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Alicia Viloria-Petit
Researcher at Ontario Veterinary College
Publications - 44
Citations - 4217
Alicia Viloria-Petit is an academic researcher from Ontario Veterinary College. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor A. The author has an hindex of 21, co-authored 40 publications receiving 3793 citations. Previous affiliations of Alicia Viloria-Petit include Women's College, Kolkata & Sunnybrook Health Sciences Centre.
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Journal ArticleDOI
Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration
Valbona Luga,Liang Zhang,Alicia Viloria-Petit,Abiodun A. Ogunjimi,Mohammad R. Inanlou,Elaine Chiu,Marguerite Buchanan,Abdel Nasser Hosein,Mark Basik,Jeffrey L. Wrana,Jeffrey L. Wrana +10 more
TL;DR: It is reported that fibroblast-secreted exosomes promote breast cancer cell (BCC) protrusive activity and motility via Wnt-planar cell polarity (PCP) signaling and it is demonstrated that exosome-stimulated BCC protrusions display mutually exclusive localization of the core PCP complexes.
Journal Article
Acquired Resistance to the Antitumor Effect of Epidermal Growth Factor Receptor-blocking Antibodies in Vivo A Role for Altered Tumor Angiogenesis
Alicia Viloria-Petit,Tania Crombet,Serge Jothy,Daniel J. Hicklin,Peter Bohlen,Jean Marc Schlaeppi,Janusz Rak,Robert S. Kerbel +7 more
TL;DR: The results suggest that variants displaying acquired resistance to anti-EGFR antibodies can emerge in vivo and can do so, at least in part, by mechanisms involving the selection of tumor cell subpopulations with increased angiogenic potential.
Journal Article
Oncogenes and Tumor Angiogenesis: Differential Modes of Vascular Endothelial Growth Factor Up-Regulation in ras-transformed Epithelial Cells and Fibroblasts
Janusz Rak,Yoshihiro Mitsuhashi,Cap Sheehan,Ami Tamir,Alicia Viloria-Petit,Jorge Filmus,Sam J. Mansour,Natalie G. Ahn,Robert S. Kerbel +8 more
TL;DR: The data suggest that the stimulatory effect of mutant ras on VEGF expression is executed in a nonautocrine and cell type-dependent manner and that it can be significantly exacerbated by physiological/ environmental influences such as high cell density.
Journal ArticleDOI
Possible mechanisms of acquired resistance to anti-angiogenic drugs: implications for the use of combination therapy approaches.
Robert S. Kerbel,Joanne Yu,Jennifer A. Tran,Shan Man,Alicia Viloria-Petit,Giannoula Klement,Brenda L. Coomber,Janusz Rak +7 more
TL;DR: The ultimate target of anti-angiogenic drugs is the genetically stable, activated endothelial cell of a newly forming tumor blood vessel, rather than the genetically unstable tumor cell population per se, which led to the notion that acquired resistance to such drugs may not develop as readily.
Journal ArticleDOI
Oncogenes and tumor angiogenesis: the HPV-16 E6 oncoprotein activates the vascular endothelial growth factor (VEGF) gene promoter in a p53 independent manner.
Omar López-Ocejo,Alicia Viloria-Petit,Mónica Bequet-Romero,Debabrata Mukhopadhyay,Janusz Rak,Robert S. Kerbel,Robert S. Kerbel +6 more
TL;DR: The results suggest the possibility that the HPV oncoprotein E6 may contribute to tumor angiogenesis by direct stimulation of the VEGF gene.