Alfonso De Stefano

TL;DR: The scoring system obtained with a regression model on the basis of follow-up data is useful for defining subgroups of patients at a very low or very high risk of tumor recurrence after radical surgery for gastric cancer.

TL;DR: The combined assay of CEA, CA 19-9 and CA 72-4 preoperative serum levels provides additional prognostic information in patients resected for gastric cancer; patients with preoperative positivity for one of these tumor markers should be considered at high risk of recurrence even in early stages of gastric carcinoma.

TL;DR: A set of 13 miRNAs is strongly associated with pCR and may represent a specific predictor of response to chemoradiotherapy in rectal cancer patients.

TL;DR: SphK1 contribution to resistance was supported by the demonstration that SphK 1 inhibition by N,N-dimethyl-sphingosine or silencing via siRNA in resistant cells restores sensitivity to cetuximab, whereas exogenous SphK1 overexpression in sensitive cells confers resistance to these agents.

TL;DR: To address concerns that mutations detected on cytology are not representative of the entire tumor and are less reliable in predicting response to tyrosine kinase inhibitor (TKI) treatment, the authors reviewed their clinical practice archives and compared the outcome of TKI treatment among patients who were selected by cytology versus patients who are selected by histology.