A
Alison M. Dunning
Researcher at University of Cambridge
Publications - 473
Citations - 45416
Alison M. Dunning is an academic researcher from University of Cambridge. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 99, co-authored 437 publications receiving 39481 citations. Previous affiliations of Alison M. Dunning include Cambridge University Hospitals NHS Foundation Trust & Sheba Medical Center.
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Journal ArticleDOI
Genome-wide association study identifies novel breast cancer susceptibility loci
Douglas F. Easton,Karen A. Pooley,Alison M. Dunning,Paul D.P. Pharoah,Deborah J. Thompson,Dennis G. Ballinger,Jeffery P. Struewing,Jonathan J. Morrison,Helen I. Field,Robert Luben,Nicholas J. Wareham,Shahana Ahmed,Catherine S. Healey,Richard Bowman,Kerstin B. Meyer,Christopher A. Haiman,Laurence K. Kolonel,Brian E. Henderson,Loic Le Marchand,Paul Brennan,Suleeporn Sangrajrang,Valerie Gaborieau,Fabrice Odefrey,Chen-Yang Shen,Pei-Ei Wu,Hui-Chun Wang,Diana Eccles,D. Gareth Evans,Julian Peto,Olivia Fletcher,Nichola Johnson,Sheila Seal,Michael R. Stratton,Nazneen Rahman,Georgia Chenevix-Trench,Georgia Chenevix-Trench,Stig E. Bojesen,Børge G. Nordestgaard,C K Axelsson,Montserrat Garcia-Closas,Louise A. Brinton,Stephen J. Chanock,Jolanta Lissowska,Beata Peplonska,Heli Nevanlinna,Rainer Fagerholm,H Eerola,Daehee Kang,Keun-Young Yoo,Dong-Young Noh,Sei Hyun Ahn,David J. Hunter,Susan E. Hankinson,David G. Cox,Per Hall,Sara Wedrén,Jianjun Liu,Yen-Ling Low,Natalia Bogdanova,Peter Schu¨rmann,Do¨rk Do¨rk,Rob A. E. M. Tollenaar,Catharina E. Jacobi,Peter Devilee,Jan G. M. Klijn,Alice J. Sigurdson,Michele M. Doody,Bruce H. Alexander,Jinghui Zhang,Angela Cox,Ian W. Brock,Gordon MacPherson,Malcolm W.R. Reed,Fergus J. Couch,Ellen L. Goode,Janet E. Olson,Hanne Meijers-Heijboer,Hanne Meijers-Heijboer,Ans M.W. van den Ouweland,André G. Uitterlinden,Fernando Rivadeneira,Roger L. Milne,Gloria Ribas,Anna González-Neira,Javier Benitez,John L. Hopper,Margaret R. E. McCredie,Margaret R. E. McCredie,Margaret R. E. McCredie,Melissa C. Southey,Melissa C. Southey,Graham G. Giles,Chris Schroen,Christina Justenhoven,Christina Justenhoven,Hiltrud Brauch,Hiltrud Brauch,Ute Hamann,Yon-Dschun Ko,Amanda B. Spurdle,Jonathan Beesley,Xiaoqing Chen,_ kConFab,Arto Mannermaa,Veli-Matti Kosma,Vesa Kataja,Jaana M. Hartikainen,Nicholas E. Day,David Cox,Bruce A.J. Ponder +109 more
TL;DR: To identify further susceptibility alleles, a two-stage genome-wide association study in 4,398 breast cancer cases and 4,316 controls was conducted, followed by a third stage in which 30 single nucleotide polymorphisms were tested for confirmation.
Journal ArticleDOI
Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies
Fiona M. Blows,Kristy Driver,Marjanka K. Schmidt,Annegien Broeks,Flora E. van Leeuwen,Jelle Wesseling,Maggie C.U. Cheang,Karen A. Gelmon,Torsten O. Nielsen,Carl Blomqvist,Päivi Heikkilä,Tuomas Heikkinen,Heli Nevanlinna,Lars A. Akslen,Louis R. Bégin,William D. Foulkes,Fergus J. Couch,Xianshu Wang,Vicky Cafourek,Janet E. Olson,Laura Baglietto,Graham G. Giles,Gianluca Severi,Catriona McLean,Melissa C. Southey,Emad A. Rakha,Andrew R. Green,Ian O. Ellis,Mark E. Sherman,Jolanta Lissowska,William F. Anderson,Angela Cox,Simon S. Cross,Malcolm W.R. Reed,Elena Provenzano,Sarah-Jane Dawson,Alison M. Dunning,Manjeet K. Humphreys,Douglas F. Easton,Montserrat Garcia-Closas,Carlos Caldas,Paul D.P. Pharoah,David G. Huntsman +42 more
TL;DR: Paul Pharoah and colleagues evaluate the prognostic significance of immunohistochemical subtype classification in more than 10,000 breast cancer cases with early disease, and examines the influence of a patient's survival time on the prediction of future survival.
Journal ArticleDOI
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
Kyriaki Michailidou,Per Hall,Anna González-Neira,Maya Ghoussaini,Joe Dennis,Roger L. Milne,Marjanka K. Schmidt,Jenny Chang-Claude,Stig E. Bojesen,Manjeet K. Bolla,Qin Wang,Ed Dicks,Andy C. H. Lee,Clare Turnbull,Nazneen Rahman,Olivia Fletcher,Julian Peto,Lorna Gibson,Isabel dos Santos Silva,Heli Nevanlinna,Taru A. Muranen,Kristiina Aittomäki,Carl Blomqvist,Kamila Czene,Astrid K. Irwanto,Jianjun Liu,Quinten Waisfisz,Hanne Meijers-Heijboer,Muriel A. Adank,Rob B. van der Luijt,Rebecca Hein,N. Dahmen,Lars Beckman,Alfons Meindl,Rita K. Schmutzler,Bertram Müller-Myhsok,Peter Lichtner,John L. Hopper,Melissa C. Southey,Enes Makalic,Daniel F. Schmidt,Andre G. Uitterlinden,Albert Hofman,David J. Hunter,Stephen J. Chanock,Daniel Vincent,Francois Bacot,Daniel C. Tessier,Sander Canisius,Lodewyk F. A. Wessels,Christopher A. Haiman,Mitul Shah,Robert Luben,Judith E. Brown,Craig Luccarini,Nils Schoof,Keith Humphreys,Jingmei Li,Børge G. Nordestgaard,Sune F. Nielsen,Henrik Flyger,Fergus J. Couch,Xianshu Wang,Celine M. Vachon,Kristen N. Stevens,Diether Lambrechts,Matthieu Moisse,Robert Paridaens,Marie Rose Christiaens,Anja Rudolph,Stefan Nickels,Dieter Flesch-Janys,Dieter Flesch-Janys,Dieter Flesch-Janys,Nichola Johnson,Zoe Aitken,Kirsimari Aaltonen,Kirsimari Aaltonen,Tuomas Heikkinen,Annegien Broeks,Laura J. Van 'T Veer,C. Ellen van der Schoot,Pascal Guénel,Thérèse Truong,Pierre Laurent-Puig,Florence Menegaux,Frederik Marmé,Andreas Schneeweiss,Christof Sohn,Barbara Burwinkel,M. Pilar Zamora,Jose Ignacio Arias Perez,Guillermo Pita,M. Rosario Alonso,Angela Cox,Ian W. Brock,Simon S. Cross,Malcolm W.R. Reed,Elinor J. Sawyer,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Brian E. Henderson,Fredrick R. Schumacher,Loic Le Marchand,Irene L. Andrulis,Julia A. Knight,Gord Glendon,Anna Marie Mulligan,Annika Lindblom,Sara Margolin,Maartje J. Hooning,Antoinette Hollestelle,Ans M.W. van den Ouweland,Agnes Jager,Quang M. Bui,Jennifer Stone,Gillian S. Dite,Carmel Apicella,Helen Tsimiklis,Graham G. Giles,Gianluca Severi,Laura Baglietto,Peter A. Fasching,Lothar Haeberle,Arif B. Ekici,Matthias W. Beckmann,Hermann Brenner,Heiko Müller,Volker Arndt,Christa Stegmaier,Anthony J. Swerdlow,Alan Ashworth,Nick Orr,Michael Jones,Jonine D. Figueroa,Jolanta Lissowska,Louise A. Brinton,Mark S. Goldberg,Martine Dumont,Robert Winqvist,Katri Pylkäs,Arja Jukkola-Vuorinen,Mervi Grip,Hiltrud Brauch,Ute Hamann,Thomas Brüning,Paolo Radice,Paolo Peterlongo,Siranoush Manoukian,Bernardo Bonanni,Peter Devilee,Rob A. E. M. Tollenaar,Caroline M. Seynaeve,Christi J. van Asperen,Anna Jakubowska,Jan Lubinski,Katarzyna Jaworska,Katarzyna Durda,Arto Mannermaa,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Natalia Bogdanova,Natalia Antonenkova,Thilo Dörk,Vessela N. Kristensen,Hoda Anton-Culver,Susan L. Slager,Amanda E. Toland,Stephen Edge,Florentia Fostira,Daehee Kang,Keun-Young Yoo,Dong Young Noh,Keitaro Matsuo,Hidemi Ito,Hiroji Iwata,Aiko Sueta,Anna H. Wu,Chiu-Chen Tseng,David Van Den Berg,Daniel O. Stram,Xiao-Ou Shu,Wei Lu,Yu Tang Gao,Hui Cai,Soo Hwang Teo,Cheng Har Yip,Sze Yee Phuah,Belinda K. Cornes,Mikael Hartman,Hui Miao,Wei-Yen Lim,J. H. Sng,Kenneth Muir,Artitaya Lophatananon,Sarah Stewart-Brown,Pornthep Siriwanarangsan,Chen-Yang Shen,Chia-Ni Hsiung,Pei Ei Wu,Shian Ling Ding,Suleeporn Sangrajrang,Valerie Gaborieau,Paul Brennan,James McKay,William Blot,Lisa B. Signorello,Qiuyin Cai,Wei Zheng,Sandra Deming-Halverson,Martha J. Shrubsole,Jirong Long,Jacques Simard,M Garcia-Closas,Paul D.P. Pharoah,Georgia Chenevix-Trench,Alison M. Dunning,Javier Benitez,Douglas F. Easton +220 more
TL;DR: A meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, and identified 29,807 SNPs for further genotyping suggests that more than 1,000 additional loci are involved in breast cancer susceptibility.
Journal ArticleDOI
Association analysis identifies 65 new breast cancer risk loci
Kyriaki Michailidou,Kyriaki Michailidou,Sara Lindström,Sara Lindström,Joe Dennis,Jonathan Beesley,Shirley Hui,Siddhartha Kar,Audrey Lemaçon,Penny Soucy,Dylan M. Glubb,Asha Rostamianfar,Manjeet K. Bolla,Qin Wang,Jonathan Tyrer,Ed Dicks,Andy C. H. Lee,Zhaoming Wang,Jamie Allen,Renske Keeman,Ursula Eilber,Juliet D. French,Xiaoqing Chen,Laura Fachal,Karen McCue,Amy E. McCart Reed,Maya Ghoussaini,Jason S. Carroll,Xia Jiang,Hilary K. Finucane,Hilary K. Finucane,Marcia Adams,Muriel A. Adank,Habibul Ahsan,Kristiina Aittomäki,Hoda Anton-Culver,Natalia Antonenkova,Volker Arndt,Kristan J. Aronson,Banu Arun,Paul L. Auer,Paul L. Auer,Francois Bacot,Myrto Barrdahl,Caroline Baynes,Matthias W. Beckmann,Sabine Behrens,Javier Benitez,Marina Bermisheva,Leslie Bernstein,Carl Blomqvist,Natalia Bogdanova,Stig E. Bojesen,Stig E. Bojesen,Bernardo Bonanni,Anne Lise Børresen-Dale,Judith S. Brand,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Paul Brennan,Hermann Brenner,Louise A. Brinton,Per Broberg,Ian W. Brock,Annegien Broeks,Angela Brooks-Wilson,Angela Brooks-Wilson,Sara Y. Brucker,Thomas Brüning,Barbara Burwinkel,Barbara Burwinkel,Katja Butterbach,Qiuyin Cai,Hui Cai,Trinidad Caldés,Federico Canzian,Angel Carracedo,Brian D. Carter,Jose E. Castelao,Tsun Leung Chan,Tongguang Cheng,Kee Seng Chia,Ji Yeob Choi,Hans Christiansen,Christine L. Clarke,Margriet Collée,Don M. Conroy,Emilie Cordina-Duverger,Sten Cornelissen,David G. Cox,David G. Cox,Angela Cox,Simon S. Cross,Julie M. Cunningham,Kamila Czene,Mary B. Daly,Peter Devilee,Kimberly F. Doheny,Thilo Dörk,Isabel dos-Santos-Silva,Martine Dumont,Lorraine Durcan,Miriam Dwek,Diana Eccles,Arif B. Ekici,A. Heather Eliassen,A. Heather Eliassen,Carolina Ellberg,Mingajeva Elvira,Christoph Engel,Mikael Eriksson,Peter A. Fasching,Peter A. Fasching,Jonine D. Figueroa,Dieter Flesch-Janys,Olivia Fletcher,Henrik Flyger,Lin Fritschi,Valerie Gaborieau,Marike Gabrielson,Manuela Gago-Dominguez,Yu Tang Gao,Susan M. Gapstur,José A. García-Sáenz,Mia M. Gaudet,Vassilios Georgoulias,Graham G. Giles,Graham G. Giles,Gord Glendon,Mark S. Goldberg,David E. Goldgar,Anna González-Neira,Grethe I. Grenaker Alnæs,Mervi Grip,Jacek Gronwald,Anne Grundy,Pascal Guénel,Lothar Haeberle,Eric Hahnen,Christopher A. Haiman,Niclas Håkansson,Ute Hamann,N Hamel,Susan E. Hankinson,Patricia Harrington,Steven N. Hart,Jaana M. Hartikainen,Mikael Hartman,Mikael Hartman,Alexander Hein,Jane Heyworth,Belynda Hicks,Peter Hillemanns,Dona N. Ho,Antoinette Hollestelle,Maartje J. Hooning,Robert N. Hoover,John L. Hopper,Ming-Feng Hou,Chia-Ni Hsiung,Guanmengqian Huang,Keith Humphreys,Junko Ishiguro,Hidemi Ito,Motoki Iwasaki,Hiroji Iwata,Anna Jakubowska,Wolfgang Janni,Esther M. John,Esther M. John,Nichola Johnson,Kristine Jones,Michael Jones,Arja Jukkola-Vuorinen,Rudolf Kaaks,Maria Kabisch,Katarzyna Kaczmarek,Daehee Kang,Daehee Kang,Yoshio Kasuga,Michael J. Kerin,Sofia Khan,Elza Khusnutdinova,Elza Khusnutdinova,Johanna I. Kiiski,Sung-Won Kim,Julia A. Knight,Julia A. Knight,Veli-Matti Kosma,Vessela N. Kristensen,Vessela N. Kristensen,Ute Krüger,Ava Kwong,Diether Lambrechts,Loic Le Marchand,Eunjung Lee,Min Hyuk Lee,Jong Won Lee,Chuen Neng Lee,Flavio Lejbkowicz,Jingmei Li,Jenna Lilyquist,Annika Lindblom,Jolanta Lissowska,Wing-Yee Lo,Wing-Yee Lo,Sibylle Loibl,Jirong Long,Artitaya Lophatananon,Artitaya Lophatananon,Jan Lubinski,Craig Luccarini,Michael P. Lux,Edmond S. K. Ma,Robert J. MacInnis,Robert J. MacInnis,Tom Maishman,Enes Makalic,Kathleen E. Malone,Ivana Maleva Kostovska,Arto Mannermaa,Siranoush Manoukian,JoAnn E. Manson,JoAnn E. Manson,Sara Margolin,Shivaani Mariapun,Maria Elena Martinez,Keitaro Matsuo,Dimitrios Mavroudis,James McKay,Catriona McLean,Hanne Meijers-Heijboer,Alfons Meindl,Primitiva Menéndez,Usha Menon,J.-P. Meyer,Hui Miao,Nicola Miller,Nur Aishah Taib,Kenneth Muir,Kenneth Muir,Anna Marie Mulligan,Anna Marie Mulligan,Claire Mulot,Susan L. Neuhausen,Heli Nevanlinna,Patrick Neven,Sune F. Nielsen,Dong-Young Noh,Børge G. Nordestgaard,Børge G. Nordestgaard,Aaron D. Norman,Olufunmilayo I. Olopade,Janet E. Olson,Håkan Olsson,Curtis Olswold,Nick Orr,V. Shane Pankratz,Sue K. Park,Sue K. Park,Tjoung-Won Park-Simon,Rachel Lloyd,Jose Ignacio Arias Perez,Paolo Peterlongo,Julian Peto,Kelly-Anne Phillips,Mila Pinchev,Dijana Plaseska-Karanfilska,Ross L. Prentice,Nadege Presneau,Darya Prokofyeva,Elizabeth W. Pugh,Katri Pylkäs,Brigitte Rack,Paolo Radice,Nazneen Rahman,Gadi Rennert,Hedy S. Rennert,Valerie Rhenius,Atocha Romero,Jane Romm,Kathryn J. Ruddy,Thomas Rüdiger,Anja Rudolph,Matthias Ruebner,Emiel J. Th. Rutgers,Emmanouil Saloustros,Dale P. Sandler,Suleeporn Sangrajrang,Elinor J. Sawyer,Daniel F. Schmidt,Rita K. Schmutzler,Andreas Schneeweiss,Minouk J. Schoemaker,Fredrick R. Schumacher,Peter Schürmann,Rodney J. Scott,Rodney J. Scott,Christopher G. Scott,Sheila Seal,Caroline Seynaeve,Mitul Shah,Priyanka Sharma,Chen-Yang Shen,Chen-Yang Shen,Grace Sheng,Mark E. Sherman,Martha J. Shrubsole,Xiao-Ou Shu,Ann Smeets,Christof Sohn,Melissa C. Southey,John J. Spinelli,John J. Spinelli,Christa Stegmaier,Sarah Stewart-Brown,Jennifer Stone,Jennifer Stone,Daniel O. Stram,Harald Surowy,Harald Surowy,Anthony J. Swerdlow,Rulla M. Tamimi,Rulla M. Tamimi,Jack A. Taylor,Maria Tengström,Soo Hwang Teo,Mary Beth Terry,Daniel C. Tessier,Somchai Thanasitthichai,Kathrin Thöne,Rob A. E. M. Tollenaar,Ian Tomlinson,Ling Tong,Diana Torres,Diana Torres,Thérèse Truong,Chiu-Chen Tseng,Shoichiro Tsugane,Hans-Ulrich Ulmer,Giske Ursin,Michael Untch,Celine M. Vachon,Christi J. van Asperen,David Van Den Berg,Ans M.W. van den Ouweland,Lizet E. van der Kolk,Rob B. van der Luijt,Daniel Vincent,Jason Vollenweider,Quinten Waisfisz,Shan Wang-Gohrke,Clarice R. Weinberg,Camilla Wendt,Alice S. Whittemore,Hans Wildiers,Walter C. Willett,Robert Winqvist,Alicja Wolk,Anna H. Wu,Lucy Xia,Taiki Yamaji,Xiaohong R. Yang,Cheng Har Yip,Keun-Young Yoo,Jyh-Cherng Yu,Wei Zheng,Ying Zheng,Bin Zhu,Argyrios Ziogas,Elad Ziv,Sunil R. Lakhani,Sunil R. Lakhani,Antonis C. Antoniou,Arnaud Droit,Irene L. Andrulis,Irene L. Andrulis,Christopher I. Amos,Fergus J. Couch,Paul D.P. Pharoah,Jenny Chang-Claude,Jenny Chang-Claude,Per Hall,David J. Hunter,Roger L. Milne,Roger L. Milne,Montserrat Garcia-Closas,Marjanka K. Schmidt,Stephen J. Chanock,Alison M. Dunning,Stacey L. Edwards,Gary D. Bader,Georgia Chenevix-Trench,Jacques Simard,Peter Kraft,Douglas F. Easton +396 more
TL;DR: A genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry finds that heritability of Breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2–5-fold enriched relative to the genome- wide average.
Journal ArticleDOI
RAD51B in Familial Breast Cancer
Liisa M. Pelttari,Sofia Khan,Mikko Vuorela,Johanna I. Kiiski,Sara Vilske,Viivi Nevanlinna,Salla Ranta,Johanna Schleutker,Johanna Schleutker,Johanna Schleutker,Robert Winqvist,Anne Kallioniemi,Thilo Dörk,Natalia Bogdanova,Jonine Figueroa,Paul D.P. Pharoah,Marjanka K. Schmidt,Alison M. Dunning,Montserrat Garcia-Closas,Manjeet K. Bolla,Joe Dennis,Kyriaki Michailidou,Qin Wang,John L. Hopper,Melissa C. Southey,Efraim H. Rosenberg,Peter A. Fasching,Peter A. Fasching,Matthias W. Beckmann,Julian Peto,Isabel dos-Santos-Silva,Elinor J. Sawyer,Ian Tomlinson,Barbara Burwinkel,Barbara Burwinkel,Harald Surowy,Harald Surowy,Pascal Guénel,Thérèse Truong,Stig E. Bojesen,Stig E. Bojesen,Børge G. Nordestgaard,Børge G. Nordestgaard,Javier Benitez,Anna González-Neira,Susan L. Neuhausen,Hoda Anton-Culver,Hermann Brenner,Volker Arndt,Alfons Meindl,Rita K. Schmutzler,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Thomas Brüning,Annika Lindblom,Sara Margolin,Arto Mannermaa,Jaana M. Hartikainen,Georgia Chenevix-Trench,kConFab,kConFab,Aocs Investigators,Laurien Van Dyck,Hilde Janssen,Hilde Janssen,Jenny Chang-Claude,Anja Rudolph,Paolo Radice,Paolo Peterlongo,Emily Hallberg,Janet E. Olson,Janet E. Olson,Graham G. Giles,Graham G. Giles,Roger L. Milne,Christopher A. Haiman,Fredrick Schumacher,Jacques Simard,Martine Dumont,Martine Dumont,Vessela N. Kristensen,Vessela N. Kristensen,Anne Lise Børresen-Dale,Wei Zheng,Alicia Beeghly-Fadiel,Mervi Grip,Mervi Grip,Irene L. Andrulis,Gord Glendon,Peter Devilee,Caroline Seynaeve,Maartje J. Hooning,Margriet Collée,Angela Cox,Simon S. Cross,Mitul Shah,Robert Luben,Ute Hamann,Ute Hamann,Diana Torres,Anna Jakubowska,Jan Lubinski,Fergus J. Couch,Drakoulis Yannoukakos,Nick Orr,Anthony J. Swerdlow,Hatef Darabi,Jingmei Li,Kamila Czene,Per Hall,Douglas F. Easton,Johanna Mattson,Carl Blomqvist,Kristiina Aittomäki,Heli Nevanlinna +115 more
TL;DR: It is suggested that loss-of-function mutations in RAD 51B are rare, but common variation at the RAD51B region is significantly associated with familial breast cancer risk.