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Alice Kaganovich
Researcher at National Institutes of Health
Publications - 33
Citations - 6466
Alice Kaganovich is an academic researcher from National Institutes of Health. The author has contributed to research in topics: LRRK2 & Kinase activity. The author has an hindex of 16, co-authored 28 publications receiving 5529 citations. Previous affiliations of Alice Kaganovich include University of Padua.
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Journal ArticleDOI
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD
Alan E. Renton,Elisa Majounie,Adrian James Waite,Javier Simón-Sánchez,Javier Simón-Sánchez,Sara Rollinson,J. Raphael Gibbs,J. Raphael Gibbs,Jennifer C. Schymick,Hannu Laaksovirta,John C. van Swieten,John C. van Swieten,Liisa Myllykangas,Hannu Kalimo,Anders Paetau,Yevgeniya Abramzon,Anne M. Remes,Alice Kaganovich,Sonja W. Scholz,Sonja W. Scholz,Sonja W. Scholz,Jamie Duckworth,Jinhui Ding,Daniel W. Harmer,Dena G. Hernandez,Dena G. Hernandez,Janel O. Johnson,Janel O. Johnson,Kin Y. Mok,Mina Ryten,Danyah Trabzuni,Rita Guerreiro,Richard W. Orrell,James Neal,Alexandra Murray,J. P. Pearson,Iris E. Jansen,David Sondervan,Harro Seelaar,Derek J. Blake,Kate Young,Nicola Halliwell,Janis Bennion Callister,Greg Toulson,Anna Richardson,Alexander Gerhard,Julie S. Snowden,David M. A. Mann,David Neary,Mike A. Nalls,Terhi Peuralinna,Lilja Jansson,Veli-Matti Isoviita,Anna-Lotta Kaivorinne,Maarit Hölttä-Vuori,Elina Ikonen,Raimo Sulkava,Michael Benatar,Joanne Wuu,Adriano Chiò,Gabriella Restagno,Giuseppe Borghero,Mario Sabatelli,David Heckerman,Ekaterina Rogaeva,Lorne Zinman,Jeffrey D. Rothstein,Michael Sendtner,Carsten Drepper,Evan E. Eichler,Can Alkan,Ziedulla Abdullaev,Svetlana Pack,Amalia Dutra,Evgenia Pak,John Hardy,Andrew B. Singleton,Nigel Williams,Peter Heutink,Stuart Pickering-Brown,Huw R. Morris,Huw R. Morris,Huw R. Morris,Pentti J. Tienari,Bryan J. Traynor,Bryan J. Traynor +85 more
TL;DR: The chromosome 9p21 amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) locus contains one of the last major unidentified autosomal-dominant genes underlying these common neurodegenerative diseases, and a large hexanucleotide repeat expansion in the first intron of C9ORF72 is shown.
Journal ArticleDOI
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin.
Elisa Greggio,Shushant Jain,Ann E. Kingsbury,Rina Bandopadhyay,Patrick A. Lewis,Alice Kaganovich,Marcel P. van der Brug,Alexandra Beilina,Jeff Blackinton,Kelly Jean Thomas,Rili Ahmad,David Miller,Sashi Kesavapany,Andrew B. Singleton,Andrew J. Lees,Robert J. Harvey,Kirsten Harvey,Mark R. Cookson +17 more
TL;DR: Manipulating activity by replacing the kinase domain with a 'kinase-dead' version blocks inclusion body formation and strongly delays cell death, predicting that kinase inhibitors will be useful therapeutic agents in patients with LRRK2 mutations and, perhaps, in sporadic PD.
Journal ArticleDOI
A soluble α-synuclein construct forms a dynamic tetramer
Wei Wang,Iva Perovic,Johnathan Chittuluru,Alice Kaganovich,Linh T.T. Nguyen,Linh T.T. Nguyen,Jingling Liao,Jingling Liao,Jared R. Auclair,Derrick E. Johnson,Derrick E. Johnson,Anuradha Landeru,Anuradha Landeru,Alana K. Simorellis,Shulin Ju,Mark R. Cookson,Francisco J. Asturias,Jeffrey N. Agar,Brian N. Webb,ChulHee Kang,Dagmar Ringe,Dagmar Ringe,Gregory A. Petsko,Gregory A. Petsko,Thomas C. Pochapsky,Quyen Q. Hoang +25 more
TL;DR: A dynamic model for the tetramer structure is proposed, based on expected close association of the amphipathic central helices observed in the previously described micelle-associated “hairpin” structure of α-synuclein, which indicates that a symmetric oligomer is present, with three- or fourfold symmetry.
Journal ArticleDOI
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
Alexandra Beilina,Iakov N. Rudenko,Alice Kaganovich,Laura Civiero,H. Chau,Suneil K. Kalia,Lorraine V. Kalia,Evy Lobbestael,Ruth Chia,Kelechi Ndukwe,J. Ding,Mike A. Nalls,Maciej B. Olszewski,David N. Hauser,Ravindran Kumaran,Andres M. Lozano,Veerle Baekelandt,Lois E. Greene,Jean-Marc Taymans,Elisa Greggio,M. R. Cookson,Vincent Plagnol,Maria Martinez,Dena G. Hernandez,Dena G. Hernandez,Manu Sharma,UM Sheerin,Mohamad Saad,Javier Simón-Sánchez,Claudia Schulte,Suzanne Lesage,Suzanne Lesage,Suzanne Lesage,S. Sveinbjornsdottir,S. Sveinbjornsdottir,Sampath Arepalli,Roger A. Barker,Yoav Ben-Shlomo,Henk W. Berendse,Daniela Berg,Kailash P. Bhatia,R. M. A. de Bie,Alessandra Biffi,Alessandra Biffi,B.R. Bloem,Zoltán Bochdanovits,Michael Bonin,Jose Bras,Kathrin Brockmann,Janet Brooks,David J. Burn,Gavin Charlesworth,Honglei Chen,Sean Chong,Carl E Clarke,J. M. Cooper,Jean-Christophe Corvol,Carl Counsell,P. Damier,J. F. Dartigues,Panagiotis Deloukas,Günther Deuschl,David T. Dexter,K.D. van Dijk,Allissa Dillman,F. Durif,Alexandra Durr,Sarah Edkins,Jonathan R. Evans,Thomas Foltynie,Jiali Gao,M. Gardner,J. R. Gibbs,J. R. Gibbs,A. Goate,Emma Gray,Rita Guerreiro,Omar Gustafsson,Omar Gustafsson,Clare Elizabeth Harris,J.J. van Hilten,Albert Hofman,Albert R. Hollenbeck,Janice L. Holton,Michele T.M. Hu,X. Huang,Heiko Huber,Gavin Hudson,Sarah E. Hunt,Johanna Huttenlocher,Thomas Illig,H. Z. Munchen,Palmi V. Jonsson,Jean-Charles Lambert,Jean-Charles Lambert,Cordelia Langford,Andrew J. Lees,Peter Lichtner,Patricia Limousin,Grisel Lopez,Delia Lorenz,Alisdair McNeill,C. Moorby,Matthew Moore,Huw R. Morris,Karen E. Morrison,Karen E. Morrison,Ese E. Mudanohwo,Sean S. O'Sullivan,James A. Pearson,Joel S. Perlmutter,H. Petursson,H. Petursson,Pierre Pollak,Bart Post,Simon C. Potter,Bernard Ravina,Tamas Revesz,Olaf Riess,Fernando Rivadeneira,Patrizia Rizzu,Mina Ryten,Stephen Sawcer,Anthony H.V. Schapira,Hans Scheffer,K. Shaw,Ira Shoulson,Ellen Sidransky,C Smith,Chris C. A. Spencer,Hreinn Stefansson,Stacy Steinberg,Joanne D. Stockton,A. Strange,Kevin Talbot,Caroline M. Tanner,Avazeh Tashakkori-Ghanbaria,François Tison,Daniah Trabzuni,Bryan J. Traynor,André G. Uitterlinden,Daan C. Velseboer,Marie Vidailhet,Marie Vidailhet,R. Walker,B.P.C. van de Warrenburg,M M Wickremaratchi,Nigel Williams,Caroline H. Williams-Gray,Sophie Winder-Rhodes,Kari Stefansson,John Hardy,Peter Heutink,Alexis Brice,T. Gasser,T. Gasser,Andrew B. Singleton,Nicholas W. Wood,Patrick F. Chinnery,Luigi Ferrucci,Robert L. Johnson,Dan L. Longo,Elisa Majounie,Richard O'Brien,Juan C. Troncoso,M. Van Der Brug,H. R. Zielke,H. R. Zielke,Alan B. Zonderman +168 more
TL;DR: It is shown, using the specific example of Parkinson disease, that identification of protein–protein interactions can help determine the most likely candidate for several GWAS loci, and proposed that three different genes for PD have a common biological function.
Journal ArticleDOI
The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation
Elisa Greggio,Ibardo Zambrano,Alice Kaganovich,Alexandra Beilina,Jean-Marc Taymans,Veronique Daniëls,Patrick A. Lewis,Shushant Jain,Jinhui Ding,Ali Syed,Kelly Jean Thomas,Veerle Baekelandt,Mark R. Cookson +12 more
TL;DR: It is shown that L RRK2 predominantly exists as a dimer under native conditions, a state that appears to be stabilized by multiple domain-domain interactions and it is demonstrated that LRRK2 undergoes intramolecular autophosphorylation.