Alistair Mathie

TL;DR: The Fifth Edition of the 'Guide to Receptors and Channels' is a compilation of the major pharmacological targets divided into seven sections: G protein-coupled receptors, ligand-gated ion channels, ion channel, catalytic receptors, nuclear receptors, transporters and enzymes.

TL;DR: The Concise Guide to PHARMACOLOGY 2019/20 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology, plus links to the open access knowledgebase source of drug targets and their ligands ( www.guidetopharmacology.org).

TL;DR: Enzymes are one of the six major pharmacological targets into which the Concise Guide is divided, with the others being: G protein‐coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors and transporters.

TL;DR: It is shown that certain members of the two-pore-domain K+ channel superfamily may represent an important new target for these gaseous anesthetics and that Glu306, an amino acid that has previously been found to be important in the modulation of TREK-1 by arachidonic acid, membrane stretch and internal pH, is critical for the activating effects of the anesthetic gases.

TL;DR: The Concise Guide to PHARMACOLOGY 2019/20 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands ( www.guidetopharmacology.org).