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Alistair J. P. Brown
Researcher at University of Exeter
Publications - 281
Citations - 23559
Alistair J. P. Brown is an academic researcher from University of Exeter. The author has contributed to research in topics: Candida albicans & Corpus albicans. The author has an hindex of 77, co-authored 269 publications receiving 21472 citations. Previous affiliations of Alistair J. P. Brown include Marischal College & University of Otago.
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Journal ArticleDOI
Antifungal agents: mechanisms of action
TL;DR: The sordarins represent a novel class of agents that inhibit fungal protein synthesis, and three are echinocandins, which inhibit synthesis of fungal cell wall polysaccharides--a new mode of action.
Journal ArticleDOI
Evolution of pathogenicity and sexual reproduction in eight Candida genomes.
Geraldine Butler,Matthew D. Rasmussen,Michael F. Lin,Michael F. Lin,Manuel A. S. Santos,Sharadha Sakthikumar,Carol A. Munro,Esther Rheinbay,Esther Rheinbay,Manfred Grabherr,Anja Forche,Jennifer L. Reedy,Ino Agrafioti,Martha B. Arnaud,Steven Bates,Alistair J. P. Brown,Sascha Brunke,Maria C. Costanzo,David A. Fitzpatrick,Piet W. J. de Groot,David Harris,Lois L. Hoyer,Bernhard Hube,Frans M. Klis,Chinnappa D. Kodira,Nicola Lennard,Mary E. Logue,Ronny Martin,Aaron M. Neiman,Elissavet Nikolaou,Michael A. Quail,Janet Quinn,Maria C. Santos,Florian F. Schmitzberger,Gavin Sherlock,Prachi Shah,Kevin A. T. Silverstein,Marek S. Skrzypek,David R. Soll,Rodney Staggs,Ian Stansfield,Michael P. H. Stumpf,Peter E. Sudbery,Thyagarajan Srikantha,Qiandong Zeng,Judith Berman,Matthew Berriman,Joseph Heitman,Neil A. R. Gow,Michael C. Lorenz,Bruce W. Birren,Manolis Kellis,Manolis Kellis,Christina A. Cuomo +53 more
TL;DR: There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence in Candida albicans species.
Journal ArticleDOI
The complete DNA sequence of yeast chromosome III.
Stephen G. Oliver,Q. J. M. van der Aart,M. L. Agostoni-Carbone,Michel Aigle,Lilia Alberghina,Despina Alexandraki,G. Antoine,Rashida Anwar,Juan P. G. Ballesta,Paule Bénit,Gilbert Berben,Elisabetta Bergantino,N. Biteau,P. A. Bolle,Monique Bolotin-Fukuhara,Anthony G. A. Brown,Alistair J. P. Brown,J. M. Buhler,C. Carcano,Giovanna Carignani,Håkan Cederberg,R. Chanet,Roland Contreras,Marc Crouzet,B. Daignan-Fornier,E. Defoor,M. Delgado,Jan Demolder,C. Doira,Evelyne Dubois,Bernard Dujon,A. Düsterhöft,D. Erdmann,M. Esteban,F. Fabre,Cécile Fairhead,Gérard Faye,Horst Feldmann,Walter Fiers,M. C. Francingues-Gaillard,L. Franco,Laura Frontali,H. Fukuhara,L. J. Fuller,P. Galland,Manda E. Gent,D. Gigot,Véronique Gilliquet,Glansdorff Nn,André Goffeau,M. Grenson,P. Grisanti,Leslie A. Grivell,M. de Haan,M. Haasemann,D. Hatat,Janet Hoenicka,Johannes H. Hegemann,C. J. Herbert,François Hilger,Stefan Hohmann,Cornelis P. Hollenberg,K. Huse,F. Iborra,K. J. Indje,K. Isono,C. Jacq,M. Jacquet,C. M. James,J. C. Jauniaux,Y. Jia,Alberto Jiménez,A. Kelly,U. Kleinhans,P Kreisl,G. Lanfranchi,C Lewis,C. G. vanderLinden,G Lucchini,K Lutzenkirchen,M.J. Maat,L. Mallet,G. Mannhaupet,Enzo Martegani,A. Mathieu,C. T. C. Maurer,David J. McConnell,R. A. McKee,F. Messenguy,Hans-Werner Mewes,Francis Molemans,M. A. Montague,M. Muzi Falconi,L. Navas,Carol S. Newlon,D. Noone,C. Pallier,L. Panzeri,Bruce M. Pearson,J. Perea,Peter Philippsen,A. Pierard,Rudi J. Planta,Paolo Plevani,B. Poetsch,Fritz M. Pohl,B. Purnelle,M. Ramezani Rad,S. W. Rasmussen,A. Raynal,Miguel Remacha,P. Richterich,Aki Roberts,F. Rodriguez,E. Sanz,I. Schaaff-Gerstenschlager,Bart Scherens,Bertold Schweitzer,Y. Shu,J. Skala,Piotr P. Slonimski,F. Sor,C. Soustelle,R. Spiegelberg,Lubomira Stateva,H. Y. Steensma,S. Steiner,Agnès Thierry,George Thireos,Maria Tzermia,L. A. Urrestarazu,Giorgio Valle,I. Vetter,J. C. van Vliet-Reedijk,Marleen Voet,Guido Volckaert,P. Vreken,H. Wang,John R. Warmington,D. von Wettstein,Barton Luke Wicksteed,C. Wilson,H. Wurst,G. Xu,A. Yoshikawa,Friedrich K. Zimmermann,J. G. Sgouros +146 more
TL;DR: The entire DNA sequence of chromosome III of the yeast Saccharomyces cerevisiae has been determined, which is the first complete sequence analysis of an entire chromosome from any organism.
Journal ArticleDOI
Candida albicans morphogenesis and host defence: discriminating invasion from colonization
TL;DR: The properties of yeast cells and hyphae that are relevant to their interaction with the host, and the immunological mechanisms that differentially recognize colonizing versus invading C. albicans are described.
Journal ArticleDOI
Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors
Mihai G. Netea,Neil A. R. Gow,Carol A. Munro,Steven Bates,Claire Collins,Gerben Ferwerda,Richard P. Hobson,Gwyneth Bertram,H. Bleddyn Hughes,Trees Jansen,Liesbeth Jacobs,Ed T. Buurman,Karlijn Gijzen,David L. Williams,Ruurd Torensma,Alistair McKinnon,Donna M. MacCallum,Frank C. Odds,Jos W. M. van der Meer,Alistair J. P. Brown,Bart Jan Kullberg +20 more
TL;DR: It is demonstrated that cytokine production by human mononuclear cells or murine macrophages was markedly reduced when stimulated by C. albicans mutants defective in mannosylation and recognition of C.Albicans by monocytes/macrophages is mediated by 3 recognition systems of differing importance, each of which senses specific layers of the C. Albicans cell wall.