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Alois Haromy
Researcher at University of Alberta
Publications - 39
Citations - 7832
Alois Haromy is an academic researcher from University of Alberta. The author has contributed to research in topics: Pulmonary hypertension & Apoptosis. The author has an hindex of 26, co-authored 32 publications receiving 7112 citations.
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Journal ArticleDOI
A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth
Sébastien Bonnet,Stephen L. Archer,Joan Allalunis-Turner,Alois Haromy,Christian Beaulieu,Richard B. Thompson,Christopher T. Lee,Gary D. Lopaschuk,Lakshmi Puttagunta,Sandra Bonnet,Gwyneth Harry,Kyoko Hashimoto,Christopher J. Porter,Miguel A. Andrade,Bernard Thébaud,Evangelos D. Michelakis +15 more
TL;DR: The unique metabolic profile of cancer (aerobic glycolysis) might confer apoptosis resistance and be therapeutically targeted and the orally available DCA is a promising selective anticancer agent.
Journal ArticleDOI
Metabolic Modulation of Glioblastoma with Dichloroacetate
Evangelos D. Michelakis,Gopinath Sutendra,Peter Dromparis,Linda Webster,Alois Haromy,E. Niven,C. Maguire,John R. Mackey,Dorcas Fulton,Bassam Abdulkarim,Michael Sean McMurtry,K. C. Petruk +11 more
TL;DR: Dichloroacetate appears to be safe to give to humans at doses that are required for pyruvate dehydrogenase inhibition, and can be added to a growing group of metabolic modulators that may prove useful in cancer therapy.
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An Abnormal Mitochondrial–Hypoxia Inducible Factor-1α–Kv Channel Pathway Disrupts Oxygen Sensing and Triggers Pulmonary Arterial Hypertension in Fawn Hooded Rats Similarities to Human Pulmonary Arterial Hypertension
Sébastien Bonnet,Evangelos D. Michelakis,Christopher J. Porter,Miguel A. Andrade-Navarro,Bernard Thébaud,Sandra Bonnet,Alois Haromy,Gwyneth Harry,Rohit Moudgil,M. Sean McMurtry,E. Kenneth Weir,Stephen L. Archer +11 more
TL;DR: An intersection between oxygen-sensing mechanisms and PAH is revealed, analogous to the pathophysiology of chronically hypoxic Sprague-Dawley rats, and the mitochondria-ROS-HIF-Kv pathway offers new targets for PAH therapy.
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Phosphodiesterase Type 5 Is Highly Expressed in the Hypertrophied Human Right Ventricle, and Acute Inhibition of Phosphodiesterase Type 5 Improves Contractility
Jayan Nagendran,Stephen L. Archer,Daniel Soliman,Vikram Gurtu,Rohit Moudgil,Alois Haromy,Chantal St. Aubin,Linda Webster,Ivan M. Rebeyka,David B. Ross,Peter E. Light,Jason R.B. Dyck,Evangelos D. Michelakis +12 more
TL;DR: The ability of PDE5 inhibitors to increase RV inotropy and to decrease RV afterload without significantly affecting systemic hemodynamics makes them ideal for the treatment of diseases affecting the RV, including pulmonary arterial hypertension.
Journal ArticleDOI
Vascular Endothelial Growth Factor Gene Therapy Increases Survival, Promotes Lung Angiogenesis, and Prevents Alveolar Damage in Hyperoxia-Induced Lung Injury Evidence That Angiogenesis Participates in Alveolarization
Bernard Thébaud,Faruqa Ladha,Evangelos D. Michelakis,Monika Sawicka,Gavin Thurston,Farah Eaton,Kyoko Hashimoto,Gwyneth Harry,Alois Haromy,Greg Korbutt,Stephen L. Archer +10 more
TL;DR: These findings underscore the importance of the vasculature in what is traditionally thought of as an airway disease and open new therapeutic avenues for lung diseases characterized by irreversible loss of alveoli through the modulation of angiogenic growth factors.