Allan S. Hoffman

Bio: Allan S. Hoffman is an academic researcher from University of Washington. The author has contributed to research in topics: Self-healing hydrogels & Lower critical solution temperature. The author has an hindex of 90, co-authored 355 publications receiving 37702 citations. Previous affiliations of Allan S. Hoffman include Kyungpook National University & Shanghai University.

Biomaterials Science: An Introduction to Materials in Medicine

Abstract: B.D. Ratner, Biomaterials Science: An Interdisciplinary Endeavor. Materials Science and Engineering--Properties of Materials: J.E. Lemons, Introduction. F.W. Cooke, Bulk Properties of Materials. B.D. Ratner, Surface Properties of Materials. Classes of Materials Used in Medicine: A.S. Hoffman, Introduction. J.B. Brunski, Metals. S.A. Visser, R.W. Hergenrother, and S.L. Cooper, Polymers. N.A. Peppas, Hydrogels. J. Kohnand R. Langer, Bioresorbable and Bioerodible Materials. L.L. Hench, Ceramics, Glasses, and Glass Ceramics. I.V. Yannas, Natural Materials. H. Alexander, Composites. B.D. Ratner and A.S. Hoffman, Thin Films, Grafts, and Coatings. S.W. Shalaby, Fabrics. A.S. Hoffman, Biologically Functional Materials. Biology, Biochemistry, and Medicine--Some Background Concepts: B.D. Ratner, Introduction. T.A. Horbett, Proteins: Structure, Properties, and Adsorption to Surfaces. J.M. Schakenraad, Cells: Their Surfaces and Interactions with Materials. F.J. Schoen, Tissues. Host Reactions to Biomaterials and Their Evaluations: F.J. Schoen, Introduction. J.M. Anderson, Inflammation, Wound Healing, and the Foreign Body Response. R.J. Johnson, Immunology and the Complement System. K. Merritt, Systemic Toxicity and Hypersensitivity. S.R. Hanson and L.A. Harker, Blood Coagulation and Blood-Materials Interaction. F.J.Schoen, Tumorigenesis and Biomaterials. A.G. Gristina and P.T. Naylor, Implant-Associated Infection. Testing Biomaterials: B.D. Ratner, Introduction. S.J. Northup, In Vitro Assessment of Tissue Compatibility. M. Spector and P.A. Lalor, In Vivo Assessment of Tissue Compatibility. S. Hanson and B.D. Ratner, Testing of Blood-Material Interactions. B.H. Vale, J.E. Willson, and S.M. Niemi, Animal Models. Degradation of Materials in the Biological Environment: B.D. Ratner, Introduction. A.J. Coury, Chemical and Biochemical Degradation of Polymers. D.F. Williams and R.L. Williams, Degradative Effects of the Biological Environment on Metals and Ceramics. C.R. McMillin, Mechanical Breakdown in the Biological Environment. Y. Pathak, F.J. Schoen, and R.J. Levy, Pathologic Calcification of Biomaterials. Application of Materials in Medicine and Dentistry: J.E. Lemons, Introduction. D. Didisheim and J.T. Watson, Cardiovascular Applications. S.W. Kim, Nonthrombogenic Treatments and Strategies. J.E. Lemons, Dental Implants. D.C. Smith, Adhesives and Sealants. M.F. Refojo, Ophthalmologic Applications. J.L. Katz, Orthopedic Applications. J. Heller, Drug Delivery Systems. D. Goupil, Sutures. J.B. Kane, R.G. Tompkins, M.L. Yarmush, and J.F. Burke, Burn Dressings. L.S. Robblee and J.D. Sweeney, Bioelectrodes. P. Yager, Biomedical Sensors and Biosensors. Artificial Organs: F.J. Schoen, Introduction. K.D. Murray and D.B. Olsen, Implantable Pneumatic Artificial Hearts. P. Malchesky, Extracorporeal Artificial Organs. Practical Aspects of Biomaterials--Implants and Devices: F.J. Schoen, Introduction. J.B. Kowalski and R.F. Morrissey, Sterilization of Implants. L.M. Graham, D. Whittlesey, and B. Bevacqua, Cardiovascular Implantation. A.N. Cranin, M. Klein, and A. Sirakian, Dental Implantation. S.A. Obstbaum, Ophthalmic Implantation. A.E. Hoffman, Implant and Device Failure. B.D. Ratner, Correlations of Material Surface Properties with Biological Responses. J.M. Anderson, Implant Retrieval and Evaluation. New Products and Standards: J.E. Lemons, Introduction. S.A. Brown, Voluntary Consensus Standards. N.B. Mateo, Product Development and Regulation. B. Ratner, Perspectives and Possibilities in Biomaterials Science. Appendix: S. Slack, Properties of Biological Fluids. Subject Index.

Design and development of polymers for gene delivery

Abstract: The lack of safe and efficient gene-delivery methods is a limiting obstacle to human gene therapy. Synthetic gene-delivery agents, although safer than recombinant viruses, generally do not possess the required efficacy. In recent years, a variety of effective polymers have been designed specifically for gene delivery, and much has been learned about their structure–function relationships. With the growing understanding of polymer gene-delivery mechanisms and continued efforts of creative polymer chemists, it is likely that polymer-based gene-delivery systems will become an important tool for human gene therapy.

Hydrogels for Biomedical Applications

Abstract: This paper reviews the composition and synthesis of hydrogels, the character of their absorbed water, and permeation of solutes within their swollen matrices The most important properties of hydrogels relevant to their biomedical applications are also identified, in particular for use of hydrogels as drug and cell carriers, and as tissue engineering matrices

Graft copolymers that exhibit temperature-induced phase transitions over a wide range of pH

Abstract: There are many potential applications of 'intelligent' aqueous polymer systems in medicine, biotechnology, industry and in environmental problems. Many of these polymer systems undergo reversible phase transitions--for example, abrupt changes in volume--in response to external stimuli such as temperature, pH or the nature of the solvent. Most of the polymers studied previously are responsive to only one kind of stimulus. But for some applications, independent responsiveness to several factors, such as temperature and pH, may be required. Here we describe a polymer that undergoes marked solubility changes in water in response to temperature and/or pH changes. The polymer is prepared by grafting temperature-sensitive side chains onto a pH-sensitive backbone. We also find that block copolymers, in which the temperature- and pH-sensitive units alternate along the chain, show similar behaviour.

I and i

Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

Mussel-Inspired Surface Chemistry for Multifunctional Coatings

Abstract: We report a method to form multifunctional polymer coatings through simple dip-coating of objects in an aqueous solution of dopamine. Inspired by the composition of adhesive proteins in mussels, we used dopamine self-polymerization to form thin, surface-adherent polydopamine films onto a wide range of inorganic and organic materials, including noble metals, oxides, polymers, semiconductors, and ceramics. Secondary reactions can be used to create a variety of ad-layers, including self-assembled monolayers through deposition of long-chain molecular building blocks, metal films by electroless metallization, and bioinert and bioactive surfaces via grafting of macromolecules.

A review of chitin and chitosan applications

Abstract: Chitin is the most abundant natural amino polysaccharide and is estimated to be produced annually almost as much as cellulose. It has become of great interest not only as an underutilized resource, but also as a new functional material of high potential in various fields, and recent progress in chitin chemistry is quite noteworthy. The purpose of this review is to take a closer look at chitin and chitosan applications. Based on current research and existing products, some new and futuristic approaches in this fascinating area are thoroughly discussed.