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Alexandre Arcaro

Researcher at University of Bern

Publications -  80
Citations -  10812

Alexandre Arcaro is an academic researcher from University of Bern. The author has contributed to research in topics: PI3K/AKT/mTOR pathway & Protein kinase B. The author has an hindex of 41, co-authored 79 publications receiving 10100 citations. Previous affiliations of Alexandre Arcaro include National Institutes of Health & Imperial College London.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

Alexandre Arcaro, +1 more
- 01 Dec 1993 - 
TL;DR: Evidence is presented that wortmannin, a known inhibitor of respiratory-burst activity, acts on PtdIns 3-kinase, the enzyme producing PTDInsP3 from Ptd Ins(4,5)P2, which implies that PtdinsP3 production is not a primary event triggering elongation of actin filaments in neutrophils.
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CD8beta endows CD8 with efficient coreceptor function by coupling T cell receptor/CD3 to raft-associated CD8/p56(lck) complexes.

Alexandre Arcaro, +10 more
- 19 Nov 2001 - 
TL;DR: It is reported that cell-associated CD8αβ, but not CD8 αα or soluble CD8β, substantially increases the avidity of T cell receptor (TCR)-ligand binding.
Journal ArticleDOI

The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications

Alexandre Arcaro, +1 more
- 31 Jul 2007 - 
TL;DR: The evidence implicating individual PI3K isoforms in human cancer and their potential as drug targets in this context are discussed.
Journal ArticleDOI

Essential role of CD8 palmitoylation in CD8 coreceptor function.

Alexandre Arcaro, +6 more
- 15 Aug 2000 - 
TL;DR: This study shows that palmitoylation of CD8β is required for efficient CD8 coreceptor function, mainly because it dramatically increases CD8 association with p56lck and CD8-mediated activation of p56 lck in lipid rafts.