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Alison R. Moliterno
Researcher at Johns Hopkins University School of Medicine
Publications - 140
Citations - 3626
Alison R. Moliterno is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Polycythemia vera & Myelofibrosis. The author has an hindex of 30, co-authored 129 publications receiving 3143 citations. Previous affiliations of Alison R. Moliterno include Johns Hopkins University.
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Journal ArticleDOI
Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders
Zhaohui Ye,Huichun Zhan,Prashant Mali,Prashant Mali,Sarah N. Dowey,Donna M. Williams,Yoon Young Jang,Chi V. Dang,Jerry L. Spivak,Alison R. Moliterno,Linzhao Cheng,Linzhao Cheng +11 more
TL;DR: In this article, the authors derived human induced pluripotent stem (iPS) cells from postnatal human blood cells and the potential of these pluripotency cells for disease modeling.
Journal ArticleDOI
Impaired expression of the thrombopoietin receptor by platelets from patients with polycythemia vera.
TL;DR: Impaired thrombopoietin-induced tyrosine phosphorylation of proteins in patients with these two diseases was uniformly associated with markedly reduced expression of MpI or the lack of its expression, and appears to distinguish polycythemia vera from other-forms of erythrocytosis.
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Platelet counts differ by sex, ethnicity, and age in the United States.
Jodi B Segal,Alison R. Moliterno +1 more
TL;DR: Platelet count differences by sex, ethnicity, and age are not explained by environmental covariates known to influence platelet count.
Journal ArticleDOI
Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies.
Hideki Makishima,Anna M. Jankowska,Ramon V. Tiu,Hadrian Szpurka,Yuka Sugimoto,Zhenbo Hu,Yogen Saunthararajah,Kathryn M Guinta,Mehdi Keddache,P Putnam,Mikkael A. Sekeres,Alison R. Moliterno,Alan F. List,Michael A. McDevitt,Jaroslaw P. Maciejewski +14 more
TL;DR: It can be postulated that areas of somatic UPD may identify regions that harbor mutations in the regions affected by the copy number neutral loss of heterozygosity/UPD.
Journal ArticleDOI
Multiple mechanisms deregulate EZH2 and histone H3 lysine 27 epigenetic changes in myeloid malignancies
Shahper N. Khan,Anna M. Jankowska,Reda Z. Mahfouz,Andrew Dunbar,Yuka Sugimoto,Naoko Hosono,Zhenbo Hu,Venugopalan Cheriyath,Sergei Vatolin,Bartlomiej P Przychodzen,Frederic J. Reu,Yogen Saunthararajah,Christine L. O'Keefe,Mikkael A. Sekeres,Alan F. List,Alison R. Moliterno,Michael A. McDevitt,Jaroslaw P. Maciejewski,Hideki Makishima +18 more
TL;DR: The results suggest that loss of gene repression through a variety of mutations resulting in reduced H3K27 trimethylation may contribute to leukemogenesis.