish & Pericyte. The author has an hindex of 17, co-authored 32 publications receiving 9028 citations. Previous affiliations of Alexandra Abramsson include Karolinska Institutet & University of Washington.
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Journal ArticleDOI
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Holger Gerhardt,Matthew Golding,Marcus Fruttiger,Christiana Ruhrberg,Andrea Lundkvist,Alexandra Abramsson,Michael Jeltsch,Christopher A. Mitchell,Kari Alitalo,David T. Shima,Christer Betsholtz +10 more
TL;DR: It is shown here that VEGF-A controls angiogenic sprouting in the early postnatal retina by guiding filopodial extension from specialized endothelial cells situated at the tips of the vascular sprouts.
Journal ArticleDOI
Endothelial/Pericyte Interactions
TL;DR: This review focuses on the advancement in recent years of the understanding of intercellular communication between endothelial and mural cells with a focus on transforming growth factor α, angiopoietins, platelet-derived growth factor, spingosine-1-phosphate, and Notch ligands and their respective receptors.
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Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse.
TL;DR: This work used desmin and alpha-smooth muscle actin (ASMA) as markers to analyze vSMC/PC development in PDGF-B-/- and PDGFR-beta-/- embryos and found that endothelial expression of PDGF -B was restricted to immature capillary endothelial cells and to the endothelium of growing arteries.
Journal ArticleDOI
Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall.
Per Lindblom,Holger Gerhardt,Stefan Liebner,Alexandra Abramsson,Maria Enge,Mats Hellström,Gudrun Bäckström,Simon Fredriksson,Ulf Landegren,Henrik C. Nyström,Göran Bergström,Elisabetta Dejana,Arne Östman,Per Lindahl,Christer Betsholtz +14 more
TL;DR: It is concluded that retention of PDGF-B in microvessels is essential for proper recruitment and organization of pericytes and for renal and retinal function in adult mice.
Journal ArticleDOI
PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.
Xuri Li,Annica Pontén,Karin Aase,L. Karlsson,Alexandra Abramsson,Marko Uutela,Gudrun Bäckström,Mats Hellström,Hans Boström,Hong Li,Philippe Soriano,Christer Betsholtz,Carl-Henrik Heldin,Kari Alitalo,Arne Östman,Ulf Eriksson +15 more
TL;DR: A new PDGF, PDGF-C, is identified, which binds to and activates the PDGF α-receptor and is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice.