Author
Ali A. Mohammadi
Other affiliations: Shahid Beheshti University, Persian Gulf University
Bio: Ali A. Mohammadi is an academic researcher from Islamic Azad University. The author has contributed to research in topics: One-pot synthesis & Ninhydrin. The author has an hindex of 19, co-authored 75 publications receiving 1420 citations. Previous affiliations of Ali A. Mohammadi include Shahid Beheshti University & Persian Gulf University.
Topics: One-pot synthesis, Ninhydrin, Isatin, Catalysis, Condensation reaction
Papers
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TL;DR: KAl(SO4)2·12H2O was found to catalyze efficiently a one-pot three-component cyclocondensation of isatoic anhydride and primary amines or ammonia sources such as NH4 2CO3, NH4OAc and NH4Cl with aromatic aldehydes under mild conditions to afford the corresponding mono- and disubstituted 2,3-dihydroquinazolin-4(1H)-ones in good yields as mentioned in this paper.
181 citations
TL;DR: In this paper, an efficient synthesis of various tetrasubstituted imidazoles using silica gel-supported sodium bisulfate as a catalytic support by four-component condensation of benzil or benzoin, aldehydes, amines, and ammonium acetate under microwave irradiation or classical heating conditions is described.
141 citations
TL;DR: 12H(2)O is found to catalyze efficiently the stereoselective one-pot three-component cyclocondensation of homophthalic anhydride, aldehydes, and amines under mild conditions to afford the corresponding cis-isoquinolonic acids in good yields.
Abstract: KAl(SO(4))(2).12H(2)O is found to catalyze efficiently the stereoselective one-pot three-component cyclocondensation of homophthalic anhydride, aldehydes, and amines under mild conditions to afford the corresponding cis-isoquinolonic acids in good yields.
90 citations
TL;DR: In this article, 3,4-Dihydropyrimidin-2(1H)-ones derivatives were synthesized in moderate to high yields in one-pot three component reaction from the corresponding aldehydes, ketones or 1,3-dicarbonyl compounds and urea.
Abstract: 3,4-Dihydropyrimidin-2(1H)-ones derivatives were synthesized in moderate to high yields in one-pot three component reaction from the corresponding aldehydes, ketones or 1,3-dicarbonyl compounds and urea, in the presence of catalytic amount of KAl(SO4)2·12H2O (Alum) supported on silica gel (Alum-SiO2) as a non-toxic, reusable, inexpensive and easily available reagent, under solvent-free conditions at 80 °C. Compared to the classical Biginelli reaction, this new method consistently has the advantage of good yields.
90 citations
TL;DR: In this article, a multi-component condensation of resorcinol, malononitrile, and various aldehydes in propanol in an undivided cell in the presence of NaBr as an electrolyte results in the formation of 2amino-4H-chromenes in good yields and short reaction time.
83 citations
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1,273 citations
TL;DR: This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, as to provide real-time information about the response of the immune system to EMTs.
Abstract: Department of Natural Products for Chemical Genetic Research, Key Laboratory of Brain Functional Genomics, Ministry of Education & Shanghai Key Laboratory of Brain Functional Genomics (MOE & SBFG), East China Normal University, Shanghai, 200062, China and Department of Pharmacognosy and National Center for Natural Products Research (NCNPR), School of Pharmacy, The University of Mississippi, Oxford, Mississippi 38677
863 citations
TL;DR: A concise account of the isolation, bioactivity, and synthesis of bioactive quinazolinone-based natural products for the period 1983-2005 is given in this paper.
607 citations
TL;DR: In this paper, the authors summarized the results reported mainly within the last 10 years, and it is quite clear from the growing number of emerging publications in this field that the possibility to utilize multicomponent technology allows reaction conditions to be accessed that are very valuable for organic synthesis.
Abstract: Multicomponent reactions have gained significant importance as a tool for the synthesis of a wide variety of useful compounds, including pharmaceuticals. In this context, the multiple component approach is especially appealing in view of the fact that products are formed in a single step, and the diversity can be readily achieved simply by varying the reacting components. The eco-friendly, solvent-free multicomponent approach opens up numerous possibilities for conducting rapid organic synthesis and functional group transformations more efficiently. Additionally, there are distinct advantages of these solvent-free protocols since they provide reduction or elimination of solvents thereby preventing pollution in organic synthesis “at source”. The chemo-, regio- or stereoselective synthesis of high-value chemical entities and parallel synthesis to generate a library of small molecules will add to the growth of multicomponent solvent-free reactions in the near future. In this review we summarized the results reported mainly within the last 10 years. It is quite clear from the growing number of emerging publications in this field that the possibility to utilize multicomponent technology allows reaction conditions to be accessed that are very valuable for organic synthesis. Therefore, diversity oriented synthesis (DOS) is rapidly becoming one of the paradigms in the process of modern drug discovery. This has spurred research in those fields of chemical investigation that lead to the rapid assembly of not only molecular diversity, but also molecular complexity. As a consequence multi-component as well as domino or related reactions are witnessing a new spring.
420 citations