Alisha V. Ling

TL;DR: Increases in the abundance and activity of Bilophila wadsworthia on the animal-based diet support a link between dietary fat, bile acids and the outgrowth of microorganisms capable of triggering inflammatory bowel disease.

TL;DR: In this article, the authors identify the enzyme flavin-containing monooxygenase 3 (Fmo3) to be a target of insulin and show that FMO3 is suppressed by insulin in vitro, increased in obese/insulin resistant male mice and increased in overweight/inulin resistant humans.

TL;DR: Data indicate that although insulin induces PCSK9 expression, it is not the sole or even dominant regulator ofPCSK9 under all conditions.

TL;DR: The pervasive role of FoxO1 in mediating the effects of insulin on not only glucose metabolism but also other hormonal signaling pathways and even some aspects of lipid metabolism is revealed.

TL;DR: Insulin, by inhibiting FoxO1 in the liver, reduces 12α-hydroxylated bile acids, cholesterol absorption, and plasma cholesterol levels, which suggest that a personalized approach to lipid lowering in type 1 diabetes may be more effective and highlight the need for further studies specifically in this group of patients.