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Alexey V. Pshezhetsky
Researcher at Université de Montréal
Publications - 132
Citations - 8562
Alexey V. Pshezhetsky is an academic researcher from Université de Montréal. The author has contributed to research in topics: Neuraminidase & Cathepsin A. The author has an hindex of 44, co-authored 123 publications receiving 7778 citations. Previous affiliations of Alexey V. Pshezhetsky include Oklahoma State University–Stillwater & Moscow State University.
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Journal ArticleDOI
A genome-wide association study identifies novel risk loci for type 2 diabetes
Robert Sladek,Ghislain Rocheleau,Johan Rung,Christian Dina,Lishuang Shen,David Serre,Philippe Boutin,Daniel Vincent,Alexandre Belisle,Samy Hadjadj,Beverley Balkau,Barbara Heude,Guillaume Charpentier,Thomas J. Hudson,Thomas J. Hudson,Alexandre Montpetit,Alexey V. Pshezhetsky,Marc Prentki,Barry I. Posner,David J. Balding,David Meyre,Constantin Polychronakos,Philippe Froguel,Philippe Froguel +23 more
TL;DR: Four loci containing variants that confer type 2 diabetes risk are identified and constitute proof of principle for the genome-wide approach to the elucidation of complex genetic traits.
Journal ArticleDOI
De Novo Mutations in Moderate or Severe Intellectual Disability
Fadi F. Hamdan,Myriam Srour,Jose-Mario Capo-Chichi,Hussein Daoud,Christina Nassif,Lysanne Patry,Christine Massicotte,Amirthagowri Ambalavanan,Dan Spiegelman,Ousmane Diallo,Edouard Henrion,Alexandre Dionne-Laporte,Anne Fougerat,Alexey V. Pshezhetsky,Sunita Venkateswaran,Guy A. Rouleau,Jacques L. Michaud +16 more
TL;DR: It is concluded that DNMs represent a major cause of moderate or severe ID.
Journal ArticleDOI
Cloning, expression and chromosomal mapping of human lysosomal sialidase and characterization of mutations in sialidosis.
Alexey V. Pshezhetsky,Catherine Richard,Lorraine Michaud,Suleiman A. Igdoura,Shupei Wang,Marc-André Elsliger,Jingyi Qu,Daniel Leclerc,Roy A. Gravel,Louis Dallaire,Michel Potier +10 more
TL;DR: The lysosomal sialidase gene is mapped to human chromosome 6 (6p21.3), which is consistent with the previous chromosomal assignment of this gene in proximity to the HLA locus, and its cloning, sequencing and expression are reported.
Journal ArticleDOI
Neu1 desialylation of sialyl α-2,3-linked β-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling.
Schammim Ray Amith,Preethi Jayanth,Susan Franchuk,Trisha Finlay,Volkan Seyrantepe,Rudi Beyaert,Alexey V. Pshezhetsky,Myron R. Szewczuk +7 more
TL;DR: The findings suggest that Neu1 desialylation of alpha-2,3-sialyl residues of TLR receptors enables in removing a steric hinderance to receptor association for TLR activation and cellular signaling.
Journal ArticleDOI
Lysosomal sialidase (neuraminidase-1) is targeted to the cell surface in a multiprotein complex that facilitates elastic fiber assembly.
TL;DR: Hinek et al. as mentioned in this paper showed that the 67-kDa elastin-binding protein (EBP) also forms a cell surface-targeted molecular complex with protective protein/cathepsin A and sialidase (neuraminidase-1).